Research on the Pathogenesis of Hemifacial Spasm through Electrophysiological Studies
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The cause of hemifacial spasm (HFS) is commonly linked to vascular compression of the facial nerve at the root exit zone. Microvascular decompression has become the most effective treatment for HFS. However, despite numerous electrophysiological studies investigating factors such as ephaptic transmission, ectopic excitation between individual nerve fibers, and hyperexcitability of the facial motor nucleus, there is still debate about the exact pathogenesis of HFS. For over 40 years, researchers have been conducting electrophysiological studies in clinical settings to better understand the pathogenesis of HFS. These studies have employed techniques including the lateral spread response, blink reflex test, facial F-waves, and transcranial electrical stimulation. Although a peripheral nerve mechanism was historically considered most likely to be responsible for this condition, recent studies are increasingly pointing to a central mechanism as the primary culprit behind HFS. This article seeks to shed light on the pathogenesis of HFS by reviewing the key findings from electrophysiological studies carried out over the years.
Abstract
The cause of hemifacial spasm (HFS) is commonly linked to vascular compression of the facial nerve at the root exit zone. Microvascular decompression has become the most effective treatment for HFS. However, despite numerous electrophysiological studies investigating factors such as ephaptic transmission, ectopic excitation between individual nerve fibers, and hyperexcitability of the facial motor nucleus, there is still debate about the exact pathogenesis of HFS. For over 40 years, researchers have been conducting electrophysiological studies in clinical settings to better understand the pathogenesis of HFS. These studies have employed techniques including the lateral spread response, blink reflex test, facial F-waves, and transcranial electrical stimulation. Although a peripheral nerve mechanism was historically considered most likely to be responsible for this condition, recent studies are increasingly pointing to a central mechanism as the primary culprit behind HFS. This article seeks to shed light on the pathogenesis of HFS by reviewing the key findings from electrophysiological studies carried out over the years.
참고문헌 (23)
- Gardner WJ, "Concerning the mechanism of trigeminal neuralgia and hemifacial spasm", J Neurosurg, 19, pp.947~958 (1962)
- Jannetta PJ, "Etiology and definitive microsurgical treatment of hemifacial spasm: operative techniques and results in 47 patients", J Neurosurg, 47, pp.321~328 (1977)
- Nielsen VK, "Pathophysiology of hemifacial spasm: I. Ephaptic transmission and ectopic excitation", Neurology, 34, pp.418~426 (1984)
- Nielsen VK, "Pathophysiology of hemifacial spasm: II. Lateral spread of the supraorbital nerve reflex", Neurology, 34, pp.427~431 (1984)
- Nielsen VK, "Pathophysiology of hemifacial spasm: III. Effects of facial nerve decompression", Neurology, 34, pp.891~897 (1984)
- Nielsen VK, "Electrophysiology of the facial nerve in hemifacial spasm : ectopic", ephaptic excitation, 1985, pp.8, 545~555
- Kameyama S, "Ephaptic transmission is the origin of the abnormal muscle response seen in hemifacial spasm", Clin Neurophysiol, 127, pp.2240~2245 (2016)
- Ferguson JH, "Hemifacial spasm and the facial nucleus", Ann Neurol, 4, pp.97~103 (1978)
- Møller AR, "On the origin of synkinesis in hemifacial spasm: results of intracranial recordings", J Neurosurg, 61, pp.569~576 (1984)
- Esteban A, "Molina-Negro P : Primary hemifacial spasm : a neurophysiological study", J Neurol Neurosurg Psychiatry, 49, pp.58~63 (1986)
- Ishikawa M, "Electrophysiological investigation of hemifacial spasm : F-waves of the facial muscles", Acta Neurochir(Wien), 138, pp.24~32 (1996)
- Yamashita S, "Lateral spread response elicited by double stimulation in patients with hemifacial spasm", Muscle Nerve, 25, pp.845~849 (2002)
- Wilkinson MF, "Facial motor neuron excitability in hemifacial spasm: a facial MEP study", Can J Neurol Sci, 41, pp.239~245 (2014)
- Kugelberg E, "Facial reflexes", Brain, 75, pp.385~396 (1952)
- Eekhof JL, "Blink reflexes and lateral spreading in patients with synkinesia after Bell’s palsy and in hemifacial spasm", Eur Neurol, 43, pp.141~146 (2000)
- Valls-Solé J, "Facial nerve palsy and hemifacial spasm", Handb Clin Neurol, 115, pp.367~380 (2013)
- Møller AR, "Blink reflex in patients with hemifacial spasm: observations during microvascular decompression operations", J Neurol Sci, 72, pp.171~182 (1986)
- Ishikawa M, "Toya S : Abnormal muscle response(lateral spread)and F-wave in patients with hemifacial spasm", J Neurol Sci, 137, pp.109~116 (1996)
- Hai J, "Experimental study on the correlation between abnormal muscle responses and F waves in hemifacial spasm", Neurol Res, 29, pp.553~556 (2007)
- Rasminsky M, "Ephaptic transmission between single nerve fibres in the spinal nerve roots of dystrophic mice", J Physiol, 305, pp.151~169 (1980)
- Ishikawa M, "Electrophysiological investigation of hemifacial spasm after microvascular decompression: F waves of the facial muscles, blink reflexes, and abnormal muscle responses", J Neurosurg, 86, pp.654~661 (1997)
- Wilkinson MF, "Monitoring of facial muscle motor evoked potentials during microvascular decompression for hemifacial spasm: evidence of changes in motor neuron excitability", J Neurosurg, 103, pp.64~69 (2005)
- Wilkinson MF, "Analysis of facial motor evoked potentials for assessing a central mechanism in hemifacial spasm", J Neurosurg, 126, pp.379~385 (2017)