Xylitol Sensitivity among Oral Streptococci
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Xylitol is a five-carbon sugar alcohol that inhibits thegrowth of oral streptococci, including Streptococcus mutans. In this study, we tested xylitol sensitivity among the oralstreptococci. We also compared nucleotide homology ofputative fructose phosphotransferase system (PTS) andxylitol sensitivity, since xylitol is transported via the fructosePTS. Among the tested Streptococci, S. pneumonia showedthe highest resistance to xylitol while S. gordonii and S. sanguinis showed the most sensitive growth inhibition. These streptococci could be grouped according to theirxylitol sensitivity. S. mutans and S. salivarius showed similarbacterial growth inhibition by xylitol. S. mitis, S. oralis, S. pneumonia, S. intermedius and S. anginosus showedrelatively low sensitivity to xylitol. When the genetichomologies of five fructose PTSs were compared among thetested streptococci, closely related streptococci showedsimilar sensitivity to xylitol. Taken together, fructose PTSsmay mediate the sensitivity to xylitol in oral streptococci.
Abstract
Xylitol is a five-carbon sugar alcohol that inhibits thegrowth of oral streptococci, including Streptococcus mutans. In this study, we tested xylitol sensitivity among the oralstreptococci. We also compared nucleotide homology ofputative fructose phosphotransferase system (PTS) andxylitol sensitivity, since xylitol is transported via the fructosePTS. Among the tested Streptococci, S. pneumonia showedthe highest resistance to xylitol while S. gordonii and S. sanguinis showed the most sensitive growth inhibition. These streptococci could be grouped according to theirxylitol sensitivity. S. mutans and S. salivarius showed similarbacterial growth inhibition by xylitol. S. mitis, S. oralis, S. pneumonia, S. intermedius and S. anginosus showedrelatively low sensitivity to xylitol. When the genetichomologies of five fructose PTSs were compared among thetested streptococci, closely related streptococci showedsimilar sensitivity to xylitol. Taken together, fructose PTSsmay mediate the sensitivity to xylitol in oral streptococci.
참고문헌 (24)
- Herzberg MC, "Platelet-streptococcal interactions in endocarditis", Crit Rev Oral Biol Med, 7, pp.222~236 (1996)
- Loesche WJ, "Role of Streptococcus mutans in human dental decay", Microbiol Rev, 50, pp.353~380 (1986)
- Whiley RA, "Current classification of the oral streptococci", Oral Microbiol Immunol, 13, pp.195~216 (1998)
- Facklam R, "What happened to the streptococci : overview of taxonomic and nomenclature changes", Clin Microbiol Rev, 15, pp.613~630 (2002)
- Cvitkovitch DG, "Regulation of sugar transport via the multiple sugar metabolism operon of Streptococcus mutans by the phosphoenolpyruvate phosphotransferase system", J Bacteriol, 177, pp.5704~5706 (1995)
- Escalante A, "Current knowledge of the Escherichia coli phosphoenolpyruvatecarbohydrate phosphotransferase system : peculiarities of regulation and impact on growth and product formation", Appl Microbiol Biotechnol, 94, pp.1483~1494 (2012)
- Vadeboncoeur C, "The phosphoenolpyruvate : sugar phosphotransferase system of oral streptococci and its role in the control of sugar metabolism", FEMS Microbiol Rev, 19, pp.187~207 (1997)
- Van Loveren C., "Sugar alcohols: what is the evidence for caries-preventive and caries-therapeutic effects?", Caries Res, 38, pp.286~293 (2004)
- 나희삼, "Effect of Xylitol on various Oral bacteria", International Journal of Oral Biology, 38(4), pp.175~180 (2013), 대한구강생물학회[DOI]
- Assev S, "Evidence for presence of a xylitol phosphotransferase system in Streptococcus mutans OMZ 176", Acta Pathol Microbiol Immunol Scand B, 92, pp.89~92 (1984)
- Assev S, "Further studies on the growth inhibition of Streptococcus mutans OMZ 176 by xylitol", Acta Pathol Microbiol Immunol Scand B, 94, pp.97~102 (1986)
- Trahan L, "Transport and phosphorylation of xylitol by a fructose phosphotransferase system in Streptococcus mutans", Caries Res, 19, pp.53~63 (1985)
- Bar A, "Caries prevention with xylitol. A review of the scientific evidence", World Rev Nutr Diet, 55, pp.183~209 (1988)
- Tanzer JM, "Xylitol chewing gum and dental caries", Int Dent J, 45, pp.65~76 (1995)
- Trahan L, "Xylitol : a review of its action on mutans streptococci and dental plaque--its clinical significance", Int Dent J, 45, pp.77~92 (1995)
- Lengeler JW, "Enzymes II of the phospho enol pyruvate-dependent phosphotransferase systems : their structure and function in carbohydrate transport", Biochim Biophys Acta, 1188, pp.1~28 (1994)
- Postma PW, "Phosphoenolpyruvate : carbohydrate phosphotransferase systems of bacteria", Microbiol Rev, 57, pp.543~594 (1993)
- Deutscher J, "How phosphotransferase system-related protein phosphorylation regulates carbohydrate metabolism in bacteria", Microbiol Mol Biol Rev, 70, pp.939~1031 (2006)
- Abranches J, "Characterization of Streptococcus mutans strains deficient in EIIAB Man of the sugar phosphotransferase system", Appl Environ Microbiol, 69, pp.4760~4769 (2003)
- Ramseier TM, "In vitro binding of the pleiotropic transcriptional regulatory protein, FruR, to the fru, pps, ace, pts and icd operons of Escherichia coli and Salmonella typhimurium", J Mol Biol, 234, pp.28~44 (1993)
- Hellinga HW, "Mutations in the active site of Escherichia coli phosphofructokinase", Nature, 327, pp.437~439 (1987)
- Alpert CA, "Phosphoenolpyruvate-dependent protein kinase enzyme I of Streptococcus faecalis : purification and properties of the enzyme and characterization of its active center", Biochemistry, 24, pp.959~964 (1985)
- Weigel N, "Sugar transport by the bacterial phosphotransferase system. Phosphoryl transfer reactions catalyzed by enzyme I of Salmonella typhimurium", J Biol Chem, 257, pp.14477~14491 (1982)
- Koch S, "Identification of a site in the phosphocarrier protein, HPr, which influences its interactions with sugar permeases of the bacterial phosphotransferase system : kinetic analyses employing site-specific mutants", J Bacteriol, 178, pp.1126~1133 (1996)