직류전류자극의 경부 적용이 피질척수로의 흥분도에 미치는 영향 연구
Cervical Application of the Direct Current Stimulation: Effects on Corticospinal Excitability
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Objectives: To estimate the effects of the direct current (DC) stimulation applied at the cervical region on corticospinal excitability Methods: 11 healthy volunteers (26.8±3.31Yrs) participated in this study. A weak direct current (2 mA) was delivered on their cervical region using a constant current stimulator for 20 minutes. The magnetic stimulation was applied over the primary motor cortex and motor evoked potential (MEP) was measured at the abductor pollicis brevis (APB) muscle. Experimental protocol was composed of 3 sessions according to directions of the application; Anterior neck anode/posterior neck cathode (AC) stimulation, Anterior cathode/posterior anode (CA) stimulation and Sham stimulation. The MEP amplitudes were measured before, during and after the DC stimulation. Results: Within AC stimulation and CA stimulation, each of MEP amplitude during stimulation and after the stimulation was significantly different from the initial amplitude. Between sessions, both of AC and CA stimulations were significantly different from Sham stimulation (P value<0.01), but it was not between AC and CA stimulation. Conclusion: Cervical application of the DC stimulation increased the corticospinal excitability. This effect maintained at least 10 minutes after stop of the stimulation. It might be effective tool for the corticospinal tract excitation.
Abstract
Objectives: To estimate the effects of the direct current (DC) stimulation applied at the cervical region on corticospinal excitability Methods: 11 healthy volunteers (26.8±3.31Yrs) participated in this study. A weak direct current (2 mA) was delivered on their cervical region using a constant current stimulator for 20 minutes. The magnetic stimulation was applied over the primary motor cortex and motor evoked potential (MEP) was measured at the abductor pollicis brevis (APB) muscle. Experimental protocol was composed of 3 sessions according to directions of the application; Anterior neck anode/posterior neck cathode (AC) stimulation, Anterior cathode/posterior anode (CA) stimulation and Sham stimulation. The MEP amplitudes were measured before, during and after the DC stimulation. Results: Within AC stimulation and CA stimulation, each of MEP amplitude during stimulation and after the stimulation was significantly different from the initial amplitude. Between sessions, both of AC and CA stimulations were significantly different from Sham stimulation (P value<0.01), but it was not between AC and CA stimulation. Conclusion: Cervical application of the DC stimulation increased the corticospinal excitability. This effect maintained at least 10 minutes after stop of the stimulation. It might be effective tool for the corticospinal tract excitation.
참고문헌 (32)
- Bindman LJ, "The Action of Brief Polarizing Currents on the Cerebral Cortex of the Rat (1) during Current Flow and (2) in the Production of Long-Lasting after-Effects", J Physiol, 172, pp.369~382 (1964)
- Bindman LJ, "Long-lasting changes in the level of the electrical activity of the cerebral cortex produced bypolarizing currents", Nature, 196, pp.584~585 (1962)
- Terzuolo CA, "Measurement of Imposed Voltage Gradient Adequate to Modulate Neuronal Firing", Proc Natl Acad Sci U S A, 42, pp.687~694 (1956)
- Artola A, "Different voltage-dependent thresholds for inducing long-term depression and long-term potentiation in slices of rat visual cortex", Nature, 347, pp.69~72 (1990)
- Creutzfeldt OD, "Influence of transcortical d-c currents on cortical neuronal activity", Exp Neurol, 5, pp.436~452 (1962)
- Boros K, "Premotor transcranial direct current stimulation (tDCS) affects primary motor excitability in humans", Eur J Neurosci, 27, pp.1292~1300 (2008)
- Boggio PS, "Repeated sessions of noninvasive brain DC stimulation is associated with motor function improvement in stroke patients", Restor Neurol Neurosci, 25, pp.123~129 (2007)
- Boggio PS, "Enhancement of non-dominant hand motor function by anodal transcranial direct current stimulation", Neurosci Lett, 404, pp.232~236 (2006)
- Hummel F, "Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke", Brain, 128, pp.490~499 (2005)
- Fregni F, "Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory", Exp Brain Res, 166, pp.23~30 (2005)
- Boggio PS, "Modulation of emotions associated with images of human pain using anodal transcranial direct current stimulation (tDCS)", Neuropsychologia (2008)
- Bikson M, "Transcranial direct current stimulation for major depression: a general system for quantifying transcranial electrotherapy dosage", Curr Treat Options Neurol, 10, pp.377~385 (2008)
- Antal A, "Transcranial direct current stimulation over somatosensory cortex decreases experimentally induced acute pain perception", Clin J Pain, 24, pp.56~63 (2008)
- Lang N, "How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain", Eur J Neurosci, 22, pp.495~504 (2005)
- Baudewig J, "Regional modulation of BOLD MRI responses to human sensorimotor activation by transcranial direct current stimulation", Magn Reson Med, 45, pp.196~201 (2001)
- Nitsche MA, "Level of action of cathodal DC polarisation induced inhibition of the human motor cortex", Clin Neurophysiol, 114, pp.600~604 (2003)
- Nitsche MA, "Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans", Neurology, 57, pp.1899~1901 (2001)
- Wallace MC, "Recovery of spinal cord function induced by direct current stimulation of the injured rat spinal cord", Neurosurgery, 20, pp.878~884 (1987)
- Fehlings MG, "The effect of direct current field polarity on recovery after acute experimental spinal cord injury", Brain Res, 579, pp.32~42 (1992)
- Huang H, "Modulation effects of epidural spinal cord stimulation on muscle activities during walking", IEEE Trans Neural Syst Rehabil Eng, 14, pp.14~23 (2006)
- Carhart MR, "Epidural spinal-cord stimulation facilitates recovery of functional walking following incomplete spinal-cord injury", IEEE Trans Neural Syst Rehabil Eng, 12, pp.32~42 (2004)
- Tealdi DG, "Epidural spinal electric stimulation in the treatment of ischemic pain", Int Angiol, 6, pp.435~437 (1987)
- Kumar K, "Epidural spinal cord stimulation for treatment of chronic pain--some predictors of success. A 15-year experience", Surg Neurol, 50, pp.110~120 (1998)
- Lang P, "The treatment of chronic pain by epidural spinal cord stimulation--a 15 year follow up; present status", Axone, 18, pp.71~73 (1997)
- Broggi G, "Italian multicentric study on pain treatment with epidural spinal cord stimulation", Stereotact Funct Neurosurg, 62, pp.273~278 (1994)
- Shimoji K, "Management of intractable pain with percutaneous epidural spinal cord stimulation: differences in pain-relieving effects among diseases and sites of pain", Anesth Analg, 77, pp.110~116 (1993)
- Kumar K, "Treatment of chronic pain by epidural spinal cord stimulation: a 10-year experience", J Neurosurg, 75, pp.402~407 (1991)
- Jung SH, "Changes in motor cortical excitability induced by high-frequency repetitive transcranial magnetic stimulation of different stimulation durations", Clin Neurophysiol, pp.71~79 (2008)
- McIntyre CC, "Extracellular stimulation of central neurons: influence of stimulus waveform and frequency on neuronal output", J Neurophysiol, 88, pp.1592~1604 (2002)
- Durand DM, "Electric field effects in hyperexcitable neural tissue: a review", Radiat Prot Dosimetry, 106, pp.325~331 (2003)
- Tranchina D, "A model for the polarization of neurons by extrinsically applied electric fields", Biophys J, 50, pp.1139~1156 (1986)
- Taylor JL, "Noninvasive stimulation of the human corticospinal tract", J Appl Physiol, 96, pp.1496~1503 (2004)