Group B Streptococcus Vaccines: Progress and Potential
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Group B Streptococcus (GBS, Streptococcus agalactiae) is a pathogen that causes sepsis and meningitis, particularly in newborns, as well as severe infections in the elderly and those at high risk. For many years, the administration of intrapartum antimicrobial prophylaxis (IAP) has been a standard method to prevent neonatal GBS infection. However, IAP may be unsuitable in low-income settings due to its high cost and difficult accessibility to medical institutions. Additionally, IAP may lead to the emergence of antimicrobial-resistant bacteria. Hence, an alternative method for the control of GBS, such as a vaccine, is needed. An effective vaccine will likely prevent the further spread of GBS and be cost-effective compared with IAP. GBS vaccines have been under development for the past two decades, and several candidates have shown potential. In this review, we discuss the current development of GBS vaccines, including types and their implementation in different target populations.
Abstract
Group B Streptococcus (GBS, Streptococcus agalactiae) is a pathogen that causes sepsis and meningitis, particularly in newborns, as well as severe infections in the elderly and those at high risk. For many years, the administration of intrapartum antimicrobial prophylaxis (IAP) has been a standard method to prevent neonatal GBS infection. However, IAP may be unsuitable in low-income settings due to its high cost and difficult accessibility to medical institutions. Additionally, IAP may lead to the emergence of antimicrobial-resistant bacteria. Hence, an alternative method for the control of GBS, such as a vaccine, is needed. An effective vaccine will likely prevent the further spread of GBS and be cost-effective compared with IAP. GBS vaccines have been under development for the past two decades, and several candidates have shown potential. In this review, we discuss the current development of GBS vaccines, including types and their implementation in different target populations.
참고문헌 (48)
- Kong F, "Serotype identification of group B streptococci by PCR and sequencing", J Clin Microbiol, 40, pp.216~226 (2002)
- Hanna M, "StatPearls" (2020), StatPearls Publishing
- Russell NJ, "Maternal colonization with group B Streptococcus and serotype distribution worldwide : systematic review and meta-analyses", Clin Infect Dis, 65, pp.S100~S111 (2017)
- Blencowe H, "National, regional, and worldwide estimates of stillbirth rates in 2015, with trends from 2000 : a systematic analysis", Lancet Glob Health, 4, pp.e98~e108 (2016)
- Lawn JE, "Every newborn: progress, priorities, and potential beyond survival", Lancet, 384, pp.189~205 (2014)
- Liu L, "Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis", Lancet, 385, pp.430~440 (2015)
- Seale AC, "Estimates of the burden of group B streptococcal disease worldwide for pregnant women, stillbirths, and children", Clin Infect Dis, 65, pp.S200~S219 (2017)
- "Group B Strep (GBS)"[URL]
- Braye K, "Group B streptococcal screening, intrapartum antibiotic prophylaxis, and neonatal early-onset infection rates in an Australian local health district : 2006-2016", PLoS One, 14, pp.e0214295~ (2019)
- Horsley L, "CDC updates guidelines for the prevention of perinatal GBS disease", Am Fam Physician, 83, pp.1106~1110 (2011)
- Fairlie T, "Effectiveness of intrapartum antibiotic prophylaxis for prevention of early-onset group B streptococcal disease", Obstet Gynecol, 121, pp.570~577 (2013)
- Pintye J, "Risk factors for late-onset group B streptococcal disease before and after implementation of universal screening and intrapartum antibiotic prophylaxis", J Pediatric Infect Dis Soc, 5, pp.431~438 (2016)
- Carreras-Abad C, "A vaccine against group B Streptococcus : recent advances", Infect Drug Resist, pp.1263~1272 (2020)
- Nogacka A, "Impact of intrapartum antimicrobial prophylaxis upon the intestinal microbiota and the prevalence of antibiotic resistance genes in vaginally delivered full-term neonates", Microbiome, 5, pp.1~10 (2017)
- Azad MB, "Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study", BJOG: Int J Obstet Gynaecol, 123, pp.983~993 (2016)
- Corvaglia L, "Influence of intrapartum antibiotic prophylaxis for group B Streptococcus on gut microbiota in the first month of life", J Pediatr Gastroenterol Nutr, 62, pp.304~308 (2016)
- "Serotypes and the importance of serotyping Salmonella"[URL]
- Madrid L, "Infant group B streptococcal disease incidence and serotypes worldwide : systematic review and metaanalyses", Clin Infect Dis, 65, pp.S160~S172 (2017)
- Kang HM, "Genotype characterization of group B Streptococcus isolated from infants with invasive diseases in South Korea", Pediatr Infect Dis J, 36, pp.e242~e247 (2017)
- Yao Z, "Identification of group B Streptococcus serotypes and genotypes in late pregnant women and neonates that are associated with neonatal early-onset infection in a South China population", Front Pediatr, 8, pp.265~ (2020)
- Hannoun A, "Correlation between group B streptococcal genotypes, their antimicrobial resistance profiles, and virulence genes among pregnant women in Lebanon", Int J Microbiol, 2009 (2009)
- Takashi Takahashi, "Clonal Distribution of Clindamycin-Resistant Erythromycin-Susceptible (CRES) <italic>Streptococcus agalactiae<", italic> in Korea Based on Whole Genome Sequences, 2020, pp.40(5), 370~381[DOI]
- Udo EE, "Genotypes and virulence genes in group B Streptococcus isolated in the maternity hospital, Kuwait", Med Princ Pract, 22, pp.453~457 (2013)
- Zakerifar M, "Antibiotic resistance genes and molecular typing of Streptococcus agalactiae isolated from pregnant women", BMC Pregnancy Childbirth, 23, pp.1~13 (2023)
- Berner R, "Group B Streptococcus vaccines: one step further", Lancet Infect Dis, 21, pp.158~160 (2021)
- "Routine vaccines, extraordinary impact: Group B Streptococcus (GBS)"[URL]
- Baker CJ, "Correlation of maternal antibody deficiency with susceptibility to neonatal group B streptococcal infection", N Engl J Med, 294, pp.753~756 (1976)
- Lin FYC, "Level of maternal antibody required to protect neonates against early-onset disease caused by group B Streptococcus type Ia: a multicenter, seroepidemiology study", J Infect Dis, 184, pp.1022~1028 (2001)
- Baker CJ, "Maternal antibody at delivery protects neonates from early-onset group B streptococcal disease", J Infect Dis, 209, pp.781~788 (2014)
- Johri AK, "Group B Streptococcus : global incidence and vaccine development", Nat Rev Microbiol, 4, pp.932~942 (2006)
- Paoletti LC, "Conjugate vaccines against group B Streptococcus types IV and VII", J Infect Dis, 186, pp.123~126 (2002)
- Wessels M, "Immunogenicity in animals of a polysaccharide-protein conjugate vaccine against type III group B Streptococcus", J Clin Invest, 86, pp.1428~1433 (1990)
- Kasper DL, "Immune response to type III group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine", J Clin Invest, 98, pp.2308~2314 (1996)
- Baker CJ, "Safety and immunogenicity of a bivalent group B streptococcal conjugate vaccine for serotypes II and III", J Infect Dis, 188, pp.66~73 (2003)
- Ali MM, "Group B Streptococcus colonization rate and serotype distribution among pregnant women and their newborns at Adama Hospital Medical College", Ethiopia. Sci Rep, 10, pp.9301~ (2020)
- Baker C, "Group B streptococcal conjugate vaccines", Arch Dis Child, 88, pp.375~378 (2003)
- Dhar N, "Immune responses against group B Streptococcus monovalent and pentavalent capsular polysaccharide tetanus toxoid conjugate vaccines in Balb", c mice, 2023, pp.26, 107380~
- Dominguez K, "Toward the development of a protein-based group B Streptococcus vaccine", Cell Rep Med, 3, pp.100536~ (2022)
- Fischer P, "Safety and immunogenicity of a prototype recombinant alpha-like protein subunit vaccine(GBS-NN)against Group B Streptococcus in a randomized placebo-controlled double-blind phase 1 trial in healthy adult women", Vaccine, 39, pp.4489~4499 (2021)
- Pawlowski A, "A group B Streptococcus alpha-like protein subunit vaccine induces functionally active antibodies in humans targeting homotypic and heterotypic strains", Cell Rep Med, 3, pp.100511~ (2022)
- "Group B streptococcal infections: the Division of Bacterial and Mycotic Diseases National Center for Infectious Diseases Centers for Disease Control and Prevention"[URL]
- "MinervaX commences first phase 1 clinical study of novel GBS vaccine in older adults"[URL]
- McLaughlin JM, "The burden of adults hospitalized with group B streptococcal infection", J Infect Dis, 224, pp.1170~1178 (2021)
- "Active bacterial core surveillance report, emerging infections program network, group B Streptococcus" (2009)[URL]
- Smith E, "Group B Streptococcus infections of soft tissue and bone in California adults, 1995–2012", Epidemiol Infect, 143, pp.3343~3350 (2015)
- Lamagni TL, "Emerging trends in the epidemiology of invasive group B streptococcal disease in England and Wales, 1991–2010", Clin Infect Dis, 57, pp.682~688 (2013)
- Palazzi DL, "Use of type V group B streptococcal conjugate vaccine in adults 65–85 years old", J Infect Dis, 190, pp.558~564 (2004)
- "MinervaX initiates Phase I GBS vaccine trial in older people"[URL]
