Risk Factors Associated with Recurrent Urinary Tract Infection Caused by Escherichia coli
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Background: The purpose of this study was to analyze the clinical and microbiological characteristics of recurrent urinary tract infection (UTI) caused by Escherichia coli— the most common etiological agent. Methods: Cases of recurrent and single episodes of UTI caused by E. coli were evaluated retrospectively for a period of 6 months (January-June 2019) to analyze the clinical and molecular characteristics of this disease. Results: Healthcare-associated UTI, E. coli bacteremia, and poor microbial clearance 7 days post infection were associated more with the recurrent episodes of infection. E. coli isolates from subjects with recurrent UTIs showed higher rates of antimicrobial resistance and extended-spectrum β-lactamase (ESBL) production. The E. coli clone— sequence type 131 was detected in similar proportions in isolates, recovered from subjects in both groups— recurrent episodes and single episode of UTI. Conclusion: The control of antimicrobial-resistant ESBL-producing E. coli strains may be difficult using antimicrobial therapy and subsequently delay the clearance of the etiologic agent. This could play a major role in the development of recurrent UTIs.
Abstract
Background: The purpose of this study was to analyze the clinical and microbiological characteristics of recurrent urinary tract infection (UTI) caused by Escherichia coli— the most common etiological agent. Methods: Cases of recurrent and single episodes of UTI caused by E. coli were evaluated retrospectively for a period of 6 months (January-June 2019) to analyze the clinical and molecular characteristics of this disease. Results: Healthcare-associated UTI, E. coli bacteremia, and poor microbial clearance 7 days post infection were associated more with the recurrent episodes of infection. E. coli isolates from subjects with recurrent UTIs showed higher rates of antimicrobial resistance and extended-spectrum β-lactamase (ESBL) production. The E. coli clone— sequence type 131 was detected in similar proportions in isolates, recovered from subjects in both groups— recurrent episodes and single episode of UTI. Conclusion: The control of antimicrobial-resistant ESBL-producing E. coli strains may be difficult using antimicrobial therapy and subsequently delay the clearance of the etiologic agent. This could play a major role in the development of recurrent UTIs.
참고문헌 (16)
- Laupland KB, "Community-onset urinary tract infections : a population-based assessment", Infection, 35, pp.150~153 (2007)
- Jhang JF, "Recent advances in recurrent urinary tract infection from pathogenesis and biomarkers to prevention", Tzu Chi Med J, 29, pp.131~137 (2017)
- Foxman B, "Risk factors for second urinary tract infection among college women", Am J Epidemiol, 151, pp.1194~1205 (2000)
- Lee H, "Antimicrobial resistance of major clinical pathogens in South Korea, May 2016 to April 2017; first one-year report from KorGLASS", Euro Surveill, pp.23~ (2018)
- Robbins JR, "Impact of age-adjusted Charlson comorbidity score on outcomes for patients with early-stage endometrial cancer", Gynecol Oncol, 131, pp.593~597 (2013)
- Kim H, "Risk factors and molecular features of sequence type(ST)131 extended-spectrum β-lactamase-producing Escherichia coli in community-onset bacteremia", Sci Rep, 7, pp.14640~ (2017)
- Performance standards for antimicrobial susceptibility testing; 25th informational supplement, "Clinical and Laboratory Standards Institute (CLSI)", ~ (2015)
- Nordmann P, "Global spread of carbapenemase-producing Enterobacteriaceae", Emerg Infect Dis, 17, pp.1791~ (2011)
- 강철인, "Clinical Practice Guidelines for the Antibiotic Treatment of Community-Acquired Urinary Tract Infections", Infection and Chemotherapy, 50(1), pp.67~100 (2018), 대한감염학회
- Kim YA, "Community-onset extended-spectrum-β-lactamaseproducing Escherichia coli sequence type 131 at two Korean community hospitals: the spread of multidrug-resistant E. coli to the community via healthcare facilities", Int J Infect Dis, 54, pp.39~42 (2017)
- Kim S, "Prevalence and characteristics of Escherichia coli sequence type 131 and its H30 and H30Rx subclones : a multicenter study from Korea", Diagn Microbiol Infect Dis, 84, pp.97~101 (2016)
- Rogers BA, "Escherichia coli O25b-ST131: a pandemic, multiresistant, community-associated strain", J Antimicrob Chemother, 66, pp.1~14 (2011)
- Medina M, "An introduction to the epidemiology and burden of urinary tract infections", Ther Adv Urol, 11, pp.3~7 (2019)
- Jhang JF, "Recent advances in recurrent urinary tract infection from pathogenesis and biomarkers to prevention", Tzu Chi Med J, 29, pp.131~137 (2017)
- Ejrnæs K., "Bacterial characteristics of importance for recurrent urinary tract infections caused by Escherichia", Dan Med Bull, 58, pp.B4187~ (2011)
- Rosen DA, "Detection of intracellular bacterial communities in human urinary tract infection", PLoS Med, 4, pp.e329~ (2007)