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생쥐에서 디젤배기가스 입자에 의한 기도염증과 기도 과민성에 미치는 홍삼 조사포닌의 영향

The Effect of Crude Saponins of Korean Red Ginseng against Airway Inflammation and Airway Hyperresponsiveness Induced by Diesel Exhaust Particles in Mice

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Abstract

The objective of this study was to investigate the effect of crude ginseng total saponins (CGS) against airway inflammation (AI) and airway hyperresponsiveness (AH) induced by diesel exhaust particles (DEP) in mice. AI and AH were induced by the intratracheal instillation with 0.1㎎/㎖ of DEP suspension once a week for 10 weeks combined with ovalbumin (OVA) sensitization. Mice were also treated orally with 75㎎/㎖ of CGS, 5 days a week for 10 weeks. Oral CGS treatment decreased in the level of serum immunoglobulin (IgE) and histamine increased by DEP and OVA, and declined respiratory resistance. It also dropped an enhanced infiltration of eosinophils in the bronchoalveolar lavage fluid (BALF) of mice, and an increased T helper type 2 cell derived cytokine levels such as of interleukin (IL)-4, IL-13 and IL-5 in the BALF. However, it did not influence T helper type 1 cytokine such as interferon-gamma in the BALF. These results indicate that CGS may alleviate allergen-related AI and AH in mice and may play an important role in the modulation of asthmatic inflammation.

참고문헌 (36)

  1. Akiyama K, "Gas chromatographic analysis and aerosol mass spectrometer measurement of diesel exhaust particles composition", Talanta, 70, pp.178~181 (2006)
  2. Cho YS, "Relation between particulate matter measured by optical particle counter and mortality in Seoul, Korea, during 2001", Journal of Environmental Health, 71, pp.37~43 (2008)
  3. Choi KT, "Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng CA Meyer", Acta Pharmacologica Sinica, 29, pp.1109~1118 (2008)
  4. Finkelman FD, "Diesel exhaust particles suppress in vivo IFN-gamma production by inhibiting cytokine effects on NK and NKT cells", The Journal of Immunology, 172, pp.3808~3813 (2004)
  5. Finotto S, "Treatment of allergic airway inflammation and hyperrespon- siveness by antisense-induced local blockade of GATA-3 expression", The Journal of Experimental Medicine, 193, pp.1247~1260 (2001)
  6. Gowdy K, "Modulation of pulmonary inflammatory responses and antimicrobial defenses in mice exposed to diesel exhaust", Toxicology and Applied Pharmacology, 229, pp.310~319 (2008)
  7. Hammond H, "Differential capacity of CD8+ alpha or CD8- alpha dendritic cell subsets to prime for eosinophilic airway inflammation in the T-helper type 2-prone milieu of the lung", Allergy, 12, pp.1834~1840 (2004)
  8. Hofseth LJ, "Inflammation, cancer, and targets of ginseng", Journal of Nutrition, 137, pp.183S~185S (2007)
  9. Inoue KI, "Effects of pulmonary exposure to diesel exhaust particles on extrathoracic CD4 polarization in ahmatic mice", Immunophar-macology and Immunotoxicology, 28, pp.1~6 (2008)
  10. Kang KA, "Ginseng total saponin enhances the phagocytic capacity of canine peripheral blood phagocytes in vitro", The American Journal of Chinese Medicine, 36, pp.329~341 (2008)
  11. Kang KS, "ESR study on the structure and hydroxyl radical scavenging activity relationships of ginsenosides isolated from Panax ginseng C.A. Meyer", Biological Pharmaceutical Bulletin, 30, pp.917~921 (2007)
  12. Young Mi Kim, "Anti-allergic Activity of Oriental Medicinal Herbs", 한국약용작물학회지, 14(5), pp.282~288 (2006), 한국약용작물학회
  13. Kumar RK, "Interferon- gamma as a possible target in chronic asthma", Inflammation and Allergy - Drug Targets, 5(4), pp.253~256 (2006)
  14. Beong Ou Lim, "The Influence of Long-term Aloe Supplementon Anti-oxidative Defenses and Cholesterol Contentin Brain and Kidney of Aged Rats", 한국약용작물학회지, 15(5), pp.352~356 (2007), 한국약용작물학회
  15. 임흥빈, "홍삼의 장기 투여가 흰쥐 간 대사효소 유도에 미치는 영향", 한국약용작물학회지, 15(6), pp.437~443 (2007), 한국약용작물학회
  16. Lim HB, "Involvement of superoxide and nitric oxide on airway inflammation and hyperrespon-siveness induced by diesel exhaust particles in mice", Free Radical Biology and Medicine, 25, pp.635~644 (1998)
  17. Heung-BinLim, "Diesel Exhaust Particles and Airway Inflammation:Effect of Nitric Oxide Synthase Inhibitors", Journal of Korean Society for Atmospheric Environment, 18(E2), pp.121~128 (2002), 한국대기환경학회
  18. 임흥빈, "홍삼의 물추출물이 노화에 따른 흰쥐 간의 이물질대사 효소계에 미치는 영향", 한국약용작물학회지, 14(6), pp.329~335 (2006), 한국약용작물학회
  19. Heung-Bin Lim, "Influence of Long-term Supplementation with Korean Red Ginseng on in vivo Antioxidant Capacities in Rats", Food Science and Biotechnology, 18(1), pp.234~238 (2009), 한국식품과학회
  20. Lim S, "Effect of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose homeostasis in an obese insulin-resistant rat model", Metabolism, 58, pp.8~15 (2009)
  21. Liu J, "Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T healper genes and IgE production in vivo", Toxicological Science, 102, pp.76~81 (2008)
  22. Li YJ, "Disruption of Nrf2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in mice", Clinical Immunology, 128, pp.366~373 (2008)
  23. Nakajima H, "Role of cytokines in allergic airway inflammation", International Archives of Allergy and Immunology, 142, pp.265~273 (2007)
  24. Pawankar R, "Role of mast cells and basophils in chronic rhinosinusitis", Clinical Allergy and Immunology, 20, pp.93~101 (2007)
  25. Ris C, "US EPA health assessment for diesel engine exhaust : a review", Inhalation Toxicology, 19, pp.229~39 (2007)
  26. Sagai M, "Biological effects of diesel exhaust particles. I. In vitro production od superoxide and in vivo toxicity in mouse", Free Radical Biology and Medicine, 14, pp.37~47 (1993)
  27. Sagai M, "Biological effects of diesel exhaust particles (DEP). III. Pathogenesis of asthma-like symptoms in mice", Free Radical Biology and Medicine, 21, pp.199~209 (1996)
  28. Jeong-Ju Seo, "Inhibitory Effects of Ginseng Total Saponin on Up-Regulation of cAMP Pathway Induced by Repeated Administration of Morphine", Archives of Pharmacal Research, 31(2), pp.167~170 (2008), 대한약학회
  29. Shen HH, "Astragalus Membranaceus prevents airway hyperreactivity in mice related to Th2 response inhibition", Journal of Ethnopharmacology, 116, pp.363~369 (2008)
  30. Shigh BB, "Herbal treatments of asthma : a systematic review", Journal of Asthma, 44, pp.685~698 (2007)
  31. Takano H, "Modulation of the L-arginine-nitric oxide pathway in airway inflammation induced by diesel exhaust particles in mice", Toxicology, 139, pp.19~26 (1999)
  32. Takizawa H, "Role of inflammatory cells in the develop-ment of airway inflammation", Nippon Rinsho Journal, 61, pp.2107~2112 (2003)
  33. Theoharides TC, "The critical role of mast cells in allergy and inflammation", Annals of New York Academy of Science, 1088, pp.78~99 (2006)
  34. Vig, RS, "The role of stress in asthma : insite from studies on the effect of acute and chronic stressors in models of airway inflammation", Annals of New York Academy of Science, 1088, pp.65~77 (2006)
  35. Wichmann HE, "Diesel exhaust particles", Inhalation Toxicology, 19, pp.241~244 (2007)
  36. Yang EJ, "Inhibitory effects of Duchesnea chrysantha extract on ovalbumin-induced lung inflammation in a mouses model of asthma", Journal of Ethnopharmacology, 118, pp.102~107 (2008)

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