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Clinical manifestations, diagnosis, and antimicrobial resistance of group A streptococci infections

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초록

Group A streptococci (GAS) cause diverse diseases ranging from mild to severe illnesses,and the global burden of GAS infections is enormous. Serological typing has been replacedby emm genotyping for the epidemiological study of GAS. Acute bacterial pharyngitis is acommon illness, which requires either throat culture or rapid Ag test for diagnosis. Moreover,molecular point-of-care tests have been introduced owing to their higher sensitivity. Optimaldiagnosis of bacterial pharyngitis is necessary for the adequate use of antibiotics. Althoughantimicrobial resistance (AMR) to erythromycin or clindamycin does not seem serious inKorea, it is very high in China, being reported at over 90%. Antibiotic surveillance and relevanteducation are necessary for primary clinical physicians and pediatricians. It is necessary tomonitor AMR and develop a system for reporting the appearance of highly virulent diseases,such as necrotizing fasciitis or streptococcal toxic-shock syndrome, to the governmentauthority.

Abstract

Group A streptococci (GAS) cause diverse diseases ranging from mild to severe illnesses,and the global burden of GAS infections is enormous. Serological typing has been replacedby emm genotyping for the epidemiological study of GAS. Acute bacterial pharyngitis is acommon illness, which requires either throat culture or rapid Ag test for diagnosis. Moreover,molecular point-of-care tests have been introduced owing to their higher sensitivity. Optimaldiagnosis of bacterial pharyngitis is necessary for the adequate use of antibiotics. Althoughantimicrobial resistance (AMR) to erythromycin or clindamycin does not seem serious inKorea, it is very high in China, being reported at over 90%. Antibiotic surveillance and relevanteducation are necessary for primary clinical physicians and pediatricians. It is necessary tomonitor AMR and develop a system for reporting the appearance of highly virulent diseases,such as necrotizing fasciitis or streptococcal toxic-shock syndrome, to the governmentauthority.

참고문헌 (41)

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관련 논문AI추천

Epidemiology and Erythromycin Resistance of Streptococcus pyogenes in the Last 20 Years김선주대한임상미생물학회 · Annals of Clinical Microbiology2011 · 제14권 제4호Multicenter Study of Molecular Epidemiology and Antibiotic Resistance of Group A Streptococci in 2008-2009 in Korea강정옥, 고은하, 김선주, 김영리, 김의종, 김재석, 신정환, 이남용, 장철훈, 정윤성, 조지현대한임상미생물학회 · Annals of Clinical Microbiology2011 · 제14권 제3호emm Types and Clusters of Group A Streptococcus Causing Acute Pharyngitis in Changwon Korea, 2018–2019김선주, 이승준, 조선아대한임상미생물학회 · Annals of Clinical Microbiology2021 · 제24권 제4호Decline in Erythromycin Resistance in Group A Streptococci from Acute Pharyngitis due to Changes in the emm Genotypes Rather Than Restriction of Antibiotic Use고은하, 김선주대한진단검사의학회 · Annals of Laboratory Medicine2010 · 제30권 제5호Epidemiological Study of Erythromycin-Resistant Streptococcus pyogenes From Korea and Japan by emm Genotyping and Multilocus Sequence Typing고은하, 김선주, 이동현, Haruno Yoshida, Hisakazu Yano, Kazuaki Arai, Mitsuo Kaku, Takashi Takahashi대한진단검사의학회 · Annals of Laboratory Medicine2016 · 제36권 제1호Current and Continuing Controversies Associated with the Diagnosis and Management of Group A Streptococcal InfectionsEdward L. Kaplan대한소아감염학회 · Pediatric Infection and Vaccine2003 · 제10권 제2호

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