Phenobarbital and zonisamide treatment of a cat with epilepsy of unknown cause
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A Korean domestic short hair (1-year-old, male) presented with 2 to 3 weeks of seizures, aggressive behavior, vomiting, anorexia, and lethargy. The frequency of seizure had gradually increased from once a week to once every 3 hours. Physical and neurologic examination, diagnostic screening tests, including complete blood count (CBC), serum chemistry, electrolyte, coagulation test, X-ray, ultrasonography, and urinalysis were performed. Feline Leukemia Virus (FeLV), Feline Immunodeficiency Virus (FIV) and Toxoplasma spp. All tested negative, but the Feline Corona Virus (FCoV) kit revealed a positive result. To determine the exact diagnosis, magnetic resonance imaging (MRI) was performed but yielded no specific findings. The patient was then diagnosed with idiopathic epilepsy and treatment of phenobarbital was initiated. A month’s treatment with phenobarbital proved ineffective as symptoms worsened. Zonisamide was then selected as an additional anticonvulsant. After adding zonisamide, symptoms im-proved, and seizures abated for 15 months. This is the first case report in South Korea describing the use of phenobarbital and zonisamide in the treatment of a cat with idiopathic epilepsy.
Abstract
A Korean domestic short hair (1-year-old, male) presented with 2 to 3 weeks of seizures, aggressive behavior, vomiting, anorexia, and lethargy. The frequency of seizure had gradually increased from once a week to once every 3 hours. Physical and neurologic examination, diagnostic screening tests, including complete blood count (CBC), serum chemistry, electrolyte, coagulation test, X-ray, ultrasonography, and urinalysis were performed. Feline Leukemia Virus (FeLV), Feline Immunodeficiency Virus (FIV) and Toxoplasma spp. All tested negative, but the Feline Corona Virus (FCoV) kit revealed a positive result. To determine the exact diagnosis, magnetic resonance imaging (MRI) was performed but yielded no specific findings. The patient was then diagnosed with idiopathic epilepsy and treatment of phenobarbital was initiated. A month’s treatment with phenobarbital proved ineffective as symptoms worsened. Zonisamide was then selected as an additional anticonvulsant. After adding zonisamide, symptoms im-proved, and seizures abated for 15 months. This is the first case report in South Korea describing the use of phenobarbital and zonisamide in the treatment of a cat with idiopathic epilepsy.
참고문헌 (13)
- Bailey KS, "The Seizuring Cat Diagnostic Work-Up and Therapy", J Feline Med Surg, 11, pp.385~394 (2009)
- Berg AT, "Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005-2009", Epilepsia, 51, pp.676~685 (2010)
- Christopher LM, "Terminology and classification of seizures and epilepsy in veterinary patients", Top Companion Anim Med, 28, pp.34~41 (2013)
- Hasegawa D, "Pharmacokinetics and toxicity of zonisamide in cats", J Feline Med Surg, 10, pp.418~421 (2008)
- Kuwabara T, "A familial spontaneous epileptic feline strain: a novel model of idiopathic", genetic epilepsy, 2010, pp.92, 85~88
- Little SE, "The cat: clinical medicine and management", pp.1038~1047 (2012), Elsevier Health Sciences
- Muñana KR, "Management of refractory epilepsy", Top Companion Anim Med, 28, pp.67~71 (2013)
- Pákozdy A, "Clinical comparison of primary versus secondary epilepsy in 125 cats", J Feline Med Surg, 12, pp.910~916 (2010)
- Pakozdy A, "Treatment and long-term follow-up of cats with suspected primary epilepsy", J Feline Med Surg, 15, pp.267~273 (2013)
- Plumb DC, "Plumb’s veterinary drug handbook", pp.1143~1147 (2015), Wiley-Blackwell
- Rusbridge C, "Diagnosis and control of epilepsy in the cat", In Practice, 27, pp.208~214 (2005)
- Schriefl S, "Etiologic classification of seizures, signalment, clinical signs, and outcome in cats with seizure disorders: 91 cases (2000-2004)", J Am Vet Med Assoc, 233, pp.1591~1597 (2008)
- Wahle AM, "Clinical characterization of epilepsy of unknown cause in cats", J Vet Intern Med, 28, pp.182~188 (2014)