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정신분열병에서 결핍증후군의 진단적 안정성 평가 : 5년간 추적 조사

Stability of the Diagnosis of Deficit Syndrome in Shcizophrenia : A 5-year Follow-up Study

홍경수|이동수|최경숙|박동연
대한신경정신의학회 (Korean Neuropsychiatric Association)|2004.05|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제43권 제3호|pp. 296-302

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참고문헌

키워드

정신분열병 · 결핍증후군 · 진단적 안정성.Schizophrenia · Deficit syndrome · Diagnostic stability.
주제분류정신과학

초록

Abstract

Objectives：Primary, enduring negative symptoms have been used to define the deficit syndrome of schizophrenia, and the diagnostic validity of the deficit syndrome has been demonstrated by clinical, biological and neuropsychological studies. This study aims at evaluating the long-term stability of the diagnostic category of deficit syndrome using direct patient assessments. Methods：The subjects were thirty-two patients with schizophrenia who were categorized into deficit or non-deficit subgroup using the Schedule for the Deficit Syndrome (SDS) in their remission or partial remission state maintained by long-term treatments with antipsychotics (mostly atypical drugs). These patients were re-assessed based on the same deficit syndrome criteria an average of 5.6 years after having been initially categorized. Lifetime presence of clinical symptoms were evaluated using the Krawiecka Scale. Results：The majority (87.5%) of the patients who were classified as non-deficit at the initial assessment continued to remain non-deficit during the follow-through period. However, only 37.5% of the patients classified as deficit at the initial assessment remain classified as showing deficit syndrome. Compared to the non-deficit group, patients of the deficit group at the final assessment showed significantly higher scores of positive symptoms at their previous psychotic states. Among the individual items of SDS, ‘poverty of speech’ was the most predictable of the long-lasting deficit syndrome. Conclusion：This study showed insufficient long-term stability of the deficit syndrome categorized by SDS criteria. This could be explained by low validity of SDS criteria for the identification of the trait-dependent deficit syndrome. It might also suggest that deficit symptoms could be improved by optimal long-term treatment with atypical antipsychotics. (J Korean Neuropsychiatr Assoc 2004;43(3):296-302)

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