본문 바로가기
KERD
논문KCI 등재

대전지역에서 분리된 Helicobacter pylori의 항균제 내성율

The Prevalence of Antimicrobial Resistance in Helicobacter pylori Isolated in Daejeon

김범수|김윤미|최용우|이재학|김선문|이종욱|임의혁
대한임상미생물학회 (Korean Society of Clinical Microbiology)|2005.04|Annals of Clinical Microbiology|제8권 제1호|pp. 47-50

1

조회

0

다운로드

6

인용

0

참고문헌

초록

배경：Helicobacter pylori에 의한 소화성궤양은 항균제가 포함된 삼제요법 등의 적절한 약제로 완치가가능하다. 최근 항균제에 대한 내성이 증가되고 있고, 이로 인한 치료의 실패와 재발 등이 보고되고 있다. 저자 등은 대전지역에서 분리된 H. pylori 균주를 대상으로 항균제 감수성 양상을 조사하였다. 방법：2004년 3월부터 7월까지 건양대병원 소화기내과 환자의 위생검에서 분리된 H. pylori 31주를 대상으로 하였다. 항균제감수성검사는 E-test로 시행하였고, 배지는 triphenyltetrazolium이 첨가된 Egg Yolk 배지를 사용하였다. Amoxicillin, metronidazole 및 clarithromycin에 대해 감수성검사를 시행하였고 항균제 내성 기준은 각각 0.5㎍/mL, 8㎍/mL 및 1㎍/mL 이상으로 하였다. 결과：Amoxicillin에 대한 내성율은 7.4% (2/27), metronidazole에 대한 내성율은 25.8% (8/31), clarithromycin에 대한 내성율은 3.6% (1/28)이었다. 결론：Amoxicillin과 clarithromycin에 대한 내성균은 드물게 분리되어 국내에서 보고된 타지역의 항균제 내성율보다 낮았다.

Abstract

Background: The most commonly used regimen for the eradication of Helicobacter pylori is combination of a proton pump inhibitor, clarithromycin, and two other antibiotics, metronidazole and amoxicillin. The increase in resistance to antibiotics seems to result in a decrease in eradication efficacy for H. pylori. We investigated the prevalence of antibiotic resistance in H. pylori isolated in Daejeon area. Methods: A total of 31 clinical isolates of H. pylori were collected from the patients who underwent upper gastrointestinal endoscopy in Keonyang University Hospital during the period from March to July 2004. Antibiotic susceptibility tests for metronidazole, amoxicillin, and clarithromycin were performed by the E test (AB Biodisk, Sweden) on an egg yolk medium containing triphenyltetrazolium. The resistance break points for amoxicillin, metronidazole, and clarithromycin were defined as 0.5 ㎍/mL, 8㎍/mL, 1 ㎍/mL, respectively. Results: Resistance to amoxicillin, metronidazole, and clarithromycin was detected in 7.4% (2/27), 25.8% (8/31), 3.6% (1/28), respectively. Conclusion:The resistance to amoxicillin and clarithromycin was uncommon in Daejeon area.

참고문헌 (21)

  1. "Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer:a model", 113, pp.1983~91 (1997)
  2. "Helicobacter pylori in peptic ulcer disease", 272, pp.65~9 (1994)
  3. "Ecology of Helicobacter pylori in the human stomach", 100, pp.759~62 (1997)
  4. "Epidemiology and mechanism of antibiotic resistance in Helicobacter pylori", 115, pp.1278~82 (1998)
  5. "The HOMER study:the effect of increasing the dose of metronidazole when given with omeprazole and amoxicillin to cure Helicobacter pylori infection", 5, pp.196~201 (2000)
  6. "Predictors of failure of Helicobacter pylori eradication and predictors of ulcer recurrence:a randomized controlled trial", 22, pp.185~94 (1999)
  7. "Secondary resistance among 554 isolates of Helicobacter pylori after failure of therapy", pp.538~41, Eur J Clin Microbiol Infect Dis
  8. "Implications of antibiotic resistance in the management of Helicobacter pylori infection", 14, pp.862~8 (2000)
  9. "Predictors of failure of Helicobacter pylori eradication with the standard 'Maastricht triple therapy'", 15, pp.1023~9 (2001)
  10. "Reginal differences in metronidazole resistance and increasing clarithromycin resistance among Helicobacter pylori isolates from Japan", 44, pp.2214~6 (2000)
  11. "Prevalence of Helicobacter pylori resistance to metronidazole tetracycline and trovafloxacin in the Netherlands", pp.511~5
  12. "Prevalence of Helicobacter pylori resistance to several antimicrobial agents in a region of Germany", 17, pp.519~21 (1998)
  13. "European multicentre survey of in vitro antimicrobial resistance in Helicobacter pylori", 20, pp.820~3 (2001)
  14. "Antibiotic resistance of Helicobacter pylori isolated from Korea patients in 2003", 44, pp.126~35 (2004)
  15. "Current status and treatment of Helicobacter pylori infection in Korea", pp.39~
  16. "Changing pattern of antimicrobial resistance of Helicobacter pylori in Korean patients with peptic ulcer disease", 38, pp.436~441 (2003)
  17. "Association between mutation of rdxA gene and metronidazole resistance in Helicobacter pylori isolates from Korea", 7, pp.77~83 (2004)
  18. "Analysis of metronidazole,clarithromycin,and tetracycline resistance of Helicobacter pylori isolates from Korea", 47, pp.459~61 (2001)
  19. "Antimicrobial susceptibility testing of Helicobacter pylori in a large multicenter trial:the MACH 2 study", 43, pp.2747~52 (1999)
  20. "Clinical characteristics of patients with failed eradication of Helicobacter pylori and antibiotic resistance", 33, pp.311~20 (1999)
  21. "Choosing the best anti-Helicobacter pylori therapy:effect of antimicrobial resistance", 91, pp.1072~6 (1996)

이 간행물의 다른 논문 (14건)

다제내성의 확산에 있어서 integron의 역할장숙진pp. 1-9심근경색과 Chlamydophila pneumoniae 감염의 관련성채성철, 이원길, 허운보, 은상진, 이난영, 김유경pp. 10-16Ambler Class A Extended-Spectrum β-Lactamase 생성 Escherichia coli와 Klebsiella pneumoniae의국내분리현황어영, 김의종, 신종희, 용동은, 이위교, 강정옥, 배일권, 우건조, 권수봉, 강지혜, 박연준, 이종욱, 이경원, 안지영, 홍성근, 정석훈pp. 17-25Imipenem 내성 Pseudomonas aeruginosa의 분리 현황과 내성 획득 기전이보영, 정태전, 권수봉, 윤외숙, 배일권, 정연욱, 정석훈pp. 26-33Pulsed-field gel electrophoresis를 이용한 중환자실 Serratia marcescens 집단요로감염의 역학적 조사배인규, 김선주, 고은하pp. 34-40
원문 보기