소아 만성 두드러기의 원인과 경과에 관한 임상적 고찰
Chronic Urticaria in Childhood : Etiology and Outcome
2
조회
0
다운로드
7
인용
0
참고문헌
초록
목 적 : 소아에서 만성 두드러기의 원인과 경과를 알아보았다. 만성 두드러기의 예후에 영향을 주는 인자들을 살펴보았고, 만성 특발성 두드러기에서 자가면역 두드러기의 진단을 위한 ASST의 임상적 의의를 알아보고자 하였다.방 법 : 6주 이상 두드러기가 지속되었던 만성 두드러기 환아 39명의 검사 결과와 임상 양상을 후향적으로 조사하였다. 만성 두드러기의 완해율에 영향을 미치는 임상적인 요인을 고찰하고, ASST의 양성군과 음성군의 임상 양상을 비교하였다.
Abstract
Purpose : The aim of this study was to evaluate the etiology and outcome of chronic urticaria (CU) in childhood. Methods : We reviewed retrospectively the clinical manifestations and laboratory findings of the thirty-nine patients with urticaria and/or angioedema for more than 6 weeks. We also invested the clinical parameters affecting the remission. Positive autologous serum skin test (ASST) results were compared with CU remission. Results : Male occupied about 56.4% of patients (n=22). Age at first outpatient clinic visit was from 12 month to 13 years 9 month. Duration of symptoms before visit were from 6 weeks to 6 months. Among the etiologic causes, 35.9% (n=14) of patients had physical urticaria, concretely, 17.9% (n=7) of patients had cold urticaria, 12.8% (n=5) of patients had symptomatic dermographism, 5.1% (n=2) of patients had cholinergic urticaria. Sinusitis was associated with CU in 5.1% (n=2) of patients. Unknown causes were 59.9% (n=23) of patients, and among them, 34.8% (n=8) of patients had positive ASST. Disease remission was observed in 56.4% (n=22), but non-remission was observed in 43.6% (n=17). Remission of CU was not associated with age, gender, etiology, and ASST. The remission rate of ASST negative group was higher than the ASST positive group, but it was not significant statistically. Conclusion : Etiologies of CU were variable and physical urticaria should be evaluated first. Unknown etiology were 59.9% and of them, correlation positive ASST with disease remission rate should be evaluated later with further study.
참고문헌 (19)
- "Chronic urticaria in children", 26, pp.13~17 (2005)
- "Chronic urticaria in childhood", 55, pp.309~320 (2000)
- "Drug eruption, erythema and urticaria", pp.213~220 (2001), Kyo moon gark
- "Etiologic factors in childhood chronic urticaria", nakis m, pp.61~5
- "Chronic urticaria: association with thyroid autoimmunity", 88, pp.517~519 (2003)
- "Chronic urticaria", 64, pp.2515~2536 (2004)
- "High prevalence of autoimmune urticaria in children with chronic urticaria", 114, pp.922~927 (2004)
- "Serum IgE levels in healthy children quantified by a sandwich technique", pp.51~9
- "Chronic urticaria and infections", 4, pp.387~396 (2004)
- "Helicobacter pylori infection and chronic urticaria", 34, pp.685~686 (1996)
- "A prospective study for the prevalence of Helicobacter pylori infection in patients with chronic urticaria in Korea", 36, pp.1005~1011 (1998)
- "Chronic idiopathic urticaria and thyroid autoimmunity: a second opinion", 107, pp.S51~ (2001)
- "Joint Task Force on Practice Parameters. The diagnosis and management of urticaria: a practice paramenter. Part Ⅰ: Acute urticaria", angioedema. Part Ⅱ: Chronic urticaria, pp.2000, 85[DOI]
- "Intravenous immunoglobulin in autoimmune chronic urticaria", 138, pp.101~106 (1998)
- "Chronic idiopathic urticaria: comparison of the clinical features of patients with and without anti-Fc RI or anti-IgE autoantibodies", 40, pp.443~450 (1999)
- "Autoantibodies to the high-affinity IgE receptor in children with chronic urticaria", 96, pp.341~344 (2006)
- "Successful treatment of chronic idiopathic urticaria associated with thyroid autoimmunity", 10, pp.342~345 (2000)
- "Clinical and laboratory parameters in predicting chronic urticaria duration: a prospective study of 139 patients", 59, pp.869~873 (2004)
- "The autologous serum skin test in the follow-up of patients with chronic urticaria", 60, pp.256~258 (2005)