본문 바로가기
KERD
논문KCI 등재

공황장애 환자에서 약물 치료와 심박동수 변이 (Heart Rate Variability)의 관련성

The Relation between Heart Rate Variability and Pharmacotherapy in Patients with Panic Disorder

윤혜영|최영희|우종민|김응석
대한신경정신의학회 (Korean Neuropsychiatric Association)|2005.05|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제44권 제3호|pp. 342-349

1

조회

0

다운로드

13

인용

0

참고문헌

주제분류정신과학

초록

Abstract

Objectives：This study was designed to evaluate relation between 6 weeks pharmacotherapy and the alteration of autonomic nervous system in patient with panic disorder. Methods：The subjects were patients (n=44) who met DSM-IV criteria for panic disorder with or without agoraphobia. They were measured Anxiety Disorder Inventory Schedule-Panic attack & agoraphobia (ADIS-P & A), Clinical Global Impression CGI) Hamilton Rating Scale for depression (HAM-D), Panic Disorder Severity Scale (PDSS) and heart rate variability (HRV) before and after 6 weeks pharmacotherapy. We prescribed paroxetine primarily and benzodiazepine (clonazepam,alprazolam) in case needed. For analysis, we performed paired sample t-test, partial correlation, stepwise multiple regression. Results：After 6 weeks pharmacotherapy, a assessed clinical inventories significant improved. In HRV, patients showed stabilized sympathetic activity (LF, Normalized LF, log_LF), increased parasympathetic activity (Normalized HF). There were significant correlation between symptom improvement with parasympathetic components and symptom aggravation with sympathetic components. Multiple regression analysis showed that Normalized HF and TP were best explanatory variables of symptom improvement. Conclusion：This study suggests that 6 weeks pharmacotherapy is related to the alteration of autonomic nervous system and clinical improvement.

참고문헌 (27)

  1. "Autonomicreactivity of panic patients during a CO2 inhalation procedure", 11, pp.15~26 (2000), Depress Anxiety
  2. "Comparison of panic symptom sequences andpathophysiologic models", 21, pp.101~111 (1990)
  3. "Carbon dioxide hypersensitivity:hyperventilation and panic disorder", 150, pp.1149~1157 (1993)
  4. "Beat to beatvariability in cardiovascular variables noise or music", pp.1139~1148
  5. "Anxiety and autonomic flexibility:acardiovascular approach", 47, pp.243~263 (1998)
  6. "심박동수 변이 (Heart rate variability) 측정법의 개념과임상적 활용. 정신신체의학", 12, pp.3~14 (2004)
  7. "Task Force of The European Society of Cardiology and The NorthAmerican Society of Pacing and Electrophysiology Standards of measurement", 17, pp.354~381 (1996)
  8. "Autonomic nervous system tests in psychiatry implications and potential uses of heart rate variability", pp.21~28
  9. "Power spectral analysis of heartrate variability;a tool to explore neural regulatory mechanism", 71, pp.1~2 (1994)
  10. "Heart rate variability,a measure of cardiac autonomic tone", 127, pp.1376~1381 (1994)
  11. "Power spectrum analysis of heart rate fluctuation;a quantitative probeof beat-to-beat cardiovascular control", 213, pp.220~222 (1981)
  12. "Assessment of autonomic function in humans by heart ratespectral analysis", 148, pp.151~153 (1985)
  13. "Power spectral analysis of heart rate and arterial pressure variabilitiesas a marker of sympatho-vagal interaction in man and consciousdog", 59, pp.178~193 (1986)
  14. "Autonomic characteristics of nonclinical panic andblood phobia", 34, pp.298~310 (1993)
  15. "Effectiveness and safety of benzodiazepines.J Clin Psychopharmacol", 19, pp.2~11 (1999)
  16. "Current concepts in the treatment of panic disorder", 60, pp.16~21 (1999)
  17. "Paroxetine increase heart rate variability in Panicdisorder", 17, pp.370~376 (1997)
  18. "Effect of paroxetine on heart rate variability in panic disorder;analysis of Holter records", 39, pp.522~ (1996)
  19. "Heart ratevariability as predictor of nonresponse to mirtazapine in panic disorder:a preliminary study", 17, pp.69~74 (2002)
  20. "The Anxiety disorders InterviewSchedule for DSM-IV. Albany, NY." (1997)
  21. "EDCEU assessment manual for psychopharmacology US Dept of Health", pp.217~222 (1976)
  22. "Development of a rating scale for primary depressiveillness", 6, pp.278~296 (1967)
  23. "Reliability and validity of panic disorder severity scale;replication and extension", 35, pp.293~296 (2001)
  24. "한국판 공황장애 심각도 척도의 개발", 10, pp.140~151 (2001)
  25. "Functional anatomy of the autonomic nervous system", 10, pp.2~13 (1993)
  26. "Mortality among outpatients withanxiety disorders", 143, pp.508~510 (1986)
  27. "The effect of amitriptyline,doxepin,fluvoxamine andparoxetine treatment on heart rate variability", 14, pp.392~395 (1994)

관련 논문AI추천

한국 범불안장애 환자의 자율신경심장기능김현, 남민, 이강준, 이승환, 정영조, 추정숙대한생물정신의학회 · 생물정신의학2005 · 제12권 제1호심박변이도에 대한 이해와 불안장애의 평가 및 치료에서의 활용강지인대한불안의학회 · 대한불안의학회지2025 · 제21권 제1호정신과에서 심박 변이도(Heart Rate Variability)의 이용김원, 우종민, 채정호대한신경정신의학회 · 신경정신의학2005 · 제44권 제2호정신과 외래환자의 약물치료 반응과 심박동 변이의 변화 양상김도훈, 김인주, 김형태, 손봉기, 이상규, 이홍석대한신경정신의학회 · 신경정신의학2006 · 제45권 제6호주요우울장애 환자에서 24시간 심박변이도 분석강은호, 강중근, 우종민, 이선미대한불안의학회 · 대한불안의학회지2013 · 제9권 제2호공황장애에서 단기약물치료가 불안민감도와 삶의 질 및 기능장애에 미치는 영향김보라, 오윤혜, 유범희, 최관우, 허정윤대한불안의학회 · 대한불안의학회지2013 · 제9권 제1호

이 간행물의 다른 논문 (13건)

＂신경정신의학＂ 온라인 논문 시스템오병훈pp. 279-380학술지 ＂신경정신의학＂ 온라인 논문 투고 및 심사 시스템의 실제오병훈, 차경렬, 김주한pp. 281-386정신분열병과 Neuregulin 1 유전자의 연합연구장수연, 이유상, 홍경수, 윤세창, 김종원, 박동연, 장용이, 조승희, 전현옥, 조은영pp. 287-294만화 과제를 이용한 정신분열병 환자의 사회인지 능력의 측정이경진, 신용욱, 홍순범, 오정은, 나명현, 이영호, 신민섭, 권준수, 하태현, 노규식pp. 295-302한국판 사건충격척도 수정판의 신뢰도 및 타당도 연구조수진, 김태형, 최말례, 은헌정, 권태완, 이선미pp. 303-310
원문 보기