Evaluation of Seroprevalence of SARS-CoV-2 IgG in Healthcare Workers in a Tertiary Hospital in Seoul
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Healthcare workers (HCWs) may be at high risk for exposure to the severe acute respiratorysyndrome coronavirus 2 (SARS-CoV-2) because of their frequent contact with patients or thedirect handling of respiratory samples. We investigated the seroprevalence of SARS-CoV-2IgG in HCWs in Seoul compared to those in coronavirus disease (COVID-19) patients andcommunity-based individuals to evaluate the antibody response. A total of 358 samples from348 individuals (155 HCWs, 7 COVID-19 patients, and 186 community-based individuals) werecollected from April to November 2020. SARS-CoV-2 IgG was detected in 1 of 155 HCWs (1of 46 HCWs with direct contact), 7 of 7 COVID-19 patients, and none of the 186 community based individuals (95% CI: 0.6%, 0.1 - 3.6%; 100%, 64.5 - 100%; 0.0%, 0.0 - 2.0%, respectively). The single HCW with a positive result showed 2.32 signal-to-cutoff (S/C) and 2.31 S/C at a3-week interval. Therefore, it was assumed to be a false positive due to autoantibody ormedication. The positive samples from 7 patients had a median of 3.79 S/C (range 1.72 - 6.54). The seroprevalence of SARS-CoV-2 IgG in HCWs was very low. The current infection controlstandard seems to be effective in protecting HCWs from COVID-19.
Abstract
Healthcare workers (HCWs) may be at high risk for exposure to the severe acute respiratorysyndrome coronavirus 2 (SARS-CoV-2) because of their frequent contact with patients or thedirect handling of respiratory samples. We investigated the seroprevalence of SARS-CoV-2IgG in HCWs in Seoul compared to those in coronavirus disease (COVID-19) patients andcommunity-based individuals to evaluate the antibody response. A total of 358 samples from348 individuals (155 HCWs, 7 COVID-19 patients, and 186 community-based individuals) werecollected from April to November 2020. SARS-CoV-2 IgG was detected in 1 of 155 HCWs (1of 46 HCWs with direct contact), 7 of 7 COVID-19 patients, and none of the 186 community based individuals (95% CI: 0.6%, 0.1 - 3.6%; 100%, 64.5 - 100%; 0.0%, 0.0 - 2.0%, respectively). The single HCW with a positive result showed 2.32 signal-to-cutoff (S/C) and 2.31 S/C at a3-week interval. Therefore, it was assumed to be a false positive due to autoantibody ormedication. The positive samples from 7 patients had a median of 3.79 S/C (range 1.72 - 6.54). The seroprevalence of SARS-CoV-2 IgG in HCWs was very low. The current infection controlstandard seems to be effective in protecting HCWs from COVID-19.
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