마가목의 항암활성탐색
Anticancer Effect of Sorbus commixta Hedl extracts
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Abstract
We prepared extracts from bark, leaf and fruit of Sorbus commizta Hedl using by water and ethanol. To test mutagenicity and antimutagenicity on extracts, we used Rec assay and Ames test. The result of Rec assay, the extracts of the Sorbus commixta Hedl did not show a DNA-damage activity. The results of Ames test were provided that extracts of Sorbus commixta Hedl showed 43~73% antimutagenic activities. In the inhibition ratio of the growth of several Human cancer cells (A549,HepG2, MCF7), 91% of MCF7 cell growth, 94% of A549 cell growth and 91% HepG2 cell growth were inhibited by adding 1 of fruit ethanol extracts, bark ethanol extracts and fruit ethanol extracts, respectively. There was a little cytotoxicity on human normal hephatocyte (WRL68), extracts(1㎎/㎖ )showed over the 70% survival.