노인 남성에서 체위성 폐쇄성수면무호흡증 환자와 비체위성 폐쇄성수면무호흡증 환자의 인지기능 비교
Comparison of Neurocognitive Functions between Positional Obstructive Sleep Apnea Patients and Non-Positional Obstructive Sleep Apnea Patients in the Korean Elderly Population
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초록
Objectives Obstructive sleep apnea (OSA) is classified as positional sleep apnea (POSA) and non-positional sleep apnea (NPOSA) according to apnea-hypopnea index (AHI) changed by sleep position. The aim of this study was to compare neurocognitive functions between two groups in the elderly Korean population. Methods Forty-four subjects in OSA patients with total AHI≥5 participated as criteria for POSA (n=25) with 1) supine position AHI/non-supine position AHI≥2 and 2) total AHI≥5 or not (NPOSA, n=19). All participants completed clinical interview by physician and neurocognitive function as¬sessments. Mann-Whitney U and chi-square test were performed for comparison of neurocogni¬tive functions and sleep characteristics with polysomnography between two groups. Results No significant difference in demographic and clinical characteristics was observed be¬tween the two groups. However the NPOSA group showed more decline than the POSA group on the Boston naming test (p=0.034), digit span test (p=0.001), go-no-go test (p=0.042), and fist-edge-palm test (p=0.007). Conclusion In this study NPOSA patients were found to have lower cognitive functions com¬pared to POSA patients. A larger sample and long term follow-up study might be needed.
Abstract
Objectives Obstructive sleep apnea (OSA) is classified as positional sleep apnea (POSA) and non-positional sleep apnea (NPOSA) according to apnea-hypopnea index (AHI) changed by sleep position. The aim of this study was to compare neurocognitive functions between two groups in the elderly Korean population. Methods Forty-four subjects in OSA patients with total AHI≥5 participated as criteria for POSA (n=25) with 1) supine position AHI/non-supine position AHI≥2 and 2) total AHI≥5 or not (NPOSA, n=19). All participants completed clinical interview by physician and neurocognitive function as¬sessments. Mann-Whitney U and chi-square test were performed for comparison of neurocogni¬tive functions and sleep characteristics with polysomnography between two groups. Results No significant difference in demographic and clinical characteristics was observed be¬tween the two groups. However the NPOSA group showed more decline than the POSA group on the Boston naming test (p=0.034), digit span test (p=0.001), go-no-go test (p=0.042), and fist-edge-palm test (p=0.007). Conclusion In this study NPOSA patients were found to have lower cognitive functions com¬pared to POSA patients. A larger sample and long term follow-up study might be needed.
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