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논문KCI 등재

정신분열병에서 TAP2 유전자의 다형성

Polymorphisms of TAP2 Gene in Schizophrenia

전태연|이경욱|배치운|송정민|표철우
대한신경정신의학회 (Korean Neuropsychiatric Association)|2004.05|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제43권 제3호|pp. 277-282

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참고문헌

키워드

정신분열병 · TAP2 일배체 · 유전자 다형성.Schizophrenia · TAP2 haplotype · Polymorphisms.
주제분류정신과학

초록

Abstract

Objectives：The genes for transporters associated with antigen processing (TAP) are located near to HLA class II coding regions and related to antigen presentation. Therefore polymorphisms of TAP might alter the T-cell mediated immune response and influence susceptibility to schizophrenia, which is known to have alterations in T-cell immunity. The aim of this study was to verify the relationship between schizophrenia and polymorphisms of TAP2 genes. Methods：257 patients with schizophrenia and 184 normal controls participated in this study. TAP2 polymorphic residues at positions 379, 565 and 665 were typed using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and single-strand conformation polymorphism (SSCP). The resulted products, TAP2379, TAP2565 and TAP2665 were assessed. Results：The frequency of TAP2 alleles did not differ between patients with schizophrenia and controls. The polymorphic sites TAP2379, TAP2565 and TAP2665 did not show any difference in their amino acid substitution frequencies. Conclusion：This study did not show the association of the TAP2 gene with schizophrenia in Korean population. Further studies are needed to test the informative value of haplotypes including other polymorphic sites. (J Korean Neuropsychiatr Assoc 2004;43(3):277-282)

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