유통생약 황금의 품질모니터링 연구
Quality Monitoring of Distributed Herbal Medicine, Scutellariae Radix
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참고문헌
키워드
초록
This study was investigated that quality inspection of distributed Scutellariae Radix in Korea. To evaluate the quality of these herbal medicines, we carried out TLC pattern, foreign matter in purity, loss on drying, ash, acid-insoluble ash, oil content, dilute ethanol-soluble, water-soluble, ether-soluble extracts contents, quantitative analyses, residual SO2, individual heavy metals and organochlorine pesticides. To measure contents of baicalin, baicalein and wogonin, we were quantitative analyzed using HPLC. The average contents of baicalin, baicalein and wogonin were detected by 13.28 (± 0.43)%, 1.17 (± 0.04)% and 0.40 (± 0.02)%, respectively. Each average contents As, Cd, Hg and Pb was 0.059 (± 0.054)㎎ · ㎏−1, 0.019 (± 0.010)㎎ · ㎏−1, 0.017 (± 0.057) ppm and 0.242 (± 0.084)㎎ · ㎏−1, respectively.
Abstract
This study was investigated that quality inspection of distributed Scutellariae Radix in Korea. To evaluate the quality of these herbal medicines, we carried out TLC pattern, foreign matter in purity, loss on drying, ash, acid-insoluble ash, oil content, dilute ethanol-soluble, water-soluble, ether-soluble extracts contents, quantitative analyses, residual SO2, individual heavy metals and organochlorine pesticides. To measure contents of baicalin, baicalein and wogonin, we were quantitative analyzed using HPLC. The average contents of baicalin, baicalein and wogonin were detected by 13.28 (± 0.43)%, 1.17 (± 0.04)% and 0.40 (± 0.02)%, respectively. Each average contents As, Cd, Hg and Pb was 0.059 (± 0.054)㎎ · ㎏−1, 0.019 (± 0.010)㎎ · ㎏−1, 0.017 (± 0.057) ppm and 0.242 (± 0.084)㎎ · ㎏−1, respectively.
참고문헌 (13)
- Horvath CR, "Identification and quantification of eight flavones in root and shoot tissues of the medical plant Huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection", Journal of Chromatography A, 1062, pp.199~207 (2005)
- Kim DH, "Shot-term feeding of baicalin inhibits age-associated NF-κB activation", Mechanism of Ageing and Development, 127(9), pp.719~725 (2006)
- Kim MS, "Effects of topping time and split fertilization on growth and root yield of Scutellaria baicalensis G", Korean J. Medicinal Crop Sci, 6(4), pp.271~276 (1998)
- 김석창, "황금으로부터 항산화 활성 성분의 분리", 한국약용작물학회지, 14(4), pp.212~216 (2006), 한국약용작물학회
- Kim YH, "Liquid chromatography with tandem mass spectrometry for the simultaneous determination of baicalein, baicalin, oroxylin A and wogonin in rat plasma", Journal of Chromatography B, 844(2), pp.261~267 (2006)
- Kumagai T, "Scutellaria baicalensis, a herbal medicine: Anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines", Leukemia Research, 31(4), pp.523~530 (2007)
- Lee MS, "Plant regeneration from leaf tissue culture and some effective substances in Scutellaria baicalensis G", Korean J. Medicinal Crop Sci, 1(1), pp.43~48 (1993)
- Li HB, "Isolation and purification of baicalein, wogonin and oroxylin A from the medical plant Scutellaria baicalensis by high-speed counter-current chromatography", Journal of Chromatography A, 1074, pp.107~110 (2005)
- Li HB, "Separation methods used for Scutellaria baicalensis active components", Journal of Chromatography B, 812, pp.277~290 (2004)
- Beong Ou Lim, "Inhibitory Effect of Scutellaria baicalensis Root Extract on ChemicalMediator Release and Immune Response", 한국약용작물학회지, 15(2), pp.132~137 (2007), 한국약용작물학회
- Yu K, "Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Scutellaria baicalensis Georgi using capillary electrophoresis", Journal of Pharmaceutical and Biomedical Analysis, 43(2), pp.540~548 (2007)
- Zgórka G, "Retention behavior of silica-bonded and novel polymeric reversed-phase sorbents in studies on flavones as chemotaxonomic markers of Scutellaria L. genus", Journal of Chromatography A, 1120, pp.230~236 (2006)
- Zhang Y, "Protective effect of flavonoids from Scutellaria baicalensis Georgi on cerebral ischemia injury", Journal of Ethnopharmacology, 108(3), pp.3585~360 (2006)