정신분열병의 임상적 고위험군의 특징 : '서울청년클리닉'의 자연 추적 관찰 에비연구
Characteristics of Subjects at Clinical High Risk for Schizophrenia : Natural Follow up Study in 'Seoul Youth Clinic' - Pilot Study
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참고문헌
초록
본 연구는 청년클리닉의 운영 현황을 임상적 고위험군을 대상으로 고찰해 봄으로써 실제 임상에서 장기적인 추적 관찰 연구가 갖는 문제점들을 도출할 수 있었다. 또한, 임상적 고위험군이 갖는 임상적 특징을 살펴보았고, 인지, 사회, 정서 기능의 일부 항목이 정상인에 비해 저하되어 있음을 확인할 수 있었다. 이런 결과들에도 불구하고 본 연구는 아직 대상자들의 수와 추적 기간의 제한으로 인해 임상적 고위험군의 경과 와 정신분열병의 예측 인자를 논하기에는 한계가 있다. 하지만, 향후 장기적인 추적연구를 통하여 정신분열병으로 전환되는 대상자들이 가지는 특징들에 대한 고찰을 하기 위한 초석을 제공하고, 발병 예측 인자들을 규명하는 노력의 시작으로서 이번 연구의 의미를 찾을 수 있을 것이다.
Abstract
Objectives：The aims of this study were to identify the intake and following process for subjects at high risk of transition to schizophrenia and to examine the neurocognitive, social, and emotional functions of the subjects compared with healthy controls. Methods：Symptomatic individuals judged at high risk for schizophrenia (‘clinical high risk’) within Youth Clinic were assessed and followed up. They performed a neurocognitive function test, a social function test and an affective function test. Twenty healthy controls were recruited in this study. Results：Among eighty-two subjects contacted through the Youth clinic, sixteen subjects were judged as the clinical high risk group. Fourteen subjects among the clinical high risk group showed deficits in several domains of neurocognitive functions, such as visual recall memory, verbal short term memory and executive function. Social and affective functions are also impaired in the clinical high risk group compared with healthy controls. Two of 15 subjects (13%) developed a psychotic disorder within 6 months. Conclusion：This study illustrates the state of follow-up study for a clinical high risk group. Despite low numbers and short durations, some impairment of several functions in the clinical high risk group suggests possible predictors of psychosis. (J Korean Neuropsychiatr Assoc 2007;46(1):19-28)
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