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알코올 사용 장애의 약물 치료

Pharmacotherapy of Alcohol Use Disorders

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대한신경정신의학회 (Korean Neuropsychiatric Association)|2004.11|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제43권 제6호|pp. 652-658

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참고문헌

키워드

알코올 사용장애 ·약물치료.Alcohol dependence · Pharmacotherapy.
주제분류정신과학

초록

Abstract

Alcoholism, a major public health problem throughout the world, causes enormous damage to health and quality of life and undermines the well-being of families and society. It is associated with liver disease, cancer, cardiovascular problems, accidental deaths, suicides, and homicides. Over the last 20 years, rational drug treatment have arisen from better understanding of the neurobiological substrates of alcohol dependence, including adaptive changes in amino acid neurotransmitter systems, stimulation of dopamine and opioid peptide systems, and, possibly, changes in serotonergic activity. Disulfiram, naltrexone and acamprosate are currently the only treatments approved for the management of alcohol dependence. Data from studies of ondansetron and topiramate in alcohol dependence are somewhat promising, but it appears that these drugs have not yet demonstrated evidence of efficacy in large controlled clinical trials. Trials with SSRIs and some antipsychotics have yielded disappointing results. Because the biological basis of alcohol dependence appears to be multifactorial, the future of management of alcoholism may be combination therapy, using drugs acting on different neuronal pathways, such as acamprosate and naltrexone. Pharmacotherapy should be used in association with appropriate psychosocial support and specific treatment provided for any underlying psychiatric comorbidities. (J Korean Neuropsychiatr Assoc 2004;43(6):652-658)

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관련 논문AI추천

알코올 사용 장애의 최신 지견남궁기대한신경정신의학회 · 신경정신의학2004 · 제43권 제6호외래에서 알코올사용장애를 어떻게 치료할 것인가?정영철대한신경정신의학회 · 신경정신의학2019 · 제58권 제3호알코올 의존에 대한 최근 정신사회 치료적 접근기선완대한신경정신의학회 · 신경정신의학2004 · 제43권 제6호알코올 사용 장애의 최신지견 : 여성 알코올 사용 장애의 특징 및 치료이은대한신경정신의학회 · 신경정신의학2004 · 제43권 제6호정신병적 장애의 정신약물치료이상희, 정성훈대한생물치료정신의학회 · 생물치료정신의학1996 · 제2권 제1호알코올 금단 증상의 치료에서 Topiramate의 효과 및 안전성기선완, 김성은, 김지웅, 박진균, 최은애대한신경정신의학회 · 신경정신의학2005 · 제44권 제3호

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