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Characteristics of Microorganisms Isolated from Blood Cultures at Nine University Hospitals in Korea during 2009

김선주|김미나|조지현|이남용|신정환|김재석|김희정|김의종|류남희|구선회
대한임상미생물학회 (Korean Society of Clinical Microbiology)|2011.06|Annals of Clinical Microbiology|제14권 제2호|pp. 48-54

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참고문헌

키워드

Antimicrobial susceptibilityBacteremiaBlood cultureFungemia

초록

Background: Blood culture is important for determining the etiologic agents of bacteremia and fungemia. Analyses of blood culture results and antimicrobial susceptibility can provide clinicians with relevant information for the empirical treatment of patients. The present study was conducted to assess the frequencies and antimicrobial resistance patterns of clinically important microorganisms from nine hospitals. Methods: Data including microbiological isolates and corresponding antimicrobial susceptibility test results were collected during 2009 from nine and five university hospitals, respectively. Microorganism identification was based on conventional methods. Antimicrobial susceptibility was tested using the VITEK II system or the Clinical and Laboratory Standards Institute disk diffusion method. Results: Of 397,602 blood specimens cultured from nine hospitals, 34,708 (8.7%) were positive for microorganisms. Excluding coagulase-negative Staphylococci (CoNS), Escherichia coli was the most common isolate (13.5%), followed by Staphylococcus aureus (11.5%), Klebsiella pneumoniae (6.5%) and Enterococcus faecium (3.4%). The isolation rate of CoNS was 23.6%, while that of ceftazidime-resistant E. coli showed geographic differences ranging from 11% to 28%. Among the Gram-negative isolates, A.baumannii displayed the highest levels of resistance. The total isolation rate of the Candida species increased compared to the previous reported rate in Korea. Conclusion: Among the isolates, CoNS was the most common, followed by E. coli and S. aureus. The gradual increase in the prevalence of extended-spectrum β-lactamase (ESBL) producers has contributed to the increase in multi-drug resistance among bacterial isolates from bloodstream infections.

Abstract

Background: Blood culture is important for determining the etiologic agents of bacteremia and fungemia. Analyses of blood culture results and antimicrobial susceptibility can provide clinicians with relevant information for the empirical treatment of patients. The present study was conducted to assess the frequencies and antimicrobial resistance patterns of clinically important microorganisms from nine hospitals. Methods: Data including microbiological isolates and corresponding antimicrobial susceptibility test results were collected during 2009 from nine and five university hospitals, respectively. Microorganism identification was based on conventional methods. Antimicrobial susceptibility was tested using the VITEK II system or the Clinical and Laboratory Standards Institute disk diffusion method. Results: Of 397,602 blood specimens cultured from nine hospitals, 34,708 (8.7%) were positive for microorganisms. Excluding coagulase-negative Staphylococci (CoNS), Escherichia coli was the most common isolate (13.5%), followed by Staphylococcus aureus (11.5%), Klebsiella pneumoniae (6.5%) and Enterococcus faecium (3.4%). The isolation rate of CoNS was 23.6%, while that of ceftazidime-resistant E. coli showed geographic differences ranging from 11% to 28%. Among the Gram-negative isolates, A.baumannii displayed the highest levels of resistance. The total isolation rate of the Candida species increased compared to the previous reported rate in Korea. Conclusion: Among the isolates, CoNS was the most common, followed by E. coli and S. aureus. The gradual increase in the prevalence of extended-spectrum β-lactamase (ESBL) producers has contributed to the increase in multi-drug resistance among bacterial isolates from bloodstream infections.

참고문헌 (28)

  1. National Nosocomial Infections Surveillance System, "National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004", Am J Infect Control, 32, pp.470~485 (2004)
  2. Edmond MB, "Nosocomial bloodstream infections in United States hospitals: a three-year analysis", Clin Infect Dis, 29, pp.239~244 (1999)
  3. Diekema DJ, "SENTRY Participants Group. Age-related trends in pathogen frequency and antimicrobial susceptibility of bloodstream isolates in North America: SENTRY Antimicrobial Surveillance Program, 1997∼2000", Int J Antimicrob Agents, 20, pp.412~418 (2002)
  4. Smith TL, "Antimicrobial resistance in Staphylococcus aureus", Microbes Infect, 1, pp.795~805 (1999)
  5. Diekema DJ, "Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997-1999", Clin Infect Dis, 32(2), pp.114~132 (2001), SENTRY Partcipants Group
  6. Doern GV, "Multicenter evaluation of the in vitro activity of six broad-spectrum beta-lactam antimicrobial agents in Puerto Rico", Diagn Microbiol Infect Dis, 30, pp.113~119 (1998), The Puerto Rico Antimicrobial Resistance Study Group
  7. Diekema DJ, "Survey of bloodstream infections due to gram-negative bacilli: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, and Latin America for the SENTRY Antimicrobial Surveillance Program, 1997", Clin Infect Dis, 29, pp.595~607 (1999)
  8. Heinemann B, "Comparative activities of ciprofloxacin, clinafloxacin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against epidemiologically defined Acinetobacter baumannii strains", Antimicrob Agents Chemother, 44, pp.2211~2213 (2000)
  9. Diekema DJ, "Epidemiology of candidemia: 3-year results from the emerging infections and the epidemiology of Iowa organisms study", J Clin Microbiol, 40, pp.1298~1302 (2002)
  10. Hajjeh RA, "Incidence of bloodstream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population-based active surveillance program", J Clin Microbiol, 42, pp.1519~1527 (2004)
  11. National Committee for Clinical Laboratory Standards, "Performance standards for antimicrobial susceptibility testing. Twenlfth informational supplement, M100-S20", National Committee for Clinical Laboratory Standards, ~ (2010)
  12. 고은미, "1994-2003년 한 대학병원 혈액배양에서 분리된 미생물의 분포 및세균의 항균제 감수성 양상", Annals of Laboratory Medicine, 27(4), pp.265~275 (2007), 대한진단검사의학회
  13. 강성하, "Characteristics of Microorganisms Isolated from Blood Cultures at a University Hospital Located in an Island Region During 2003∼2007", 대한임상미생물학회지, 11(1), pp.11~17 (2008), 대한임상미생물학회
  14. 안균열, "환자의 혈액배양에서 분리된 균종과 항균제 감수성의 변화추이", 대한임상미생물학회지, 9(1), pp.42~50 (2006), 대한임상미생물학회
  15. Cockerill FR 3rd, "Optimal testing parameters for blood cultures", Clin Infect Dis, 38, pp.1724~1730 (2004)
  16. Hall KK, "Updated review of blood culture contamination", Clin Microbiol Rev, 19, pp.788~802 (2006)
  17. Bates DW, "Contaminant blood cultures and resource utilization. The true consequences of false-positive results", JAMA, 265, pp.365~369 (1991)
  18. Shafazand S, "Blood cultures in the critical care unit: improving utilization and yield", Chest, 122, pp.1727~1736 (2002)
  19. Souvenir D, "Blood cultures positive for coagulase-negative staphylococci: antisepsis, pseudobacteremia, and therapy of patients", J Clin Microbiol, 36, pp.1923~1926 (1998)
  20. Bryan CS, "Clinical implications of positive blood cultures", Clin Microbiol Rev, 2, pp.329~353 (1989)
  21. 이진솔, "Species Distribution and Susceptibility to Azole Antifungals of Candida Bloodstream Isolates from Eight University Hospitals in Korea", Yonsei Medical Journal, 48(5), pp.779~786 (2007), 연세대학교의과대학
  22. Weinstein MP, "The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults", Clin Infect Dis, 24, pp.584~602 (1997)
  23. 김소영, "일개 대학병원의 5년간 혈액 배양에 대한 분석(2003∼2007)", 대한임상미생물학회지, 12(4), pp.163~168 (2009), 대한임상미생물학회
  24. 이경원, "High Prevalence of Ceftazidime-Resistant Klebsiella pneumoniae and Increase of Imipenem-Resistant", Yonsei Medical Journal, 47(5), pp.634~645 (2006), 연세대학교의과대학
  25. Song JH, "High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study)", Antimicrob Agents Chemother, 48, pp.2101~2107 (2004)
  26. 서일혜, "개정된 Penicillin Breakpoints (CLSI M100-S18)에 따른 폐렴알균의 Penicillin 감수성률 변화", 대한임상미생물학회지, 13(2), pp.68~72 (2010), 대한임상미생물학회
  27. Centers for Disease Control and Prevention (CDC), "Effects of new penicillin susceptibility breakpoints for Streptococcus pneumoniae--United States, 2006∼2007", MMWR Morb Mortal Wkly Rep, 57, pp.1353~1355 (2008)
  28. Hong SG, "Prevalence & diversity of extended-spectrum beta-lactamase- producing Escherichia coli and Klebsiella pneumoniae isolates in Korea", Korean J Clin Microbiol, 6, pp.149~155 (2003)

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