국내 양돈 상업품종의 유전체 및 혈통 기반 근교수준 비교
Comparative Evaluation of Inbreeding Parameters in Korean Commercial Pig Breeds Using Genomic and Pedigree Information
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초록
본 연구는 국내의 세 품종 돼지에 대하여 혈통자료를 이용한 근교계수와 유전체자료를 이용한 근교계수를 분석하고 비교하기 위하여 수행되었다. 분석에 이용된 혈통자료는 듀록, 랜드레이스 및 요크셔 종에서 각각 137,302두, 228,651두와 657,079두였고, 유전체자료의 경우 Illumina PorcineSNP 60K bead chip V2를 이용하여 수집하였으며 세 품종에서 각각 2,567개, 7,594개 및 12,906개의 자료를 이용하였다. 듀록, 랜드레이스와요크셔에서 혈통자료를 이용하여 추정된 근교계수는 각각 0.04, 0.02 및 0.02였으며, 유전체자료를 이용하여 추정된 근교계수는 각각 0.184, 0.098및 0.063이었다. 듀록에서 두 근교계수의 상관이 0.466으로 가장 높게 나타났다. 본 연구를 통하여 혈통완성도는 유전체 정보를 이용하여 보완할수 있음이 확인되었으며, 유전체 정보는 집단의 유전자원 관리에도 활용도가 높아 국내 양돈산업의 근친도 관리에서 중요한 역할을 할 것으로기대된다.
Abstract
This study was conducted to analyze and compare pedigree-based inbreeding coefficients (Fped) and genomic inbreeding coefficients(Froh) for three domestic pig breeds in Korea. Pedigree data were collected 137,302, 228,651, and 657,079 individuals, Duroc, Landrace,and Yorkshire breeds. After quality contron, genomic information (SNPs) were used 2,567(30,885), 7,594(25,864), and 12,906(21,335)individuals for each breed. Fped were 0.04, 0,02 and 0.02 in Duroc, Landrace and Yorkshire breeds, respectively. Froh were 0.184,0.098 and 0.063 in each breed. The correlation between the Fped and Froh was highest in the Duroc breed at 0.466. This study hasconfirmed the potential to complement pedigree completeness using genomic information. Genomic information are expected a significantrole not only in the management of genetic resources within populations but also in the crucial task of inbreeding management withinthe domestic swine industry in Korea.
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