Assessment of radiographic left atrial dimension and C-reactive protein in dogs with myxomatous mitral valve disease
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Radiographic left atrial dimension (RLAD) is a valuable metric for assessing left atrial enlargement in dogs. While there have been studies on the use of RLAD and the increase in C-reactive protein (CRP) levels based on heart disease stages, there has been no prior research on the correlation between RLAD and CRP. In this study, the objective was to investigate the relationship between the rise in RLAD as myxomatous mitral valve disease (MMVD) stages advance and the increase in CRP levels with MMVD stage progression. In this study, a total of 30 small-breed dogs were included as subjects. These dogs were diagnosed with MMVD at the American College of Veterinary Internal Medicine (ACVIM) stage B1 or B2, or stage C, based on a comprehensive assessment including physical examination, thoracic radiography, and echocardiography. Measurements of VHS and RLAD were compared to assess any significant differences. There were significant differences in RLAD between dogs with MMVD ACVIM stage B1 and those with stage C. The monocytes and CRP levels showed significant differences between ACVIM stage B1, B2 and ACVIM C. Additionally, a significant correlation was observed between the RLAD and VHS measurements. This underscores the notable association between MMVD stage advancement and elevated monocyte and CRP levels. The RLAD scores exhibited a significant difference among dogs with ACVIM stages B1, B2, and C, and significant variations were also observed in monocyte and CRP levels. These results suggest that monocyte and CRP levels may be a valuable diagnostic indicator for heart disease in dogs during the diagnostic evaluation.
Abstract
Radiographic left atrial dimension (RLAD) is a valuable metric for assessing left atrial enlargement in dogs. While there have been studies on the use of RLAD and the increase in C-reactive protein (CRP) levels based on heart disease stages, there has been no prior research on the correlation between RLAD and CRP. In this study, the objective was to investigate the relationship between the rise in RLAD as myxomatous mitral valve disease (MMVD) stages advance and the increase in CRP levels with MMVD stage progression. In this study, a total of 30 small-breed dogs were included as subjects. These dogs were diagnosed with MMVD at the American College of Veterinary Internal Medicine (ACVIM) stage B1 or B2, or stage C, based on a comprehensive assessment including physical examination, thoracic radiography, and echocardiography. Measurements of VHS and RLAD were compared to assess any significant differences. There were significant differences in RLAD between dogs with MMVD ACVIM stage B1 and those with stage C. The monocytes and CRP levels showed significant differences between ACVIM stage B1, B2 and ACVIM C. Additionally, a significant correlation was observed between the RLAD and VHS measurements. This underscores the notable association between MMVD stage advancement and elevated monocyte and CRP levels. The RLAD scores exhibited a significant difference among dogs with ACVIM stages B1, B2, and C, and significant variations were also observed in monocyte and CRP levels. These results suggest that monocyte and CRP levels may be a valuable diagnostic indicator for heart disease in dogs during the diagnostic evaluation.
참고문헌 (13)
- Buchanan JW, "Vertebral scale system to measure heart size in radiographs", J Am Vet Med Assoc, 206, pp.194~199 (1995)
- Domanjko Petrič A, "Systemic inflammation in dogs with advanced-stage heart failure", Acta Vet Scand, 60, pp.20~ (2018)
- Ettinger SJ, "Textbook of veterinary internal medicine", pp.1252~1264, Elsevier
- Fox PR, "Pathology of myxomatous mitral valve disease in the dog", J Vet Cardiol, 14, pp.103~126 (2012)
- Hwang SH, "Assessment of vertebral left atrial size and C-reactive protein in dogs with myxomatous mitral valve disease", J Vet Clin, 38(1), pp.16~20 (2021)
- Keene BW, "ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs", J Vet Intern Med, 33, pp.1127~1140 (2019)
- Kittleson MD, "Regurgitant fraction measured by using the proximal isovelocity surface area method in dogs with chronic myxomatous mitral valve disease", J Vet Intern Med, 17, pp.84~88 (2003)
- Lam C, "Radiographic quantification of left atrial size in dogs with myxomatous mitral valve disease", J Vet Intern Med, 35, pp.747~754 (2021)
- Lee SI, "Assessment of radiographic left atrial dimension in Maltese dogs with ACVIM stage B myxomatous mitral valve disease", J Vet Clin, 39, pp.287~293 (2022)
- Malcolm EL, "Diagnostic value of vertebral left atrial size as determined from thoracic radiographs for assessment of left atrial size in dogs with myxomatous mitral valve disease", J Am Vet Med Assoc, 253, pp.1038~1045 (2018)
- Reimann MJ, "Increased serum C-reactive protein concentrations in dogs with congestive heart failure due to myxomatous mitral valve disease", Vet J, 209, pp.113~118 (2016)
- Sánchez Salguero X, "A radiographic measurement of left atrial size in dogs", Ir Vet J, 71, pp.25~ (2018)
- Vezzosi T, "Radiographic vertebral left atrial size : A reference interval study in healthy adult dogs", Vet Radiol Ultrasound, 61, pp.507~511 (2020)