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Application of Dual-Frequency Ultrasound for Treating the Ulcerative Necrobiosis Lipoidica

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초록

Necrobiosis lipoidica (NL) is a rare, idiopathic, chronic granulomatous inflammatory disease of collagen degeneration with the risk of ulceration. Many procedures have been proposed to treat this rare disease. In this study, we applied LDM®-MED for the management of NL, and this condition in our patient was chronic and refractory to other therapeutic options. To the best of our knowledge, no study has explored treatment of NL using ultrasound. Our results suggest that application of LDM®-MED seems to be an effective treatment option for NL. Long-term and systematic studies are needed to determine whether such application of LDM®-MED will be an innovative and effective treatment option for NL and various kinds of chronic wounds.

Abstract

Necrobiosis lipoidica (NL) is a rare, idiopathic, chronic granulomatous inflammatory disease of collagen degeneration with the risk of ulceration. Many procedures have been proposed to treat this rare disease. In this study, we applied LDM®-MED for the management of NL, and this condition in our patient was chronic and refractory to other therapeutic options. To the best of our knowledge, no study has explored treatment of NL using ultrasound. Our results suggest that application of LDM®-MED seems to be an effective treatment option for NL. Long-term and systematic studies are needed to determine whether such application of LDM®-MED will be an innovative and effective treatment option for NL and various kinds of chronic wounds.

참고문헌 (12)

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  4. Hocqueloux L, "Ulcerated necrobiosis lipoidica associated with insulindependent diabetes mellitus. Beneficial effect of corticosteroid therapy by oral administration", Presse Med, 25, pp.25~27 (1996)
  5. Petzelbauer P, "Necrobiosis lipoidica:treatment with systemic corticosteroids", Br J Dermatol, 126, pp.542~545 (1992)
  6. Tan E, "Systemic corticosteroids for the outpatient treatment of necrobiosis lipoidica in a diabetic patient", J Dermatolog Treat, 18, pp.246~248 (2007)
  7. Kruglikov I, "Dual treatment strategy by venous ulcers: pilot study to dual-Frequency ultrasound application", J Cosmet Dermatol Sci Appl, 1, pp.157~163 (2011)
  8. Sibbald C, "Necrobiosis lipoidica", Dermatol Clin, 33, pp.343~360 (2015)
  9. Omugha N, "The management of hard-toheal necrobiosis with PROMOGRAN", Br J Nurs, 12(15Suppl), pp.S14~S20 (2003)
  10. Simcock JW, "Treatment of ulcerated necrobiosis lipoidica with ovine forestomach matrix", J Wound Care, 22, pp.383~384 (2013)
  11. Spenceri EA, "Topically applied bovine collagen in the treatment of ulcerative necrobiosis lipoidica diabeticorum", Arch Dermatol, 133, pp.817~818 (1997)
  12. McMurtry AL, "Expression of HSP70 in healing wounds of diabetic and nondiabetic mice", J Surg Res, 86, pp.36~41 (1999)

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