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한국인 알코올 의존 환자에서 알코올 대사 효소 유전자형 빈도의 남녀 차이

Gender Differences in Alcohol Metabolizing Hepatic Enzyme Genotypes in Korean Patients with Alcohol Dependence

이현숙|김철민|김성연|박제민|최병무|이덕기|황인복|김명정|김성곤|송영상|전은숙
대한신경정신의학회 (Korean Neuropsychiatric Association)|2005.03|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제44권 제2호|pp. 221-231

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참고문헌

주제분류정신과학

초록

Abstract

Objectives：There are a number of preceding epidemiological studies reporting gender differences in the genetic etiology of alcohol dependence. The author investigated gender difference in the frequencies of ADH2 and ALDH2 genoypes between the patients with alcohol dependence and normal control. Methods：The subjects were 141 alcohol dependent patients (104 males, 37 females) and 138 normal control (79 males, 59 females). The frequencies of 1/1 and 1/2+2/2 (2+ afterward) genotypes for ADH2 and ALDH2 were investigated in male and female between alcohol dependence and normal control group. DNA was extracted from WBC in peripheral venous blood and PCR-RFLP method was used out for genotyping. Results：First, the frequency of ADH2 1/1 genotype was significantly higher in alcohol dependent patients than normal control in both genders. Second, while there was no gender difference in the frequency of ADH2 1/1 genotype in normal controls, in the patient group however, the frequency was significantly higher in females than males. Third, in male subjects with alcohol dependence, the frequency of ALDH2 1/1 genotype was significantly higher than in male normal control subjects. On the other hand, in female subjects with alcohol dependence, the frequency of ALDH2 2+ genotype was significantly higher than in female normal control subjects. Conclusion：These results suggest that while the risk of alcohol dependence is predominantly affected by ALDH2 1/1 genotype in male, the female ADH2 1/1 genotype is mainly associated with the risk of alcohol dependence. This means that there are gender differences in the genetic etiology of alcohol dependence.

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관련 논문AI추천

알코올의존 환자의 Aldehyde Dehydrogenase 2 유전자 변이에 따른 음주양상 및 성격특성김석현, 남정현, 노성원, 양병환, 이정식, 이종일, 조성남, 채영규, 최인근대한생물정신의학회 · 생물정신의학2005 · 제12권 제2호한국인 남녀 알코올 의존 환자에서의 알코올 대사 효소 유전자 다형성에 관한 연구강철중, 김성곤, 김현경, 변원탄, 황인복대한생물치료정신의학회 · 생물치료정신의학2006 · 제12권 제1호한국인에서 알코올 의존과 μ 아편계 수용체 유전자 다형성의 연관성에 관한 연구김성곤대한신경정신의학회 · 신경정신의학2003 · 제42권 제5호한국인 집단에서 알코올 의존과 세로토닌 수송체 유전자 다형성의 연관성구준, 김봉조, 노양덕, 박철수, 손진옥, 이철순, 한규희대한생물치료정신의학회 · 생물치료정신의학2007 · 제13권 제2호ADH1B와 ALDH2 활성 조합이 젊은 한국인의 음주 행동에 미치는 영향김시경, 박재영, 이상익대한생물정신의학회 · 생물정신의학2010 · 제17권 제1호알코올 의존 환자의 Tryptophan Hydroxylase 유전자 다형성김헌, 신철진, 이상익, 정인원, 지경환, 홍주봉대한신경정신의학회 · 신경정신의학2001 · 제40권 제4호

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