임신 중기 및 초기 소아기 간접 흡연 노출과 Glutathione S-Transferase 유전자 다형성이 소아행동발달에 미치는 영향
The Effect of Environmental Tobacco Smoke Exposure and Glutathione S-Transferase Polymorphism on Childhood Behavioral Development during Mid-Pregnancy and Early Childhood
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Objectives The author investigated the relationship between the environmental tobacco smoke exposure during mid-pregnancy and early childhood and neurobehavioral outcomes of preschool children and if there is any effect of the genetic polymorphism of glutathione S-transferase (GST) M1 and T1 on this relationship. Methods The participants were the pregnant women (week 24-28) who visited the obstetrics and gynecology department (between 2001 and 2004). They had been evaluated for their sociodemographic data including direct and environmental tobacco smoke exposure history and the urine specimen had been sampled for the measurement of cotinine. The offsprings’ urine specimen and blood sampling had been done and the socioeconomic data including the environmental tobacco smoke exposure history was evaluated at age 3. The cotinine level of urine specimen was measured and GST polymorphism was analyzed. The offsprings completed Korean-Childhood Behavioral Check List (K-CBCL) at age 4-5. Results The environmental tobacco smoke exposure during mid-pregnancy based on urine cotinine level has a significant association with increased total score and externalizing problem score of K-CBCL (p<0.05). The environmental tobacco smoke exposure based on urine cotinine level at age 3 is associated increased total score, externalizing problem score and internalizing problem score of K-CBCL with no statistical significance. The environmental tobacco smoke exposure after controlling for tobacco smoke exposure during pregnancy, however, is significantly associated with the increased externalizing problem scores (p=0.04). The environmental tobacco smoke exposure is associated with increased total score, externalizing problem score and internalizing problem score of K-CBCL with GSTM1 null type or GSTT1 null type at age 3 although there was no statistical significance. Conclusion The environmental tobacco smoking exposure during pregnancy and at early childhood is associated with childhood behavioral problems. The clinical implication of this study is that it is important to avoid the environmental tobacco smoke exposure during pregnancy and early childhood and to monitor the possible emergence of behavioral problems of children.
Abstract
Objectives The author investigated the relationship between the environmental tobacco smoke exposure during mid-pregnancy and early childhood and neurobehavioral outcomes of preschool children and if there is any effect of the genetic polymorphism of glutathione S-transferase (GST) M1 and T1 on this relationship. Methods The participants were the pregnant women (week 24-28) who visited the obstetrics and gynecology department (between 2001 and 2004). They had been evaluated for their sociodemographic data including direct and environmental tobacco smoke exposure history and the urine specimen had been sampled for the measurement of cotinine. The offsprings’ urine specimen and blood sampling had been done and the socioeconomic data including the environmental tobacco smoke exposure history was evaluated at age 3. The cotinine level of urine specimen was measured and GST polymorphism was analyzed. The offsprings completed Korean-Childhood Behavioral Check List (K-CBCL) at age 4-5. Results The environmental tobacco smoke exposure during mid-pregnancy based on urine cotinine level has a significant association with increased total score and externalizing problem score of K-CBCL (p<0.05). The environmental tobacco smoke exposure based on urine cotinine level at age 3 is associated increased total score, externalizing problem score and internalizing problem score of K-CBCL with no statistical significance. The environmental tobacco smoke exposure after controlling for tobacco smoke exposure during pregnancy, however, is significantly associated with the increased externalizing problem scores (p=0.04). The environmental tobacco smoke exposure is associated with increased total score, externalizing problem score and internalizing problem score of K-CBCL with GSTM1 null type or GSTT1 null type at age 3 although there was no statistical significance. Conclusion The environmental tobacco smoking exposure during pregnancy and at early childhood is associated with childhood behavioral problems. The clinical implication of this study is that it is important to avoid the environmental tobacco smoke exposure during pregnancy and early childhood and to monitor the possible emergence of behavioral problems of children.
참고문헌 (35)
- Batstra L, "Effect of antenatal exposure to maternal smoking on behavioural problems and academic achievement in childhood: prospective evidence from a Dutch birth cohort", Early Hum Dev, 75, pp.21~33 (2003)
- Kollins SH, "Effects of postnatal parental smoking on parent and teacher ratings of ADHD and oppositional symptoms", J Nerv Ment Dis, 197, pp.442~449 (2009)
- Twardella D, "GME Study Group. Exposure to secondhand tobacco smoke and child behaviour - results from a cross-sectional study among preschool children in Bavaria", Acta Paediatr, 99, pp.106~111 (2010)
- Rückinger S, "Prenatal and postnatal tobacco exposure and behavioral problems in 10-year-old children: results from the GINI-plus prospective birth cohort study", Environ Health Perspect, 118, pp.150~154 (2010)
- Anderko L, "Contribution of tobacco smoke exposure to learning disabilities", J Obstet Gynecol Neonatal Nurs, 39, pp.111~117 (2010)
- Williams GM, "Maternal cigarette smoking and child psychiatric morbidity: a longitudinal study", Pediatrics, 102, pp.11~ (1998)
- Gatzke-Kopp LM, "Direct and passive prenatal nicotine exposure and the development of externalizing psychopathology", Child Psychiatry Hum Dev, 38, pp.255~269 (2007)
- Robinson M, "Pre- and postnatal influences on preschool mental health: a largescale cohort study", J Child Psychol Psychiatry, 49, pp.1118~1128 (2008)
- Thapar A, "Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptoms in offspring", Am J Psychiatry, 160, pp.1985~1989 (2003)
- Obel C, "Smoking during pregnancy and hyperactivity-inattention in the offspring--comparing results from three Nordic cohorts", Int J Epidemiol, 38, pp.698~705 (2009)
- Boutwell BB, "Maternal cigarette smoking during pregnancy and offspring externalizing behavioral problems: a propensity score matching analysis", Int J Environ Res Public Health, 7, pp.146~163 (2010)
- Thapar A, "Prenatal smoking might not cause attention-deficit", hyperactivity disorder: evidence from a novel design, 2009, pp.66, 722~727
- Knopik VS, "Maternal smoking during pregnancy and child outcomes: real or spurious effect", Dev Neuropsychol, 34, pp.1~36 (2009)
- Hong YC, "Genetic susceptibility of term pregnant women to oxidative damage", Toxicol Lett, 129, pp.255~262 (2002)
- 박은주, "Glutathione S-Transferase 유전적 다형성이 항산화 체계에 미치는 영향", 한국식품영양과학회지, 36(6), pp.708~719 (2007), 한국식품영양과학회
- "Maternal exposure to environmental tobacco smoke, GSTM1", T1 polymorphisms and oxidative stress, 2008, pp.26, 197~202[DOI]
- Hsieh CJ, "CYP1A1 Ile462Val and GSTT1 modify the effect of cord blood cotinine on neurodevelopment at 2 years of age", Neurotoxicology, 29, pp.839~845 (2008)
- 이혜령, "간접흡연에 노출된 청소년의 요 코티닌 배설량", Korean Journal of Family Medicine, 30(1), pp.31~38 (2009), 대한가정의학회
- George L, "Self-reported nicotine exposure and plasma levels of cotinine in early and late pregnancy", Acta Obstet Gynecol Scand, 85, pp.1331~1337 (2006)
- Haufroid V, "Urinary cotinine as a tobacco-smoke exposure index: a minireview", Int Arch Occup Environ Health, 71, pp.162~168 (1998)
- 강윤희, "흡연자 선별을 위한 요중 코티닌 검사의 유용성", Annals of Laboratory Medicine, 23(2), pp.92~97 (2003), 대한진단검사의학회
- Hong YC, "Effects of the GSTM1 and GSTT1 polymorphisms on the relationship between maternal exposure to environmental tobacco smoke and neonatal birth weight", J Occup Environ Med, 45, pp.492~498 (2003)
- 4-18 and 1991 Profile, "Manual for the Child Behavior Check List", pp.1991, Achenbach TM
- Oh KJ, "Development of Korean Child Behavior checklist: a preliminary study", J Korean Neuropsychiatr Assoc, 29, pp.452~462 (1990)
- Lee H, "Clinical validity study of Korean CBCL through item analysis", Korean J Child & Adol Psychiatr, 2, pp.138~149 (1991)
- Achenbach TM, "Empirically based assessment of child and adolescent psychopathology (2nd end)" (1997), Thousand Oaks: Sage Publications
- 김붕년, "주의력결핍", 과잉행동 증상에 연관된 임신, 분만 및 주산기 위험 요인에 관한 연구 -지역사회 연구-, 2002, pp.41(2), ~[DOI]
- Fagnano M, "Environmental tobacco smoke and behaviors of inner-city children with asthma", Ambul Pediatr, 8, pp.288~293 (2008)
- Yolton K, "Environmental tobacco smoke exposure and child behaviors", J Dev Behav Pediatr, 29, pp.450~457 (2008)
- Muneoka K, "Nicotine exposure during pregnancy is a factor which influences serotonin transporter density in the rat brain", Eur J Pharmacol, 411, pp.279~282 (2001)
- Fergusson DM, "Maternal smoking before and after pregnancy: effects on behavioral outcomes in middle childhood", Pediatrics, 92, pp.815~822 (1993)
- Wasserman GA, "Contribution of maternal smoking during pregnancy and lead exposure to early child behavior problems", Neurotoxicol Teratol, 23, pp.13~21 (2001)
- Maughan B, "Pregnancy smoking and childhood conduct problems: a causal association", J Child Psychol Psychiatry, 42, pp.1021~1028 (2001)
- 박은주, "Glutathione S-Transferase M1 and T1 Polymorphisms and Susceptibility to Oxidative Damage in Healthy Korean Smokers", ANNALS OF NUTRITION AND METABOLISM, 56, pp.52~58 (2010), KARGER
- Morales E, "GSTM1 polymorphisms modify the effect of maternal smoking during pregnancy on cognitive functioning in preschoolers", Int J Epidemiol, 38, pp.690~697 (2009)