HPLC/MS을 이용한 aminoglycoside 항생제 동시 분석에 관한 연구
Simultaneous determination of aminoglycoside antibiotics by HPLC/MS
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Abstract
A liquid chromatographic method has been developed for the analysis of aminoglycoside antibiotics(AMGs) using Heptafluorobutyric acid(HFBA) as a ion-pairing reagent. AMGs(amikacin, apramycin, dihydrostreptomycin, gentamicin, hygrosin B, kanamycin, neomycin, spectinomycin and tobramycin) were formed by reaction with HFBA as ion-pairing reagent. HFBA was attached to corresponding amino group of AMGs. These AMGs compounds were separated and detected by electrospray ionization mass spectrometry(ESI-MS). The experimental conditions for separation of AMGs were optimized and validated. A simple liquid chromatographic method for the determination of AMGs was demonstrated.
참고문헌 (17)
- "et al. 1990. Extraction methods for quantitation of gentamicin residues from tissues using fluorescence polarization immunoassay. J Assoc Off Anal Chem 73", pp.479~483
- coside antibiotics using pre-column derivation with phenyisocyanate, , 2003, 396~403
- mycin by liquid chromatography, , 2001, 59~66
- "Determination of gentamicins C1, C1a and C2 in plasma and urine by HPLC", 46, pp.837~842 (2000)
- "Jackson J. 1992. Improved liquid chromatograhic determination of neomycin B in bovine kidney. J AOAC Int 76", pp.543~548
- nation of neamine neomycin B and neomycin C in neomycin sulfate. J Chromatogr 235, , 215~220
- , 445~457
- , 2275~2278
- mination of neomycin in animal tissues by liquid chromatography, , 1999, 61~67
- phy with evaporative light scattering detection, , 2004, 281~287
- "Development and validation of a novel LC", ELSD method for the quantitation of gentamicin sulfate components in pharmaceuticals, 2004, pp.36(1), 73~79
- , 521~523
- "Chromatographic method of analysis of antibiotics in milk", 812, pp.99~109 (1998)
- "Vestal ML. 1991. Analysis of gentamycin sulfate by high-performance liquid chromatography combine with thermospray mass spectrometry. J Chromatogr 554"
- sides by HPLC-MS, "MS", pp.1~18 (2003), United State Department of Agriculture Food Safety Inspection Service, Office of Public Health and Science
- metry to determine six AMGs in serum, , 2004, 197~201
- "식품의 기준 및 규격", (2005-27), pp.59~69 (2005), 식품의약품안정청