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Atypical Femoral Fracture Combined with Osteonecrosis of Jaw During Osteoporosis Treatment with Bisphosphonate

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초록

Bisphosphonate, a potent anti-resorptive agent, is generally accepted as a safe, effective,well tolerated treatment for postmenopausal osteoporosis. Atypical femoral fracture(AFF) and bisphosphonate related osteonecrosis of jaw (BRONJ) are the increasing mor-bidities in patients treated with long term bisphosphonate. Pathogenic mechanisms ofAFF and BRONJ are not fully identified and not identical. We report a case of BRONJ fol-lowed by AFF and its nonunion in a 67-year-old woman patient receiving an oralbisphosphonate during 7 years for the treatment of osteoporosis.

Abstract

Bisphosphonate, a potent anti-resorptive agent, is generally accepted as a safe, effective,well tolerated treatment for postmenopausal osteoporosis. Atypical femoral fracture(AFF) and bisphosphonate related osteonecrosis of jaw (BRONJ) are the increasing mor-bidities in patients treated with long term bisphosphonate. Pathogenic mechanisms ofAFF and BRONJ are not fully identified and not identical. We report a case of BRONJ fol-lowed by AFF and its nonunion in a 67-year-old woman patient receiving an oralbisphosphonate during 7 years for the treatment of osteoporosis.

참고문헌 (19)

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