중점관리기준에 기초한 국내생산 당귀의 산지 수확 후 아플라톡신의 안전성 평가 연구
Safety Evaluation from Aflatoxin risk of Korean Angelicae Gigantis Radix Based on Critical Control Points
1
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
HACCP methodology was applied in the post-harvest processing and storage of domestic medicinal produces. Particularly in terms of mold and mycotoxin contamination, candidate critical control points (CCP) in the conventional practice in Korean farms were selected and monitored by comparing with on the standard guided processing and storage. When each processing of Angelicae Gigantis Radix were assessed for their safety, the drying steps such as the sun drying or the thermal drying depending on each farm made differences in mold contamination. Moreover, the storage conditions before or after the processing were another critical determinant in the fungal contamination. In other words, storage under 4℃ rather than at room temperature was favorable for reducing mold growth in the harvested crops. Occurrence rate of Aflatoxin B1 (AFB_1) in Angelicae Gigantis Radix were 12.8%, but amount of AFB_1 in all the collected samples were below 10 ppb regulatory limit allowed in Korea. However, for a few samples of Angelicae Gigantis Radix, still relatively high levels of total amount of the major aflatoxins (aflatoxin B_1 + B_2 + G_1 + G_2) were observed around 0.18~49.94 ppb, which is not regulated presently in Korea. It thus can be suggested that post-harvest processing and storage of Korean medicinal crops need further investigation and monitoring to establish the Good Agricultural Practice (GAP), particularly to minimize microbial risk including mold and mycotoxin contamination under the changing climate. Additionally, it is also warranted for new enacting of regulatory limits for total aflatoxins in the medicinal crops.
Abstract
HACCP methodology was applied in the post-harvest processing and storage of domestic medicinal produces. Particularly in terms of mold and mycotoxin contamination, candidate critical control points (CCP) in the conventional practice in Korean farms were selected and monitored by comparing with on the standard guided processing and storage. When each processing of Angelicae Gigantis Radix were assessed for their safety, the drying steps such as the sun drying or the thermal drying depending on each farm made differences in mold contamination. Moreover, the storage conditions before or after the processing were another critical determinant in the fungal contamination. In other words, storage under 4℃ rather than at room temperature was favorable for reducing mold growth in the harvested crops. Occurrence rate of Aflatoxin B1 (AFB_1) in Angelicae Gigantis Radix were 12.8%, but amount of AFB_1 in all the collected samples were below 10 ppb regulatory limit allowed in Korea. However, for a few samples of Angelicae Gigantis Radix, still relatively high levels of total amount of the major aflatoxins (aflatoxin B_1 + B_2 + G_1 + G_2) were observed around 0.18~49.94 ppb, which is not regulated presently in Korea. It thus can be suggested that post-harvest processing and storage of Korean medicinal crops need further investigation and monitoring to establish the Good Agricultural Practice (GAP), particularly to minimize microbial risk including mold and mycotoxin contamination under the changing climate. Additionally, it is also warranted for new enacting of regulatory limits for total aflatoxins in the medicinal crops.
참고문헌 (16)
- Abeywickrama K, "Toxigenic Aspergillus flavus and aflatoxins in Sri Lankan medicinal plant material", Mycopathologia, 113, pp.187~190 (1991)
- Ali N, "Evaluation of a method to determine the natural occurrence of aflatoxins in commercial traditional herbal medicines from Malaysia and Indonesia", Food and Chemical Toxicology, 43, pp.1763~1772 (2005)
- Brase S, "Chemistry and biology of mycotoxins and related fungal metabolites", Chemical Reviews, 109, pp.3903~3990 (2009)
- D. E. Marin, "Changes in performance, blood parameters, humoral and cellular immune responses in weanling piglets exposed to low doses of aflatoxin", Journal of Animal Science, 5, pp.1250~1257 (2002)
- European Commission, "Setting maximum levels for certain contaminants in food stuffs (Commission Regulation (EC) No. 466", 2001. 8 March 2001), 2001, pp.(L077), 1~13
- Food and Agriculture Organization and World Health Organization, "Joint FAO", WHO Expert Committee on Food Additives, 1997, ~
- Ip SP, "Determination of aflatoxins in Chinese medicinal herbs by high-performance liquid chromatography using immunoaffinity column cleanup improvement of recovery", Journal of Chromatography, 1135, pp.241~244 (2006)
- Katerere DR, "A preliminary survey of mycological and fumonisin and aflatoxin contamination of African traditional herbal medicines sold in South Africa", Human Experimental Toxicology, 27, pp.793~798 (2008)
- 이성득, "한약재 중 아플라톡신 Monitoring", 한국약용작물학회지, 18(5), pp.338~344 (2010), 한국약용작물학회
- Pozzi CR, "Postharvest and stored corn in Brazil: mycoflora interaction, abiotic factors and mycotoxin occurrence", Food Additives and Contaminants, 12, pp.313~319 (1995)
- Reddy SV, "Aflatoxins B1 in different grades of chillies (Capsicum annum L.) in India as determined by indirect competitive-ELISA", Food Additives and Contaminants, 18, pp.553~558 (2001)
- Tassaneeyakul W, "Contamination of aflatoxins in herbal medicinal products in Thailand", Mycopathologia, 158, pp.239~244 (2004)
- Trucksess MW, "Mycotoxins in botanicals and dried fruits: a review", Food Additives and Contaminants, 25, pp.181~192 (2008)
- Turner PC, "Reduction in exposure to carcinogenic aflatoxins by postharvest intervention measures in west Africa: a community-based intervention study", The Lancet, 365, pp.1950~1956 (2005)
- Wild CP, "Aflatoxin exposure in developing countries: the critical interface of agriculture and health", Food and Nutrition Bulletin, 28, pp.S372~380 (2007)
- Wogan. G. N, "Dose-response characteristics of Aflatoxin B1 carcinogenesis in the rat", Cancer Research, 27, pp.2370~2376 (1967)