SARS-CoV-2 신속항원검사의 과제
Challenges of Scaling Up SARS-CoV-2 Rapid Antigen Tests
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초록
코로나바이러스감염증-19 (coronavirus disease 2019, COVID-19)에 대한 표준 검사법은 제2형 중증급성호흡기증후군 코로나바이러스(severe acute respiratory syndrome coronavirus 2, SARS-CoV-2)의 분자 검사이다. SARS-CoV-2 신속항원검사는 비록 진단적 민감도는 분자진단법에 비하여 낮지만 신속하고 경제적이고 간편한 검사이다. 그러나 신속항원검사의 위음성 가능성을 고려하여 분자검사와 함께 사용하여야 하며 적절한 검사 알고리즘을 개발하는 것이 필요하다.
Abstract
The current reference standard for the diagnosis of coronavirus disease 2019 (COVID-19) is themolecular detection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Severalrapid antigen tests (RATs) have been developed for the rapid and inexpensive detection ofSARS-CoV-2, which can be used at the point-of-care. Although RATs have lower SARS-CoV-2detection sensitivity than molecular tests, the development of a more cost-effective highthroughputtest system that offers a rapid turnaround time is vital for curtailing the spreadof SARS-CoV-2. However, because of the growing concern over the substantial risk of falsenegative results, RATs should be used in conjunction with molecular tests and therefore, anappropriate test algorithm should be developed to achieve this purpose.
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