Bisphosphonate-related osteonecrosis of the jaw in patients received long term treatment of oral bisphosphonate administration: Case reports
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Bisphosphonate-related osteonecrosis of the jaw (BRONJ) has been increasing every year, as the number of elders receiving bisphosphonate (BPs) therapy is increases. It is believed that BPs enhance the ORN by inhibition of the osteoclastic activity, but the exact mechanism is poorly understood. Patients who had received long-term oral BP therapy had a high recurrence rate of BRONJ. They needed to undergo segmental mandibulectomy and reconstruction, beyond getting just the conservative treatment, such as sequestrectomy. We present 2 such cases in this report. The patients had 7 years and 13 years of oral BP administration, respectively. These cases are being reported as we had good results after reconstruction, using reconstruction plate subsequent to segmental mandibulectomy.
Abstract
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) has been increasing every year, as the number of elders receiving bisphosphonate (BPs) therapy is increases. It is believed that BPs enhance the ORN by inhibition of the osteoclastic activity, but the exact mechanism is poorly understood. Patients who had received long-term oral BP therapy had a high recurrence rate of BRONJ. They needed to undergo segmental mandibulectomy and reconstruction, beyond getting just the conservative treatment, such as sequestrectomy. We present 2 such cases in this report. The patients had 7 years and 13 years of oral BP administration, respectively. These cases are being reported as we had good results after reconstruction, using reconstruction plate subsequent to segmental mandibulectomy.
참고문헌 (17)
- Sigua-Rodriguez EA, "Bisphosphonate-Related Osteonecrosis of the Jaw : A Review of the Literature", Int J Dent, 2014, pp.192320~ (2014)
- Vescovi P, "Conservative surgical management of stage I bisphosphonate-related osteonecrosis of the jaw", Int J Dent, 2014, pp.107690~ (2014)
- Yoshiga D, "Prognosis factors in the treatment of bisphosphonate-related osteonecrosis of the jaw - Prognostic factors in the treatment of BRONJ", J Clin Exp Dent, 6, pp.e22~e28 (2014)
- Lemound J, "Bisphosphonate-associated osteonecrosis of the mandible : reliable soft tissue reconstruction using a local myofascial flap", Clin Oral Investig, 16, pp.1143~1152 (2012)
- Kumar V, "Nitrogen containing bisphosphonates associated osteonecrosis of the jaws : A review for past 10 year literature", Dent Res J(Isfahan), 11, pp.147~153 (2014)
- Khosla S, "Oral bisphosphonate-induced osteonecrosis : risk factors, prediction of risk using serum CTX testing, prevention, and treatment", J Oral Maxillofac Surg, 66, pp.1320~1321 (2008)
- Woo SB, "Systematic Review : Bisphosphonates and Osteonecrosis of the Jaws", Ann Intern Med, 144, pp.753~761 (2006)
- Hoefert S, "Atraumatic tooth extraction in patients taking bisphosphonates : a review of literature and experience with three cases", Oral Maxillofac Surg, 18, pp.341~349 (2014)
- Wutzl A, "Factors influencing surgical treatment of bisphosphonate-related osteonecrosis of the jaws", Head Neck, 34, pp.194~200 (2012)
- Lee LW, "Clinical treatment outcomes for 40 patients with bisphosphonates-related osteonecrosis of the jaws", J Formos Med Assoc, 113, pp.166~172 (2014)
- Hewson I, "Radical surgical treatment of bisphosphonate related osteonecrosis of the jaw", Aust Dent J, 57, pp.227~230 (2012)
- Landesberg R, "Inhibition of oral mucosal cell wound healing by bisphosphonates", J Oral Maxillofac Surg, 66, pp.839~847 (2008)
- Altay MA, "Low-level laser therapy supported surgical treatment of bisphosphonate related osteonecrosis of jaws : a retrospective analysis of 11 cases", Photomed Laser Surg, 32, pp.468~475 (2014)
- Wongchuensoontorn C, "Pathological fractures in patients caused by bisphosphonate-related osteonecrosis of the jaws : report of 3 cases", J Oral Maxillofac Surg, 67, pp.1311~1316 (2009)
- Hanasono MM, "Mandibulectomy and free flap reconstruction for bisphosphonate-related osteonecrosis of the jaws", JAMA Otolaryngol Head Neck Surg, 139, pp.1135~1142 (2013)
- Gallego L, "The use of pedicled buccal fat pad combined with sequestrectomy in bisphosphonate-related osteonecrosis of the maxilla", Med Oral Patol Oral Cir Bucal, 17, pp.e236~e241 (2012)
- Sarkarat F, "Platelet-Rich Plasma in Treatment of Zoledronic Acid-Induced Bisphosphonaterelated Osteonecrosis of the Jaws", Trauma Mon, 19, pp.e17196~ (2014)