Sesamin from Artemisia littoricola Attenuates UVA-Induced MMP Expression in Human Dermal Fibroblasts
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Background: Photoaging is predominantly caused by ultraviolet (UV) radiation and is a major contributor to premature skin aging. Photoaging of the skin is characterized by oxidative stress and collagen degradation. Damage to skin extracellular matrix proteins is mainly caused by the upregu- lation of matrix metalloproteinases (MMPs). Sesamin, a lignan commonly found in sesame seeds, possesses antioxidant, anti-inflammatory, and other beneficial properties, making it a promising compound for skin photoprotection. Methods and Results: The photoaging amelioration potential of sesamin isolated from Artemisia littoricolawas investigated using UVA-stimulated human dermal fibroblasts (HDFs). Sesamin sig- nificantly reduced intracellular ROS accumulation and attenuated UVA-mediated elevation in secreted MMP-1. Sesamin also suppressed phosphorylation of the terminal mitogen-activated pro- tein kinases (MAPKs), ERK, JNK, and p38. MMP-1 and MMP-3 protein levels were also down- regulated, and collagen content was preserved. Conclusions: These results demonstrate that sesamin protects against UVA-induced damage in HDFs by reducing oxidative stress and inhibiting MAPK-mediated MMP expression. These results indicate that sesamin is a potential natural photoprotective agent with potential applications in skin care. Isolation of sesamin from A. littoricolahighlights the relevance of medicinal crops as a source of bioactive compounds for cosmeceutical applications.
Abstract
Background: Photoaging is predominantly caused by ultraviolet (UV) radiation and is a major contributor to premature skin aging. Photoaging of the skin is characterized by oxidative stress and collagen degradation. Damage to skin extracellular matrix proteins is mainly caused by the upregu- lation of matrix metalloproteinases (MMPs). Sesamin, a lignan commonly found in sesame seeds, possesses antioxidant, anti-inflammatory, and other beneficial properties, making it a promising compound for skin photoprotection. Methods and Results: The photoaging amelioration potential of sesamin isolated from Artemisia littoricolawas investigated using UVA-stimulated human dermal fibroblasts (HDFs). Sesamin sig- nificantly reduced intracellular ROS accumulation and attenuated UVA-mediated elevation in secreted MMP-1. Sesamin also suppressed phosphorylation of the terminal mitogen-activated pro- tein kinases (MAPKs), ERK, JNK, and p38. MMP-1 and MMP-3 protein levels were also down- regulated, and collagen content was preserved. Conclusions: These results demonstrate that sesamin protects against UVA-induced damage in HDFs by reducing oxidative stress and inhibiting MAPK-mediated MMP expression. These results indicate that sesamin is a potential natural photoprotective agent with potential applications in skin care. Isolation of sesamin from A. littoricolahighlights the relevance of medicinal crops as a source of bioactive compounds for cosmeceutical applications.