Capsaicin 투여가 C57BL/6형 생쥐의 알코올 섭취량에 미치는 영향
Effect of Capsaicin on Alcohol Intake in C57BL/6 Mice
0
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
Abstract
Objectives：Capsaicin, the pungent analgesic substance of the red pepper, is known to affect central opioid activities, which is one of the most important factors to alcohol intake behavior. The purpose of this study was to investigate whether systemic administration of capsaicin affects alcohol intake in C57BL/6 mice. Methods：After intraperitoneal administration of 0.01 mg/kg of capsaicin with a vehicle or the vehicle alone as the control for eight days in C57BL/6 mice on a limited access alcohol model, capsaicin’s effects on 2-hour alcohol, 22-hour water, 24-hour food intake and body weight were studied. Results：1) For 2-hour alcohol intake, a repeated measures ANOVA (2 drug treatment groups repeated across 5 two-day blocks) yielded a significant group by block interaction (p<0.05). The independent t-test showed that significant suppression of 2-hour alcohol intake was observed when subjects were administered with capsaicin compared with the vehicle alone across the last three 2-day blocks (p<0.05). The paired t-test revealed that significant suppression of 2-hour alcohol intake was observed when subjects were administered with capsaicin compared with before capsaicin administration across the last two 2-day blocks (p<0.01). But there is no significant difference of 2-hour alcohol intake when subjects were administered with the vehicle alone compared with before vehicle administration. 2) A repeated measures ANOVA revealed no significant group by block interaction for 22-hour water intake, 24-hour food intake, or body weight. Conclusion：These results show that capsaicin administration can affect alcohol intake behavior and also suggest that food culture might affect drinking behaviors. (J Korean Neuropsychiatr Assoc 2004;43(5):564-569)
참고문헌 (19)
- "Capsaicin:cellular targets,mechanisms of action,and selectivityfor thin sensory neurons", 43, pp.143~201 (1991)
- "Vanilloid (capsaicin) receptors in health and disease", 118, pp.110~121 (2002)
- "Vanilloid(Capsaicin)receptors andmechanisms", 51, pp.159~212 (1999)
- "Cerebrospinal fluid β-endorphin in models of hyperalgesia in the rat", 59, pp.79~86 (1995)
- "Release of beta-endorphin immunoreactivityinto ventriculo-cisternal perfusate by lumbar intrathecal capsaicin inthe rat", 701, pp.192~200 (1995)
- "Capsaicin decreasesB-endorphin hypothalamic concentrations in the rat", 15, pp.825~832 (1983)
- "Morphine or capsaicin administrationalters the secretion of beta-endorphin into the hypophysialportal vasculature of the rat", 43, pp.611~617 (1986)
- "Persistence and specificity of smalldoses of morphine on intake of alcoholic beverages", 4, pp.149~156 (1987)
- "Modulation of ethanol-intake by morphine:evidencefor a central site of action", 47, pp.~54 (1990)
- "Naltrexone persistently reducesrats’ intake of a palatable alcoholic beverage", 20, pp.584~588 (1996)
- "Central administrationof an opiate antagonist decreases oral ethanol self-administration inrats", 23, pp.1468~1476 (1999)
- "Benzodiazepine receptor ligandsmodulate ethanol drinking in alcohol-preferring rats", 263, pp.141~147
- "Implications of endogenous opioids and dopamine inalcoholism:human and basic science studies", 31, pp.33~42 (1996)
- "Naltrexone과 acamprosate의 장기간 병합 투여가 C57BL", 6형 생쥐의 알코올 섭취량에 미치는영향, 2001, pp.40, 981~990
- "Differential effects ofcapsaicin on the content of somatostatin,substance P,and neurotensinin the nervous system of the rat", 317, pp.140~148
- "Pain-induced analgesia mediated bymesolimbic reward circuits", 19, pp.7175~7181 (1999)
- "Altered nucleus accumbens circuitry mediates pain-induced antinociceptionin orphine-tolerant rats", 22, pp.6773~6780 (2002)
- "Endogenous opioids and addiction to alcohol and otherdrugs of abuse", 4, pp.39~50 (2004)
- "The role of dopamine in the nucleus accumbensin analgesia", 65, pp.2269~2287 (1999)