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다제내성 결핵 환자에서 장기간 Linezolid 복용에 의해 유발된 말초성 다발신경병 1예

Linezolid-Induced Peripheral Polyneuropathy in a Multidrug-Resistant Tuberculosis Patient - A Case Report -

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초록

Linezolid is an antibiotic with antimycobacterial activity and used for patients with highly drug-resistant tuberculosis. Peripheral neuropathy is a rare adverse effect of linezolid therapy. However, there has not been a report of peripheral neuropathy caused by linezolid in a multidrug-resistant tuberculosis patient, domestically. We present a case of linezolidinduced peripheral neuropathy in drug-resistant tuberculosis. The patient complained of neuropathic pain and abnormal sensory symptom after treatment of linezolid and the symptoms were reduced after discontinue of linezolid.

Abstract

Linezolid is an antibiotic with antimycobacterial activity and used for patients with highly drug-resistant tuberculosis. Peripheral neuropathy is a rare adverse effect of linezolid therapy. However, there has not been a report of peripheral neuropathy caused by linezolid in a multidrug-resistant tuberculosis patient, domestically. We present a case of linezolidinduced peripheral neuropathy in drug-resistant tuberculosis. The patient complained of neuropathic pain and abnormal sensory symptom after treatment of linezolid and the symptoms were reduced after discontinue of linezolid.

참고문헌 (11)

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  8. Bressler AM, "Peripheral neuropathy associated with prolonged use of linezolid", The Lancet Infectious diseases, 4, pp.528~531 (2004)
  9. Ferry T, "Possibly linezolid-induced peripheral and central neurotoxicity: report of four cases", Infection, 33, pp.151~154 (2005)
  10. Rho JP, "Linezolid-associated peripheral neuropathy", Mayo Clinic proceedings, 79, pp.927~930 (2004)
  11. Nambiar S, "Linezolid-associated peripheral and optic neuropathy in children", Pediatrics, 127, pp.e528~e532 (2011)

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