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논문KCI 등재

정신분열병 환자에서 세가지 청각 자극 ＂Oddball＂ 모형에 의한 사건관련전위 P3a와 P3b

Event-Related Potential P3a and P3b using 3-Stimulus Auditory "Oddball" Paradigm in the Patients with Schizophrenia

한상익|전양환|박이진|진용탁|남지민
대한신경정신의학회 (Korean Neuropsychiatric Association)|2005.09|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제44권 제5호|pp. 568-575

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참고문헌

주제분류정신과학

초록

Abstract

Objectives：Using 3-stimulus auditory “oddball” paradigm reflecting fronto/central and temporo/parietal functions simultaneously, we examined patients with schizophrenia. Methods：Fifteen patients with schizophrenia from outpatient clinic and fifteen normal controls from hospital staffs were recruited for the study. To elicit P3a and P3b, 3-stimulus auditory oddball paradigm was employed. The 3-stimulus auditory oddball paradigm was composed of standard tone (1,000 Hz, 75 dB, 80%), target tone (2,000 Hz, 75 dB, 10%) and distracter(White noise, 95 dB, 10%). Results：P3a and P3b were prominent in fronto/central and temporo/parietal areas, respectively, in both schizophrenics and normal controls. The P300 amplitude in patients with schizophrenia was reduced across P3a and P3b (p<0.01). The P300 latency in patients with schizophrenia was delayed across P3a and P3b (p<0.01). Conclusion：These results were consistent with frontal and temporo-parietal lobe dysfunctions in schizophrenics. The 3-stimulus auditory paradigm could be applied for patients with schizophrenia and useful for further exploration the disorder.

참고문헌 (54)

  1. "Diagnostic and statistical manualof mental disorders" (2000), American PsychiatricAssociation
  2. "Textbook of psychiatry", para(id), pp.411~463 (1994), American Psychiatric Press
  3. "Introduction and overview of schizophrenia", pp.889~902 (1995)
  4. "The diagnosis of schizophrenia Contemporary issues in the treatment of schizophrenia", pp.83~108 (1995), American Psychiatric Press
  5. "Schizophrenia. In: Tasman A, Kay J, LiebermanJA. Psychiatry. Philadelphia: Saunders", pp.927~965 (1997)
  6. "Concepts of schizophrenia. In: Hirsch SR, Weinberger DR.editors. Schizophrenia. Cambridge: Blackwell Science", pp.3~14 (1995)
  7. "Uniting Kraepelinand Bleuler:the psychology schizophrenia and the biology oftemporal lobe abnormality", 1, pp.36~56 (1993)
  8. "On the clinical application of P300", 31, pp.647~649 (1992)
  9. "Meta-analysis of P300 normative aging studies", 33, pp.334~353 (1996)
  10. "P300 clinical utility and control of variability", 15, pp.14~33 (1998)
  11. "P300, handedness, and corpus callosal size:gender, modality, and task", 31, pp.163~174 (1999)
  12. "The P300 wave of the human event-related potential", 9, pp.456~479 (1992)
  13. "The effect of motivational instructionson P300 amplitude", 30, pp.232~239 (2000)
  14. "Meta-analysis of P300 and schizophrenia:Patients,Paradigm,and clinical implications", 40, pp.684~701 (2003)
  15. "P300 asymmetry in schizophrenia:a meta-analysis", 104, pp.61~74 (2001)
  16. "On the relationship ofP3a and the Novelty-P3", 56, pp.207~218 (2001)
  17. "A componential analysis of the ERPelicited by novel events using a dense electrode array", 36, pp.409~414 (1999)
  18. "ERP amplitude and scalp distribution totarget and novel events:effects of temporal order in young,middleagedand older adults", 2, pp.49~63 (1994)
  19. "Stimulus novelty,task relevanceand the visual evoked potential in man", 39, pp.131~143 (1975)
  20. "Autism:processingof novel auditory information assessed by event-related brainpotential", 59, pp.238~248 (1984)
  21. "Decreased response to novel stimuli after prefrontal lesionsin man", 59, pp.9~20 (1984)
  22. "P300 generation by novel so matosensorystimuli", 78, pp.50~55 (1991)
  23. "Two varieties of long-latencypositive waves evoked by unpredictable auditory stimuli in man", 38, pp.387~401 (1975)
  24. "Auditory and visual P300 topography from a 3stimulus paradigm", 110, pp.463~468 (1999)
  25. "The positive and negative syndromescale(PANSS)for schizophrenia", 2, pp.261~276 (1987)
  26. "A solution forreliable and valid reduction of ocular artifacts,applied to the P300ERP", 23, pp.695~703 (1986)
  27. "P300 in clinical applications. In: Niedermeyer, Lopes da SilvaF. editors. Electroencephalography, basic principles, clinical applicationsand related fields.", pp.1073~1091 (1999), Urban & Schwarzenberg
  28. "Amplitudes of auditory P300 in remittedand residual schizophrenics:correlations with clinical features", 27, pp.54~60 (1993)
  29. "P300 reductionand prolongation with illness duration in schizophrenia", 47, pp.413~427 (2000)
  30. "Relationship between auditory P300 amplitude and age of onset ofschizophrenia in older patients", 79, pp.241~254 (1998)
  31. "Auditory P300 amplitude as a state marker for positive symptomsin schizophrenia:cross-sectional and retrospective longitudinal studies", 59, pp.147~157 (2003)
  32. "P300 amplitude is related to clinical state in severely and moderatelyill patients with schizophrenia", 46, pp.94~101 (1999)
  33. "Smaller auditory P300 amplitude in schizophrenics in remission", 33, pp.171~174 (1995)
  34. "Effectsof olanzapine on auditory P300 in schizophrenia", 27, pp.173~177 (2003)
  35. "Changes inauditory P300 with clinical remission in schizophrenia:effects offacial-affect stimuli", 55, pp.347~352 (2001)
  36. "P300 subcomponents reflect different aspects of psychopathology inschizophrenia", 45, pp.116~126 (1999)
  37. "P300 and symptom improvement in schizophrenia", 158, pp.55~65 (2001)
  38. "P300 responses to novel auditory stimuli inhospitalized schizophrenic patients", 36, pp.527~542 (1994)
  39. "Hypofrontality in neuroleptic-naive patients and in patientswith chronic schizophrenia.Assessment with xenon 133 single-photonemission computed tomography and the Tower of London", 49, pp.943~958 (1992)
  40. "Correlationof negative symptoms in schizophrenia with frontal lobe parametersin magnetic resonance imaging", 159, pp.130~134 (1991)
  41. "Negative symptoms and hypofrontality in chronic schizophrenia", 49, pp.959~965 (1992)
  42. "On the utility of P3 latency as an index of mental chronometry", 34, pp.131~156 (1997)
  43. "Augmenting mental chronometry:the P300 as a measure of stimulus evaluation time", 197, pp.792~795 (1977)
  44. "Lower-bandpass filter frequency in P3 experiments:a possible causefor divergent results in schizophrenia research", 27, pp.667~670 (1990)
  45. "지형학적 청각 사건관련전위 P300과 정신분열증의 정신병리", 36, pp.1148~1153 (1997)
  46. "P300,clinical symptoms,and neuropsychological parameters in acute and remittedschizophrenia:A preliminary report", 31, pp.1065~1069 (1992)
  47. "P300 delay and attenuation in schizophrenia:reversal by neurolepticmedication", 44, pp.466~474 (1998)
  48. "Clinicalapplication of the P3 component of event-related potentials.Ⅱ.Dementia, depression and schizophrenia", pp.104~124, depression and schizophrenia
  49. "Neuropsychological and P300 abnormalities in schizophrenicsand their relatives", 23, pp.305~314 (1993)
  50. "Abnormalitiesof auditory event-related potentials in schizophrenia prior totreatment", 43, pp.244~253 (1998)
  51. "P3 in schizophreniais affected by stimulus modality, response requirements, medicationstatus, and negative symptoms", 46, pp.1035~1044 (1998)
  52. "Changes in auditory P3 event-related potential in schizophreniaand depression", 150, pp.154~160 (1987)
  53. "Meta-analysis of P300 normative aging studies", 33, pp.334~353 (1996)
  54. "Increased rate of P300 latency with age in schizophrenia:electrophysiological evidence for neurodegenerative process", 52, pp.544~549 (1995)

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