Effect of autogenous tooth bone graft with membrane on Class II furcation defects in dogs: A histologic and histomorphometric study
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The study evaluated the efficacy of combining autogenous tooth bone grafts with membranes in surgically created class II furcation defects. Thirty teeth of 10 dogs were assessed. Furcation defects (5 × 4 × 3 mm3) were created in the lower third and fourth premolars. Defects in the control, experimental-1, and experimental-2 groups were treated with non-resorbable membranes only, autogenous tooth bone grafts with non-resorbable membranes, and autogenous tooth bone grafts with resorbable membranes, respectively. Healing patterns were observed 4 to 8 weeks after treatment. Mesio-distal sections were obtained and stained with hematoxylin and eosin, and histological and histomorphometrical analyses were performed. Four weeks after treatment, connective tissue and autogenous tooth bone graft materials with newly formed bone were observed. Partial recovery of periodontal ligament-like tissue and formation of cementum-like tissue at root surfaces also occurred. Eight weeks after treatment, mature bone tissue formation was noted. In addition, regular thickness of cementum-like tissue at root surfaces, and improved periodontal ligament-like tissue were observed. Areas of newly formed tissue were 92.2% ± 13.0%, 97.4% ± 4.4%, and 98.1% ± 2.8% at 4 weeks after treatment, and 96.7% ± 3.7%, 96.8% ± 5.7%, and 99.6% ± 0.8% by 8 weeks post-treatment, in the control, experimental-1, and experimental-2 groups, respectively. Regeneration of defective tissues occurred in the experimental group compared with the control group, but not significantly. This study showed that combining autogenous tooth bone grafts with membranes in class II furcation defects improves healing efficiency.
Abstract
The study evaluated the efficacy of combining autogenous tooth bone grafts with membranes in surgically created class II furcation defects. Thirty teeth of 10 dogs were assessed. Furcation defects (5 × 4 × 3 mm3) were created in the lower third and fourth premolars. Defects in the control, experimental-1, and experimental-2 groups were treated with non-resorbable membranes only, autogenous tooth bone grafts with non-resorbable membranes, and autogenous tooth bone grafts with resorbable membranes, respectively. Healing patterns were observed 4 to 8 weeks after treatment. Mesio-distal sections were obtained and stained with hematoxylin and eosin, and histological and histomorphometrical analyses were performed. Four weeks after treatment, connective tissue and autogenous tooth bone graft materials with newly formed bone were observed. Partial recovery of periodontal ligament-like tissue and formation of cementum-like tissue at root surfaces also occurred. Eight weeks after treatment, mature bone tissue formation was noted. In addition, regular thickness of cementum-like tissue at root surfaces, and improved periodontal ligament-like tissue were observed. Areas of newly formed tissue were 92.2% ± 13.0%, 97.4% ± 4.4%, and 98.1% ± 2.8% at 4 weeks after treatment, and 96.7% ± 3.7%, 96.8% ± 5.7%, and 99.6% ± 0.8% by 8 weeks post-treatment, in the control, experimental-1, and experimental-2 groups, respectively. Regeneration of defective tissues occurred in the experimental group compared with the control group, but not significantly. This study showed that combining autogenous tooth bone grafts with membranes in class II furcation defects improves healing efficiency.
참고문헌 (53)
- Melcher AH, "On the repair potential of periodontal tissues", J Periodontol, 47, pp.256~260 (1976)[DOI]
- Gottlow J, "New attachment formation in the human periodontium by guided tissue regeneration. Case reports", J Clin Periodontol, 13, pp.604~616 (1986)[DOI]
- Schallhorn RG, "Combined osseous composite grafting, root conditioning, and guided tissue regeneration", Int J Periodontics Restorative Dent, 8, pp.8~31 (1988)
- Walters SP, "Comparison of porous and non-porous teflon membranes plus a xenograft in the treatment of vertical osseous defects: a clinical reentry study", J Periodontol, 74, pp.1161~1168 (2003)[DOI]
- Pontoriero R, "Guided tissue regeneration in degree II furcation-involved mandibular molars. A clinical study", J Clin Periodontol, 15, pp.247~254 (1988)[DOI]
- Pontoriero R, "Guided tissue regeneration in the treatment of furcation defects in mandibular molars. A clinical study of degree III involvements", J Clin Periodontol, 16, pp.170~174 (1989)[DOI]
- Pihlstrom BL, "Comparison of surgical and nonsurgical treatment of periodontal disease. A review of current studies and additional results after 61", 2 years, 1983, pp.10, 524~541
- Tonetti MS, "Periodontal regeneration of human intrabony defects. IV. Determinants of healing response", J Periodontol, 64, pp.934~940 (1993)[DOI]
- Machtei EE, "Successful regeneration of mandibular Class II furation defects: An evidence-based treatment approach", Int J Periodontics Restorative Dent, 15, pp.146~167 (1995)
- Nasr HF, "Bone and bone substitutes", Periodontol 2000, 19, pp.74~86 (1999)[DOI]
- Lang NP, "Clinical periodontology and implant dentistry", pp.536~555 (2015), John Wiley & Sons, Ltd
- Schallhorn RG, "Long term evaluation of osseous grafts in periodontal therapy", Int Dent J, 30, pp.101~116 (1980)
- Kim SG, "Grafting of large defects of the jaws with a particulate dentin-plaster of Paris combination", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 88, pp.22~25 (1999)[DOI]
- Yeomans JD, "Bone induction by decalcified dentine implanted into oral, osseous and muscle tissues", Arch Oral Biol, 12, pp.999~1008 (1967)[DOI]
- Bessho K, "Human dentin-matrix-derived bone morphogenetic protein", J Dent Res, 70, pp.171~175 (1991)[DOI]
- Kim YK, "An experimental study on the tissue reaction of toothash implanted in mandible body of the mature dog", Maxillofac Plast Reconstr Surg, 15, pp.129~136 (1993)
- Kim YK, "Implantation of toothash combined with plaster of Paris: experimental study", Maxillofac Plast Reconstr Surg, 16, pp.122~129 (1994)
- Kim YK, "The experimental study of the implantation of toothash and plaster of Paris and guided tissue regeneration using Lyodura", J Korean Assoc Oral Maxillofac Surg, 22, pp.297~306 (1996)
- Kim YK, "Transmitted electronic microscopic study about the tissue reaction after the implantation of toothash", J Korean Assoc Oral Maxillofac Surg, 23, pp.283~289 (1997)
- Kim YK, "An experimental study on the healing process after the implantation of various bone substitutes in the rats", J Korean Assoc Oral Maxillofac Surg, 27, pp.15~24 (2001)
- Kim YK, "Cytotoxicity and hypersensitivity test of toothash", Maxillofac Plast Reconstr Surg, 23, pp.391~395 (2001)
- Kim YK, "Development of a novel bone grafting material using autogenous teeth", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 109, pp.496~503 (2010)[DOI]
- Kim YK, "Autogenous teeth used for bone grafting: a comparison with traditional grafting materials", Oral Surg Oral Med Oral Pathol Oral Radiology, 117, pp.39~45 (2014)[DOI]
- Melcher AH, "On the repair potential of periodontal tissues", J Periodontol, 47, pp.256~260 (1976)[DOI]
- Bosshardt DD, "Does periodontal tissue regeneration really work?", Periodontol 2000, 51, pp.208~219 (2009)[DOI]
- Murphy KG, "Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects", Ann Periodontol, 8, pp.266~302 (2003)[DOI]
- Sculean A, "Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials-biological foundation and preclinical evidence: a systematic review", J Clin Periodontol, 35, pp.106~116 (2008)[DOI]
- Novaes AB Jr, "Root trunk concavities as a risk factor for regenerative procedures of Class II furcation lesions in dogs", J Periodontol, 72, pp.612~619 (2001)[DOI]
- Jones WA, "The effectiveness of in vivo root planning in removing bacterial endotoxin from the roots of periodontally involved teeth", J Periodontol, 49, pp.337~342 (1978)[DOI]
- Wikesjo UM, "Periodontal repair in dogs: healing in experimentally created chronic periodontal defects", J Periodontol, 62, pp.258~263 (1991)[DOI]
- Choi SH, "Effect of recombinant human bone morphogenetic protein-2", absorbable collagen sponge (rhBMP-2, J Periodontol, pp.2002, 73[DOI]
- Selvig KA, "Regenerative surgery of intrabony periodontal defects using ePTFE barrier membranes: scanning electron microscopic evaluation of retrieved membranes versus clinical healing", J Periodontol, 63, pp.974~978 (1992)[DOI]
- Machtei EE, "The effect of membrane exposure on the outcome of regenerative procedures in humans: a metaanalysis", J Periodontol, 72, pp.512~516 (2001)[DOI]
- Sander L, "Effect of local metronidazole application on periodontal healing following guided tissue regeneration. Clinical findings", J Periodontol, 65, pp.914~920 (1994)[DOI]
- Novaes AB, "Bacterial colonization of the external and internal sulci and of cellulose membranes at time of retrieval", J Periodontol, 66, pp.864~869 (1995)[DOI]
- Anderegg CR, "Gingiva thickness in guided tissue regeneration and associated recession at facial furcation defects", J Periodontol, 66, pp.397~402 (1995)[DOI]
- Murphy KG, "Postoperative healing complications associated with Gore-Tex periodontal material. Part I. Incidence and characterization", Int J Periodontics Restorative Dent, 15, pp.363~375 (1995)
- Murphy KG, "Postoperative healing complications associated with Gore-Tex periodontal material. Part II. Effect of complications on regeneration", Int J Periodontics Restorative Dent, 15, pp.548~561 (1995)
- Caton J, "Guided tissue regeneration in interproximal defects in the monkey", Int J Periodontics Restorative Dent, 12, pp.266~277 (1992)
- Caffesse RG, "New attachment achieved by guided tissue regeneration in beagle dogs", J Periodontol, 59, pp.589~594 (1988)[DOI]
- Deliberador TM, "Autogenous bone graft with or without a calcium sulfate barrier in the treatment of Class II furcation defects: a histologic and histometric study in dogs", J Periodontol, 77, pp.780~789 (2006)[DOI]
- Macedo GO, "Effect of early membrane removal on regeneration of Class II furcation defects in dogs", J Periodontol, 77, pp.46~53 (2006)[DOI]
- Hassan KS, "A comparative evaluation of immediate dental implant with autogenous versus synthetic guided bone regeneration", Oral Surg Oral Med oral Pathol Oral Radiol Endod, 106, pp.8~15 (2008)[DOI]
- Wallace SC, "Guided tissue regeneration with and without decalcified freezedried bone in mandibular Class II furcation invasions", J Periodontol, 65, pp.244~254 (1994)[DOI]
- Calongne KB, "Clinical comparison of microporous biocompatible composite of PMMA, PHEMA and calcium hydroxide grafts and expanded polytetrafluoroethylene barrier membranes in human mandibular molar Class II furcations. A case series", J Periodontol, 72, pp.1451~1459 (2001)[DOI]
- Luepke PG, "A clinical evaluation of a bioresorbable barrier with and without decalcified freeze-dried bone allograft in the treatment of molar furcations", J Clin Periodontol, 24, pp.440~446 (1997)[DOI]
- Caffesse RG, "Guided tissue regeneration and bone grafts in the treatment of furcation defects", J Periodontol, 64, pp.1145~1153 (1993)[DOI]
- Lekovic V, "Guided tissue regeneration using calcium phosphate implants together with 4 different membranes. A study on furcations in dogs", J Periodontol, 64, pp.1154~1156 (1993)[DOI]
- Jepsen S, "A systematic review of guided tissue regeneration for periodontal furcation defects. What is the effect of guided tissue regeneration compared with surgical debridement in the treatment of furcation defects?", J Clin Periodontol, 29, pp.103~116 (2002)
- White C, "A histomorphometric study on the healing of Class III furcations utilizing bone labelling in beagle dogs", J Periodontol, 65, pp.84~92 (1994)[DOI]
- Mombelli A, "Isolation of periodontal species after guided tissue regeneration", J Periodontol, 64, pp.1171~1175 (1993)[DOI]
- Cortellini P, "Interproximal free gingival grafts after membrane removal in guided tissue regeneration treatment of intrabony defects. A randomized controlled clinical trial", J Periodontol, 66, pp.488~493 (1995)[DOI]
- Behfarnia P, "Histological and histomorphometric analysis of animal experimental dehiscence defect treated with three bio absorbable GTR collagen membrane", Dent Res J, 9, pp.574~581 (2012)[DOI]
