자초의 천연색을 이용한 립밤에 관한 연구
A Study on Lip-Balm Usability from Lithospermum erthrohizon
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Lip balm is now one of useful cosmetics and the phenomena of well-being and LOHAS have extended to the area of cosmetics of which quality is assured. In this study, usability of Lithospermum erthrohizon (L. erthrohizon) investigated to natural cosmetic materials. Ethyl alcohol extract from L. erthrohizon was observed cytotoxicity, DPPH scavenging effect and antimicrobial activity. And lip balm made of 10% L. erthrohizon extract from ethyl alcohol and jojoba oil extract, and tested safety, usability and stability. In the result, fifty percent of fibroblast viability and brain cells were shown at the concentration of 128 mg/mL and 106 mg/mL of ethyl alcohol extracts. No extraordinary reaction or phenomena were detected like erythema (-) or allergy (-) when fore arms were patched for 48 hours with 10% lip balm made of ethyl alcohol and oil extracts. With regard to stability, there was little change in color but generation of alien substances and acidification from UV irradiation to 10% lip balm. Extremely positive responses were directed to lip balm in the order of color, feeling after application, applicability, fragrance and color reaction. DPPH scavenging activity was observed at the concentration of 5.0 mg/mL of ethyl alcohol extracts in comparison with the concentration 0.1 mg/mL of BHT as positive control material. Fractions of ethyl acetate and butanol from L. erthrohizon were measured at 12.5 mg/mL same scavenging effect as BHT. And antimicrobial activities revealed formation of clear zone with size of 9.5 mm against to S. aureus and 10 mm clear zone against to S. epidermidis at the concentration of 100 mg/mL. In conclusion, L. erthrohizon turned out to have excellent effects and antimicrobial activities as natural substance. And the lip balm made of L. erthrohizon is expected to suffice the 4 major requirements of cosmetics (safety, stability, effectiveness and usability), it is thought to be usefully employed in developing the products with natural substances that are verified of antioxidant effect and antimicrobial activity in the industry of cosmetics.
Abstract
Lip balm is now one of useful cosmetics and the phenomena of well-being and LOHAS have extended to the area of cosmetics of which quality is assured. In this study, usability of Lithospermum erthrohizon (L. erthrohizon) investigated to natural cosmetic materials. Ethyl alcohol extract from L. erthrohizon was observed cytotoxicity, DPPH scavenging effect and antimicrobial activity. And lip balm made of 10% L. erthrohizon extract from ethyl alcohol and jojoba oil extract, and tested safety, usability and stability. In the result, fifty percent of fibroblast viability and brain cells were shown at the concentration of 128 mg/mL and 106 mg/mL of ethyl alcohol extracts. No extraordinary reaction or phenomena were detected like erythema (-) or allergy (-) when fore arms were patched for 48 hours with 10% lip balm made of ethyl alcohol and oil extracts. With regard to stability, there was little change in color but generation of alien substances and acidification from UV irradiation to 10% lip balm. Extremely positive responses were directed to lip balm in the order of color, feeling after application, applicability, fragrance and color reaction. DPPH scavenging activity was observed at the concentration of 5.0 mg/mL of ethyl alcohol extracts in comparison with the concentration 0.1 mg/mL of BHT as positive control material. Fractions of ethyl acetate and butanol from L. erthrohizon were measured at 12.5 mg/mL same scavenging effect as BHT. And antimicrobial activities revealed formation of clear zone with size of 9.5 mm against to S. aureus and 10 mm clear zone against to S. epidermidis at the concentration of 100 mg/mL. In conclusion, L. erthrohizon turned out to have excellent effects and antimicrobial activities as natural substance. And the lip balm made of L. erthrohizon is expected to suffice the 4 major requirements of cosmetics (safety, stability, effectiveness and usability), it is thought to be usefully employed in developing the products with natural substances that are verified of antioxidant effect and antimicrobial activity in the industry of cosmetics.
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