Polyethylene glycol에 의한 아나필락시스 1예
Anaphylaxis due to polyethylene glycol: A case report
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Polyethylene glycol (PEG) is a major component of bowel preparation solution for colonoscopy. It has been recognized as a safe and effective osmotic laxative that is rarely immunogenic. We here report a case of anaphylaxis due to PEG. A 49-year-old female came to the outpatient clinic wanting to find the cause of skin rash, nausea and respiratory difficulty after ingesting bowel evacuant solution (Clicool). She had visited local Emergency Department at the time of event and was diagnosed with anaphylaxis. We performed skin tests with components of Clicool to identify the cause of anaphylactic reactions. The result showed a positive skin response only to PEG. In contrast, skin test done in the control showed no reactions to PEG. This is the first case that revealed PEG to be an exact cause of anaphylaxis after ingesting a bowel evacuant.
Abstract
Polyethylene glycol (PEG) is a major component of bowel preparation solution for colonoscopy. It has been recognized as a safe and effective osmotic laxative that is rarely immunogenic. We here report a case of anaphylaxis due to PEG. A 49-year-old female came to the outpatient clinic wanting to find the cause of skin rash, nausea and respiratory difficulty after ingesting bowel evacuant solution (Clicool). She had visited local Emergency Department at the time of event and was diagnosed with anaphylaxis. We performed skin tests with components of Clicool to identify the cause of anaphylactic reactions. The result showed a positive skin response only to PEG. In contrast, skin test done in the control showed no reactions to PEG. This is the first case that revealed PEG to be an exact cause of anaphylaxis after ingesting a bowel evacuant.
참고문헌 (6)
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- Sun Hee Lee, "Anaphylactic Shock Caused by Ingestion of Polyethylene Glycol", Intestinal research, 13(1), pp.90~94 (2015), 대한장연구학회[DOI]
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- 이진선, "경구 Polyethylene Glycol (PEG) 복용 후에 생긴 두드러기", Clinical Endoscopy, 24(5), pp.299~301 (2002), 대한소화기내시경학회
- 이소희, "Anaphylaxis to Polyethylene Glycol (Colyte®) in a Patient with Diverticulitis", Journal of Korean Medical Science, 31(10), pp.1662~1663 (2016), 대한의학회
- Wenande E, "Immediate-type hypersensitivity to polyethylene glycols: a review", Clin Exp Allergy, 46, pp.907~922 (2016)[DOI]