본문 바로가기
KERD
논문

한국 소아 아나필락시스의 연구 현황과 과제

The past, present, and future of research on anaphylaxis in Korean children

이수영
pp. 21-30|DOI https://doi.org/10.4168/aard.2018.6.S1.S21

0

조회

0

다운로드

2

인용

0

참고문헌

키워드

HospitalChildhoodPopulationAnaphylaxisProspective registry
주제분류소아과학

초록

Anaphylaxis is a serious, life-threatening hypersensitivity reaction that is rapid in onset and might cause death when not treated promptly. Recently, the prevalence of anaphylaxis has been increasing worldwide, especially in children, and food-induced anaphylaxis is rapidly increasing. With the establishment of the Korean Academy of Pediatric Allergy and Respiratory Disease in 1987, awareness of anaphylaxis has been heightened in Korea as well. Initially, it was considered a clinical form of food or drug hypersensitivity, but not a single disease entity. After the second symposium on anaphylaxis in 2006 and the World Allergy Organization guideline on anaphylaxis in 2011, research more focused on anaphylaxis is ongoing. The study of anaphylaxis in Korean children was initially restricted to case reports due to novel triggers. Thereafter, research on the age-specific prevalence of anaphylaxis was conducted using the national big data and more recently, a large-scale hospital-based multicenter study was conducted. Also, reliable data on food-induced anaphylaxis have been attained through a large-scale multicenter case study and a population-based epidemiological study on food allergy and currently, a prospective multicenter anaphylaxis registry has been launched funded by Korea Centers for Disease Control and Prevention. These series of studies have contributed to the international competitiveness in pediatric anaphylaxis research. However, there are still unmet needs such as diagnosis, severity, treatment or intervention of anaphylaxis, education for the prevention of recurrence, and establishment of policies for social safety. Further studies addressing these issues will contribute to improvement of quality of life and overcoming of the disease.

Abstract

Anaphylaxis is a serious, life-threatening hypersensitivity reaction that is rapid in onset and might cause death when not treated promptly. Recently, the prevalence of anaphylaxis has been increasing worldwide, especially in children, and food-induced anaphylaxis is rapidly increasing. With the establishment of the Korean Academy of Pediatric Allergy and Respiratory Disease in 1987, awareness of anaphylaxis has been heightened in Korea as well. Initially, it was considered a clinical form of food or drug hypersensitivity, but not a single disease entity. After the second symposium on anaphylaxis in 2006 and the World Allergy Organization guideline on anaphylaxis in 2011, research more focused on anaphylaxis is ongoing. The study of anaphylaxis in Korean children was initially restricted to case reports due to novel triggers. Thereafter, research on the age-specific prevalence of anaphylaxis was conducted using the national big data and more recently, a large-scale hospital-based multicenter study was conducted. Also, reliable data on food-induced anaphylaxis have been attained through a large-scale multicenter case study and a population-based epidemiological study on food allergy and currently, a prospective multicenter anaphylaxis registry has been launched funded by Korea Centers for Disease Control and Prevention. These series of studies have contributed to the international competitiveness in pediatric anaphylaxis research. However, there are still unmet needs such as diagnosis, severity, treatment or intervention of anaphylaxis, education for the prevention of recurrence, and establishment of policies for social safety. Further studies addressing these issues will contribute to improvement of quality of life and overcoming of the disease.

참고문헌 (63)

  1. 이수영, "아나필락시스: 역학과 임상적 중요성", Allergy Asthma & Respiratory Disease, 22(3), pp.215~218 (2012), 대한 소아알레르기 호흡기학회
  2. Sampson HA, "Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease", Food Allergy and Anaphylaxis Network symposium, 2006, pp.117, 391~397
  3. Lee S, "A nation-wide survey on anaphylaxis in Korea and preliminaries for Korean surveillance system" (2016)
  4. Yocum MW, "Epidemiology of anaphylaxis in Olmsted County: a population-based study", J Allergy Clin Immunol, 104(2 Pt 1), pp.452~456 (1999)[DOI]
  5. Bohlke K, "Epidemiology of anaphylaxis among children and adolescents enrolled in a health maintenance organization", J Allergy Clin Immunol, 113, pp.536~542 (2004)[DOI]
  6. Decker WW, "The etiology and incidence of anaphylaxis in Rochester, Minnesota: a report from the Rochester Epidemiology Project", J Allergy Clin Immunol, 122, pp.1161~1165 (2008)[DOI]
  7. Sorensen HT, "Anaphylactic shock occurring outside hospitals", Allergy, 44, pp.288~290 (1989)[DOI]
  8. Huang F, "Anaphylaxis in a New York City pediatric emergency department: triggers, treatments, and outcomes", J Allergy Clin Immunol, 129, pp.162~168 (2012)[DOI]
  9. Gil SY, "A case of anaphylaxis after ingestion of pup", Allergy (Korea), 3, pp.175~178 (1983)
  10. Simons FE, "World Allergy Organization anaphylaxis guidelines: summary", J Allergy Clin Immunol, 127, pp.587~593 (2011)[DOI]
  11. Lee KY, "Immediate type reaction of food allergy confirmed by open food challenge test: diagnostic value of history and skin test in food allergy", Pediatr Allergy Respir Dis, 7, pp.173~186 (1997)
  12. 최완석, "소아에서 발생한 카레 가루에 대한 아나필락시스 1례", Allergy Asthma & Respiratory Disease, 15(2), pp.170~173 (2005), 대한 소아알레르기 호흡기학회
  13. 이정민, "영아 이유식에 의해 발생한 보리 아나필락시스 1례", Allergy Asthma & Respiratory Disease, 20(4), pp.297~301 (2010), 대한 소아알레르기 호흡기학회
  14. 김희수, "식품 경구유발시험으로 진단한 닭고기 아나필락시스 1례", Allergy Asthma & Respiratory Disease, 21(3), pp.234~237 (2011), 대한 소아알레르기 호흡기학회
  15. 방성준, "돼지고기에 감작된 환아에서 발생한 돼지고기 의존성 운동 유발성 아나필락시스 1례", Allergy Asthma & Respiratory Disease, 22(1), pp.116~121 (2012), 대한 소아알레르기 호흡기학회[DOI]
  16. 최진화, "홍삼 제품 내 식물 성분 의존성 운동유발성 아나필락시스 1예", Allergy Asthma & Respiratory Disease, 3(3), pp.219~223 (2015), 대한 소아알레르기 호흡기학회
  17. 김어진, "모유 수유아에서 발생한 계란 흰자 피부접촉에 의한 아나필락시스 쇽 1례", Pediatric Gastroenterology, Hepatology & Nutrition, 7(1), pp.83~86 (2004), 대한소아소화기영양학회
  18. 송지은, "2세 남아에서 발견된 들깨 알레르기 1례", Allergy Asthma & Respiratory Disease, 19(1), pp.78~83 (2009), 대한 소아알레르기 호흡기학회
  19. 김무정, "수원의 한 대학병원에서 10년간 경험한 아나필락시스 환자 분석", 천식 및 알레르기, 28(4), pp.298~304 (2008), 대한천식알레르기학회
  20. 노의정, "국내 중부지역 아나필락시스 환자의 임상적 특성 연구", Allergy Asthma & Respiratory Disease, 18(1), pp.61~69 (2008), 대한 소아알레르기 호흡기학회
  21. 박향미, "단일 의료기관에서 진단된 아나필락시스 환자의 임상적 특성", Allergy Asthma & Respiratory Disease, 22(3), pp.232~238 (2012), 대한 소아알레르기 호흡기학회
  22. 장광천, "한국 아나필락시스의 진료", Allergy Asthma & Respiratory Disease, 1(3), pp.181~196 (2013), 대한 소아알레르기 호흡기학회
  23. 임대현, "소아청소년에서 아나필락시스의 역학", Clinical and Experimental Pediatrics, 51(4), pp.351~354 (2008), 대한소아청소년과학회
  24. Yang MS, "True rise in anaphylaxis incidence: epidemiologic study based on a national health insurance database", Medicine (Baltimore), 96, pp.e5750~ (2017)[DOI]
  25. Jeong K, "A population-based epidemiological study of anaphylaxis using national big data in Korea: trends in age-specific prevalence and epinephrine use in 2010-2014", Allergy Asthma Clin Immunol, 14, pp.31~ (2018)[DOI]
  26. 이수영, "응급실 내원 소아청소년에서 심한 식품알레르기의 발생 빈도와 임상 특징", 천식 및 알레르기, 32(3), pp.169~175 (2012), 대한천식알레르기학회
  27. 이소연, "A Multicenter Retrospective Case Study of Anaphylaxis Triggers by Age in Korean Children", Allergy, Asthma & Immunology Research, 8(6), pp.535~540 (2016), 대한천식알레르기학회
  28. Jeong K, "A multicenter study on anaphylaxis caused by peanut, tree nuts, and seeds in children and adolescents", Allergy, 72, pp.507~510 (2017)[DOI]
  29. Muraro A, "Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology", Allergy, 69, pp.1026~1045 (2014)[DOI]
  30. Simons FE, "World Allergy Organization Anaphylaxis Guidelines: 2013 update of the evidence base", Int Arch Allergy Immunol, 162, pp.193~204 (2013)[DOI]
  31. Grabenhenrich L, "Implementation of anaphylaxis management guidelines: a register-based study", PLoS One, 7, pp.e35778~ (2012)[DOI]
  32. Lin RY, "Increasing anaphylaxis hospitalizations in the first 2 decades of life: New York State, 1990-2006", Ann Allergy Asthma Immunol, 101, pp.387~393 (2008)[DOI]
  33. Nocerino R, "Increasing rate of hospitalizations for food-induced anaphylaxis in Italian children: an analysis of the Italian Ministry of Health database", J Allergy Clin Immunol, 135, pp.833~835 (2015)[DOI]
  34. Liew WK, "Anaphylaxis fatalities and admissions in Australia", J Allergy Clin Immunol, 123, pp.434~442 (2009)[DOI]
  35. Lee S, "Study on prevention of food allergy" (2015)
  36. 이정민, "4세 미만 소아에서 호두 알레르기의 임상 특성과 땅콩과의 교차 반응성 연구", Allergy Asthma & Respiratory Disease, 21(4), pp.261~268 (2011), 대한 소아알레르기 호흡기학회
  37. 이정민, "소아 키위 알레르기의 임상 특성과 특이 immunoglobulin E 항체의 유용성", Allergy Asthma & Respiratory Disease, 1(1), pp.73~78 (2013), 대한 소아알레르기 호흡기학회
  38. 임자현, "즉시형 우유 알레르기 환자에서 카제인 특이 IgE와 IgG의 유용성", Allergy Asthma & Respiratory Disease, 3(2), pp.139~144 (2015), 대한 소아알레르기 호흡기학회
  39. 양송이, "한국 소아의 식품 의존성 운동유발 아나필락시스: 단일 기관 후향적 연구", Allergy Asthma & Respiratory Disease, 3(3), pp.194~199 (2015), 대한 소아알레르기 호흡기학회
  40. 김민지, "Prevalence of Immediate-Type Food Allergy in Korean Schoolchildren in 2015: A Nationwide, Population-based Study", Allergy, Asthma & Immunology Research, 9(5), pp.410~416 (2017), 대한천식알레르기학회
  41. 박미란, "Prevalence of Immediate-Type Food Allergy in Early Childhood in Seoul", Allergy, Asthma & Immunology Research, 6(2), pp.131~136 (2014), 대한천식알레르기학회
  42. 정경욱, "Age- Based Causes and Clinical Characteristics of Immediate-Type Food Allergy in Korean Children", Allergy, Asthma & Immunology Research, 9(5), pp.423~430 (2017), 대한천식알레르기학회
  43. 정소윤, "알부민에 의한 아나필락시스를 보인 소아에서 성공적인탈감작 적용 1예", Allergy Asthma & Respiratory Disease, 5(2), pp.117~120 (2017), 대한 소아알레르기 호흡기학회[DOI]
  44. 강준석, "휴대용 에피네프린 처방률을 포함한 소아 아나필락시스의연구", Allergy Asthma & Respiratory Disease, 5(3), pp.135~140 (2017), 대한 소아알레르기 호흡기학회[DOI]
  45. 서대홍, "국내 단일 병원 의료관계자들의 아나필락시스 인지도 조사", Allergy Asthma & Respiratory Disease, 4(2), pp.133~139 (2016), 대한 소아알레르기 호흡기학회[DOI]
  46. Wood RA, "Anaphylaxis in America: the prevalence and characteristics of anaphylaxis in the United States", J Allergy Clin Immunol, 133, pp.461~467 (2014)[DOI]
  47. Nwaru BI, "Prevalence of common food allergies in Europe: a systematic review and meta-analysis", Allergy, 69, pp.992~1007 (2014)[DOI]
  48. Patel A, "Hypersensitivities to sesame and other common edible seeds", Allergy, 71, pp.1405~1413 (2016)[DOI]
  49. Imai T, "A report on 2011 nationwide survey of immediate type food allergies in Japan (supported by a grant from "consumer affairs agency, government of Japan")", Arerugi, 65, pp.942~946 (2016)
  50. Nannan Jiang, "Characteristics of Anaphylaxis in 907 Chinese Patients Referred to a Tertiary Allergy Center: A Retrospective Study of 1,952 Episodes", Allergy, Asthma & Immunology Research, 8(4), pp.353~361 (2016), 대한천식알레르기학회
  51. Tanno LK, "Field-testing the new anaphylaxis'classification for the WHO International Classification of Diseases-11 revision", Allergy, 72, pp.820~826 (2017)[DOI]
  52. 조연주, "소아 아나필락시스 상병등록의 적절성", Allergy Asthma & Respiratory Disease, 5(3), pp.159~164 (2017), 대한 소아알레르기 호흡기학회[DOI]
  53. Worm M, "First European data from the network of severe allergic reactions (NORA)", Allergy, 69, pp.1397~1404 (2014)[DOI]
  54. Barzegar S, "Common causes of anaphylaxis in children: the first report of anaphylaxis registry in iran", World Allergy Organ J, 3, pp.9~13 (2010)[DOI]
  55. Grabenhenrich LB, "Anaphylaxis in children and adolescents: The European Anaphylaxis Registry", J Allergy Clin Immunol, 137, pp.1128~1137 (2016)[DOI]
  56. Li X, "Tanshinone IIA suppresses TEX>$Fc{\varepsilon}RI$<", TEX>-mediated mast cell signaling and anaphylaxis by activation of the Sirt1, AMPK pathway, pp.Biochem Pharmacol, 2018[DOI]
  57. Heaps A, "The utility of the ISAC allergen array in the investigation of idiopathic anaphylaxis", Clin Exp Immunol, 177, pp.483~490 (2014)[DOI]
  58. Eldredge C, "Assessing the readiness of a school system to adopt food allergy management guidelines", WMJ, 113, pp.155~161 (2014)
  59. Jarvinen KM, "Anaphylaxis avoidance and management: educating patients and their caregivers", J Asthma Allergy, 7, pp.95~104 (2014)
  60. O'Keefe A, "The risk of recurrent anaphylaxis", J Pediatr, 180, pp.217~221 (2017)[DOI]
  61. Cianferoni A, "Anaphylaxis: a 7-year follow-up survey of 46 children", Ann Allergy Asthma Immunol, 92, pp.464~468 (2004)[DOI]
  62. Bousquet J, "Systems medicine and integrated care to combat chronic noncommunicable diseases", Genome Med, 3, pp.43~ (2011)[DOI]
  63. 이은주, "소아의 즉시형 우유와 난백 알레르기의 임상 특성과 식품 노출 형태", Allergy Asthma & Respiratory Disease, 5(6), pp.351~357 (2017), 대한 소아알레르기 호흡기학회[DOI]

관련 논문AI추천

한국 소아 식품알레르기의 연구 현황과 과제안강모한국 아나필락시스의 진료강혜련, 김지현, 김혜원, 문희범, 박해심, 송우정, 신미용, 안영민, 예영민, 이수영, 이수진, 장광천, 장윤석, 정재우, 진현정, 최선희대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2013 · 제1권 제3호국내 소아 식품알레르기의 역학대한 소아알레르기 호흡기학회 식품알레르기 아토피피부염 연구회, 김경원, 김우경, 김윤희, 김정희, 김지현, 김현희, 김혜영, 민택기, 박용민, 송태원, 안강모, 염혜영, 이소연, 이수영, 이용주, 이정민, 장광천, 전유훈, 편복양대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2018 · 제6권 제1호국내 중부지역 아나필락시스 환자의 임상적 특성 연구김한진, 노의정, 박준수, 우성일, 윤유숙, 이미희, 이수진, 이재호, 정은희, 한윤수대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2008 · 제18권 제1호휴대용 에피네프린 처방률을 포함한 소아 아나필락시스의연구강준석, 김태호, 김혜선, 박준수, 방현호, 이현정, 황보영대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2017 · 제5권 제3호강원도 내 소아청소년 교육기관 아나필락시스 실태 및 관리: 보건교사 및 보육교사 설문조사권재우, 김자경, 박진성대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2022 · 제10권 제1호
원문 보기