노년기 주관적 기억력 감퇴의 예측인자 : 한국인의 건강과 노화에 관한 종적 연구 결과
Predictors for Subjective Memory Complaints in the Elderly : The Results from Korean Longitudinal Study on Health and Aging (KLoSHA)
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초록
고학력의 정상 노인에서 타인에 비해 자신의 기억력이 나쁘다고 호소하는 주관적 기억감퇴는 경미한 우울감이나 전두엽 기능 저하에 대한 예민한 주관적 지각일 가능성이 높으므로, 적극적인 진단 평가와 지속적인 추적 관찰이 요구된다.
Abstract
Objectives:We investigated the predictors of subjective memory complaints in the community-dwelling normal elderly. Methods:This study was conducted as a part of Korean Longitudinal Study on Health and Aging (KLoSHA). 747 nondemented community-dwelling elderly aged 65 years or older were recruited. All participants underwent clinical evaluation for dementia and psychiatric disorder conformed to the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD-K) Clinical Assessment Battery and Korean version of Mini-International Neuropsychiatric Interview, respectively. Word list recall test, frontal assessment battery, Mini Mental Status Examination (MMSE-KC) and Korean version of Geriatric depression scale (GDS-K) were administered to evaluate episodic memory, frontal function, global cognition and depression, respectively. Subjective memory complaint was defined in two different ways: worse than one’s past (SMC-P) and worse than others of one’s age (SMC-O). Results:In highly educated elderly, minor depressive disorder (OR=7.23, 95% C.I.= 2.29-22.86) and frontal dysfunction (OR=2.48, 95% C.I.=1.29-4.77) significantly increased the risk of SMC-O. However, they did not influence the risk of SMC-P. In low educated elderly, both the minor depressive disorder and frontal dysfunction did not influence the risk of SMCO as well as that of SMC-P. Conclusion:SMC-O can be a sensitive subjective recognition of mild depression and/or frontal dysfunction in highly educated normal elderly. (J Korean Neuropsychiatr Assoc 2007;46(6):560-565)
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