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Immune-Mediated Necrotizing Myopathy: A Review for Clinicians

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초록

Immune-mediated necrotizing myopathy (IMNM) is a group of inflammatory myopathies showing necrotic and regenerating fibers without noteworthy inflammatory cell infiltration on pathology. The pathologic findings are different from those of dermatomyositis or sporadic inclusion body myositis. Furthermore, the discovery of myositis-specific antibodies in patients with IMNM, such as anti-signal recognition particle or anti-3-hydroxy-3-methylglutaryl-CoA reductase antibodies, has enabled us to expand our knowledge of IMNM. However, the phenotype and pathological findings of IMNM are unremarkable; therefore, it is difficult to diagnose, and IMNM has been relatively unrecognized. In this review, we introduce the clinical features, diagnosis, pathomechanism, and treatment of IMNM for clinicians.

Abstract

Immune-mediated necrotizing myopathy (IMNM) is a group of inflammatory myopathies showing necrotic and regenerating fibers without noteworthy inflammatory cell infiltration on pathology. The pathologic findings are different from those of dermatomyositis or sporadic inclusion body myositis. Furthermore, the discovery of myositis-specific antibodies in patients with IMNM, such as anti-signal recognition particle or anti-3-hydroxy-3-methylglutaryl-CoA reductase antibodies, has enabled us to expand our knowledge of IMNM. However, the phenotype and pathological findings of IMNM are unremarkable; therefore, it is difficult to diagnose, and IMNM has been relatively unrecognized. In this review, we introduce the clinical features, diagnosis, pathomechanism, and treatment of IMNM for clinicians.

참고문헌 (29)

  1. Bohan A, "Polymyositis and dermatomyositis(first of two parts)", N Engl J Med, 292, pp.344~347 (1975)
  2. Lundberg IE, "Classification of myositis", Nat Rev Rheumatol, 14, pp.269~278 (2018)
  3. Amato AA, "Unicorns, dragons, polymyositis, and other mythological beasts", Neurology, 61, pp.288~289 (2003)
  4. Pinal-Fernandez I, "Immune-mediated necrotizing myopathy", Curr Rheumatol Rep, 20, pp.21~ (2018)
  5. Allenbach Y, "224th ENMC International Workshop: clinico-sero-pathological classification of immune-mediated necrotizing myopathies Zandvoort, The Netherlands, 14-16 October 2016", Neuromuscul Disord, 28, pp.87~99 (2018)
  6. Okada N, "Characterization of human autoantibodies that selectively precipitate the 7SL RNA component of the signal recognition particle", J Immunol, 138, pp.3219~3223 (1987)
  7. Christopher-Stine L, "A novel autoantibody recognizing 200-kd and 100-kd proteins is associated with an immune-mediated necrotizing myopathy", Arthritis Rheum, 62, pp.2757~2766 (2010)
  8. Mammen AL, "Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy", Arthritis Rheum, 63, pp.713~721 (2011)
  9. Meyer A, "Incidence and prevalence of inflammatory myopathies : a systematic review", Rheumatology(Oxford), 54, pp.50~63 (2015)
  10. 조수경, "Incidence and Prevalence of Idiopathic Inflammatory Myopathies in Korea: a Nationwide Population-based Study", Journal of Korean Medical Science, 34(8), pp.1~11 (2019), 대한의학회
  11. Allenbach Y, "Immune-mediated necrotizing myopathy : clinical features and pathogenesis", Nat Rev Rheumatol, 16, pp.689~701 (2020)
  12. Liang WC, "Pediatric necrotizing myopathy associated with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies", Rheumatology(Oxford), 56, pp.287~293 (2017)
  13. Ge Y, "Clinical characteristics of anti-3-hydroxy-3-methylglutaryl coenzyme A reductase antibodies in Chinese patients with idiopathic inflammatory myopathies", PLoS One, 10, pp.e0141616~ (2015)
  14. Suzuki S, "Inflammatory myopathy with anti-signal recognition particle antibodies : case series of 100 patients", Orphanet J Rare Dis, 10, pp.61~ (2015)
  15. Watanabe Y, "Clinical features and prognosis in anti-SRP and anti-HMGCR necrotising myopathy", J Neurol Neurosurg Psychiatry, 87, pp.1038~1044 (2016)
  16. Kurashige T, "Anti-HMGCR myopathy : clinical and histopathological features, and prognosis", Curr Opin Rheumatol, 33, pp.554~562 (2021)
  17. Pinal-Fernandez I, "Longitudinal course of disease in a large cohort of myositis patients with autoantibodies recognizing the signal recognition particle", Arthritis Care Res(Hoboken), 69, pp.263~270 (2017)
  18. Yang H, "Clinical and pathological features of immune-mediated necrotising myopathies in a single-centre muscle biopsy cohort", BMC Musculoskelet Disord, 23, pp.425~ (2022)
  19. Allenbach Y, "High risk of cancer in autoimmune necrotizing myopathies: usefulness of myositis specific antibody", Brain, 139(Pt 8), pp.2131~2135 (2016)
  20. Tiniakou E, "More severe disease and slower recovery in younger patients with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase-associated autoimmune myopathy", Rheumatology(Oxford), 56, pp.787~794 (2017)
  21. Mammen AL, "Statin-associated autoimmune myopathy", N Engl J Med, 374, pp.664~669 (2016)
  22. Landon-Cardinal O, "Severe axial and pelvifemoral muscle damage in immune-mediated necrotizing myopathy evaluated by whole-body MRI", Semin Arthritis Rheum, 50, pp.1437~1440 (2020)
  23. Pinal-Fernandez I, "Thigh muscle MRI in immune-mediated necrotising myopathy : extensive oedema, early muscle damage and role of anti-SRP autoantibodies as a marker of severity", Ann Rheum Dis, 76, pp.681~687 (2017)
  24. Benveniste O, "Correlation of anti-signal recognition particle autoantibody levels with creatine kinase activity in patients with necrotizing myopathy", Arthritis Rheum, 63, pp.1961~1971 (2011)
  25. Arouche-Delaperche L, "Pathogenic role of anti-signal recognition protein and anti-3-Hydroxy-3-methylglutaryl-CoA reductase antibodies in necrotizing myopathies : myofiber atrophy and impairment of muscle regeneration in necrotizing autoimmune myopathies", Ann Neurol, 81, pp.538~548 (2017)
  26. Bergua C, "In vivo pathogenicity of IgG from patients with anti-SRP or anti-HMGCR autoantibodies in immune-mediated necrotising myopathy", Ann Rheum Dis, 78, pp.131~139 (2019)
  27. Rademacher JG, "Treatment and outcomes in anti-HMG-CoA reductase-associated immune-mediated necrotising myopathy : comparative analysis of a single-centre cohort and published data", Clin Exp Rheumatol, 40, pp.320~328 (2022)
  28. Landon-Cardinal O, "Rituximab in the treatment of refractory anti-HMGCR immune-mediated necrotizing myopathy", J Rheumatol, 46, pp.623~627 (2019)
  29. Binns EL, "Effective induction therapy for anti-SRP associated myositis in childhood : a small case series and review of the literature", Pediatr Rheumatol Online J, 15, pp.77~ (2017)

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