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Carbapenem 내성 Acinetobacter baumannii

Carbapenem-Resistant Acinetobacter baumannii

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참고문헌

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초록

국내에서 분리되는 Acinetobacter의 항균제 내성률은 외국에 비해서 높으며, 다약제 내성인 세균도 흔하다. 2008년 전국 19개 병원에서 수집한 Acinetobacter baumannii 405주 중 67% (272주)가 imipenem 혹은 meropenem에 중간 혹은 내성이었다. 우리나라의 A. baumannii가 carbapenem 내성을 획득하는 주요 기전이 OXA-23 생성 혹은 OXA-51 과량생성인데 반하여 non-baumannii Acinetobacter의 주요 기전은 metallo-β-lactamase 생성이다. 국내에서 분리되는 carbapenem 내성 A. baumannii는 모두 clonal complex 92에 속하는 worldwide clone 2이다.

Abstract

Clinical isolates of Acinetobacter spp. in Korea exhibit higher antimicrobial resistance rates than in foreign countries and frequently show multi-drug resistance. Approximately 67% (272/405) of Acinetobacter baumannii isolates collected from 19 hospitals in Korea in 2008 exhibited intermediate susceptibility or resistance to imipenem and/or meropenem. The most important mechanisms in acquiring carbapenem resistance in A. baumannii in Korea are production of OXA-23 and overproduction of OXA-51, while that in non-baumannii Acinetobacter is the production of metallo-β-lactamases. All the carbapenem-resistant A. baumannii isolates were identified as clonal complex 92 and belonged to worldwide clone 2.

참고문헌 (36)

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