삽살개의 연령에 따른 혈구 및 혈청 생화학 수치 변화 양상 연구
Changes in the complete blood count and serum biochemical parameters of Sapsaree dogs according to different age groups
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The complete blood count and serum biochemical parameters are essential tools for diagnosis and mon-itoring of physiological and disease conditions in dogs. These parameters may be affected by the breed and age of dogs. This study aimed to compare the changes of complete blood count and serum biochemical parameters according to the increasing age in 156 Sapsarees. In this study, the Sapsarees were clustered into ten age groups: four to six months, seven to nine months, ten to twelve months, one year, two years, three to four years, five to six years, seven to eight years, nine to ten years, and, eleven to twelve years old. In the result of the complete blood count, the total red blood cell count (P＜0.001), hematocrit (P＜ 0.001), and hemoglobin (P＜0.001) values were significantly increased from 4∼6 months to 2 years old Sapsarees. While the mean corpuscular volume (P＜0.001) and mean corpuscular hemoglobin (P＜ 0.001) values were significantly increased from 4∼6 months to 3∼4 years old. The mean corpuscular hemoglobin concentration was significantly (P=0.037) increased from 4∼6 to 10∼12-month-old Sap-sarees. Total white cell count was significantly (P＜0.001) decreased from 1 year to 9∼10 years old. The result of differential white blood cell count showed that neutrophil count was significantly (P＜ 0.001) increased from the age 4∼6 months to 11∼12 years old Sapsarees, whereas, lymphocyte (P＜ 0.001), monocyte (P＜0.001), and eosinophil (P=0.042) counts were significantly decreased from 7∼9 months to 7∼8 years, 4∼6 months to 9∼10 years, 3∼4 to 5∼6 years old, respectively. In the serum bio-chemistry result, the creatinine concentration was significantly (P＜0.001) increased from 4∼6 to 10∼12 months, but significantly (P=0.006) decreased from 7∼8 to 10∼12 years old. Phosphate concentration was significantly (P＜0.001) decreased from 3∼4 to 9∼10 years old, but significantly (P=0.021) increased from 9∼10 to 11∼12 years old. Calcium concentration significantly (P＜0.001) decreased from 10∼12 months to 11∼12 years old. Total protein concentration significantly (P＜0.001) increased from 4∼6 months to 2 years old. While concentrations of albumin (P=0.004) and globulin (P＜0.001) was signifi-cantly increased from 4∼6 months to 3∼4 years old, and from 4∼6 months to 11∼12 years old, respect-ively. The alkaline phosphate concentration was significantly (P＜0.001) decreased from 4∼6 months to 2 years old. We found that there are differences in the hematological parameters in relation with the increasing age in Sapsaree breed.
Abstract
The complete blood count and serum biochemical parameters are essential tools for diagnosis and mon-itoring of physiological and disease conditions in dogs. These parameters may be affected by the breed and age of dogs. This study aimed to compare the changes of complete blood count and serum biochemical parameters according to the increasing age in 156 Sapsarees. In this study, the Sapsarees were clustered into ten age groups: four to six months, seven to nine months, ten to twelve months, one year, two years, three to four years, five to six years, seven to eight years, nine to ten years, and, eleven to twelve years old. In the result of the complete blood count, the total red blood cell count (P＜0.001), hematocrit (P＜ 0.001), and hemoglobin (P＜0.001) values were significantly increased from 4∼6 months to 2 years old Sapsarees. While the mean corpuscular volume (P＜0.001) and mean corpuscular hemoglobin (P＜ 0.001) values were significantly increased from 4∼6 months to 3∼4 years old. The mean corpuscular hemoglobin concentration was significantly (P=0.037) increased from 4∼6 to 10∼12-month-old Sap-sarees. Total white cell count was significantly (P＜0.001) decreased from 1 year to 9∼10 years old. The result of differential white blood cell count showed that neutrophil count was significantly (P＜ 0.001) increased from the age 4∼6 months to 11∼12 years old Sapsarees, whereas, lymphocyte (P＜ 0.001), monocyte (P＜0.001), and eosinophil (P=0.042) counts were significantly decreased from 7∼9 months to 7∼8 years, 4∼6 months to 9∼10 years, 3∼4 to 5∼6 years old, respectively. In the serum bio-chemistry result, the creatinine concentration was significantly (P＜0.001) increased from 4∼6 to 10∼12 months, but significantly (P=0.006) decreased from 7∼8 to 10∼12 years old. Phosphate concentration was significantly (P＜0.001) decreased from 3∼4 to 9∼10 years old, but significantly (P=0.021) increased from 9∼10 to 11∼12 years old. Calcium concentration significantly (P＜0.001) decreased from 10∼12 months to 11∼12 years old. Total protein concentration significantly (P＜0.001) increased from 4∼6 months to 2 years old. While concentrations of albumin (P=0.004) and globulin (P＜0.001) was signifi-cantly increased from 4∼6 months to 3∼4 years old, and from 4∼6 months to 11∼12 years old, respect-ively. The alkaline phosphate concentration was significantly (P＜0.001) decreased from 4∼6 months to 2 years old. We found that there are differences in the hematological parameters in relation with the increasing age in Sapsaree breed.
참고문헌 (31)
- Brenten T, "Age-associated and breed-associated variations in haematological and biochemical variables in young labrador retriever and miniature schnauzer dogs", Vet Rec Open, 3, pp.e000166~ (2016)
- Bush BM., "Interpretation of laboratory results for small animal clinicians" (1991), Blackwell Scientific Publication
- Chang YM, "Serum biochemical phenotypes in the domestic dog", PloS one, 11, pp.e0149650~ (2016)
- So-Young Choi, "Basic data on the hematology, serum biochemistry, urology, and organ weights of beagle dogs", Laboratory Animal Research, 27(4), pp.283~291 (2011), 한국실험동물학회
- Crincoli CM, "A 90-day dietary study of a(2R, 4R)-monatin salt in Beagle dogs", Food Chem Toxicol, 91, pp.181~190 (2016)
- De Martinis M, "Inflammageing and lifelong antigenic load as major determinants of ageing rate and longevity", FEBS Lett, 579, pp.2035~2039 (2005)
- Dircks BH, "Platelet-neutrophil aggregate formation in blood samples from dogs with systemic inflammatory disorders", Am J Vet Res, 73, pp.939~945 (2012)
- Goddard A, "Platelet activation and platelet–leukocyte interaction in dogs naturally infected with Babesia rossi", Vet J, 205, pp.387~392 (2015)
- Harper EJ, "Age-related variations in hematologic and plasma biochemical test results in Beagles and Labrador Retrievers", J Am Vet Med Assoc, 223, pp.1436~1442 (2003)
- Hawkey CM, "Comparative Mammalian Haematology", pp.3~15 (1975), Whitefriars Press Ltd
- Ikeuchi J, "Plasma biochemistry values of young beagle dogs", J Toxicol Sci, 16, pp.49~59 (1991)
- Kaneko JJ, "Clinical Biochemistry of Domestic Animals", pp.889~896 (2008), Academic Press
- Kaspar LV, "Serum chemistry values of normal dogs(beagles) : associations with age, sex, and family line", Lab Anim Sci, 27, pp.980~985 (1997)
- 김은주, "국내 반려견의 품종에 따른 혈구 및 생화학 수치 비교 연구", 한국동물위생학회지, 41(1), pp.1~8 (2018), 한국동물위생학회
- Lequarre AS, "LUPA : a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs", Vet J, 189, pp.155~159 (2011)
- Levy JK, "Effect of age on reference intervals of serum biochemical values in kittens", J Am Vet Med Assoc, 228, pp.1033~1037 (2006)
- Lowseth LA, "The effects of aging on hematology and serum chemistry values in the beagle dog", Vet Clin Pathol, 19, pp.13~19 (1990)
- Lund C, "Reference values of the red blood profile in beagle, German shepherd and golden retriever puppies", Berl Munch Tierarztl, 113, pp.447~453 (2000)
- Meuten D, "Veterinary hematology and clinical chemistry", pp.545~568 (2012), Wiley-Blackwell
- Moritz A, "Evaluation of flow cytometric and automated methods for detection of activated platelets in dogs with inflammatory disease", Am J Vet Res, 66, pp.325~329 (2005)
- Mundim AV, "Influence of age and sex on the serum biochemical profile of Doberman dogs in the growth phase", Comp Clin Path, 16, pp.41~46 (2007)
- Oo T, "Age Related Changes in Hematological Values of Myanmar Local Puppies", J Adv Vet Anim Res, 7, pp.116~119 (2017)
- 박창은, "경주지방의 경주개 동경이(무미 또는 단미 형태의 개) 에서 혈액상 분석에 대한 실태조사", 한국동물위생학회지, 33(4), pp.367~373 (2010), 한국동물위생학회
- Pickrell JA, "Relationship of age of normal dogs to blood serum constituents and reliability of measured single values", Am J Vet Res, 35, pp.897~903 (1974)
- Rørtveit R, "Age‐related changes in hematologic and serum biochemical variables in dogs aged 16-60 days", Vet Clin Pathol, 44, pp.47~57 (2015)
- Rosol TJ, "Clinical biochemistry of domestic animals", pp.646~648 (1997), Academic Press
- Rosset E, "Age‐related changes in biochemical and hematologic variables in Borzoi and Beagle puppies from birth to 8 weeks", Vet Clin Pathol, 41, pp.272~282 (2012)
- Smets PM, "Renal function and morphology in aged Beagle dogs before and after hydrocortisone administration", PLoS One, 7, pp.e31702~ (2012)
- Weiner DJ, "The hemogram and certain serum protein fractions in normal beagle dogs", Veterinary Medicine Small Animal Clinician, 67, pp.393~398 (1972)
- Weiss DJ, "Detection of activated platelets in dogs with primary immune‐mediated hemolytic anemia", J Vet Intern Med, 20, pp.682~686 (2006)
- Youn SK, "Studies on hematologic values and serum chemistry of Jindo, Poongsan and Mixed dogs", J Vet Clin, 16, pp.248~252 (1999)