소아 크룹 입원 환자의 병인과 계절적 변동: 6년간의 다기관 후향적 연구(2010–2015년)
Seasonal patterns and etiologies of croup in children during the period 2010–2015: A multicenter retrospective study
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Purpose: Croup is known to have epidemics in seasonal and biennial trends, and to be strongly associated with epidemics of parainfluenza virus. However, seasonal and annual epidemics of croup have not been clearly reported in Korea. This study aimed to examine the seasonal/annual patterns and etiologies of childhood croup in Korea during a consecutive 6-year period. Methods: Pediatric croup data were collected from 23 centers in Korea from 1 January 2010 to 31 December 2015. Electronic medical records, including multiplex reverse transcription polymerase chain reaction (RT-PCR) results, demographics and clinical information were cross-sectionally reviewed and analyzed. Results: Overall, 2,598 childhood croup patients requiring hospitalization were identified during the study period. Among them, a total of 927 who underwent RT-PCR were included in the analysis. Males (61.5%) predominated, and most (63.0%) of them were younger than 2 years of age (median, 19 months; interquartile range, 11–31 months). Peak hospitalization occurred in 2010 and 2012 in even-numbered years, and parainfluenza virus (PIV, 39.7%) was the most common cause of childhood croup requiring hospitalization, followed by respiratory syncytial virus (14.9%), human rhinovirus (12.5%), Mycoplasma pneumonaie (10.6%), and human coronavirus (7.3%). Conclusion: It is concluded that croup hospitalization has a biennial pattern in even-numbered years. PIV may be the most common cause of childhood croup; however, croup epidemics could be attributed to other viruses.
Abstract
Purpose: Croup is known to have epidemics in seasonal and biennial trends, and to be strongly associated with epidemics of parainfluenza virus. However, seasonal and annual epidemics of croup have not been clearly reported in Korea. This study aimed to examine the seasonal/annual patterns and etiologies of childhood croup in Korea during a consecutive 6-year period. Methods: Pediatric croup data were collected from 23 centers in Korea from 1 January 2010 to 31 December 2015. Electronic medical records, including multiplex reverse transcription polymerase chain reaction (RT-PCR) results, demographics and clinical information were cross-sectionally reviewed and analyzed. Results: Overall, 2,598 childhood croup patients requiring hospitalization were identified during the study period. Among them, a total of 927 who underwent RT-PCR were included in the analysis. Males (61.5%) predominated, and most (63.0%) of them were younger than 2 years of age (median, 19 months; interquartile range, 11–31 months). Peak hospitalization occurred in 2010 and 2012 in even-numbered years, and parainfluenza virus (PIV, 39.7%) was the most common cause of childhood croup requiring hospitalization, followed by respiratory syncytial virus (14.9%), human rhinovirus (12.5%), Mycoplasma pneumonaie (10.6%), and human coronavirus (7.3%). Conclusion: It is concluded that croup hospitalization has a biennial pattern in even-numbered years. PIV may be the most common cause of childhood croup; however, croup epidemics could be attributed to other viruses.
참고문헌 (33)
- Cherry JD, "Clinical practice", Croup. N Engl J Med, 358, pp.384~391 (2008)
- Bjornson CL, "Croup", Lancet, 371, pp.329~339 (2008)
- 이두리, "Clinical characteristics of children and adolescents with croup and epiglottitis who visited 146 Emergency Departments in Korea", Clinical and Experimental Pediatrics, 58(10), pp.380~385 (2015), 대한소아청소년과학회
- McEniery J, "Review of intubation in severe laryngotracheobronchitis", Pediatrics, 87, pp.847~853 (1991)
- Denny FW, "Croup: an 11-year study in a pediatric practice", Pediatrics, 71, pp.871~876 (1983)
- Segal AO, "Croup hospitalizations in Ontario: a 14-year time-series analysis", Pediatrics, 116, pp.51~55 (2005)
- Marx A, "Pediatric hospitalizations for croup (laryngotracheobronchitis): biennial increases associated with human parainfluenza virus 1 epidemics", J Infect Dis, 176, pp.1423~1427 (1997)
- Rosychuk RJ, "Seasonality patterns in croup presentations to emergency departments in Alberta, Canada: a time series analysis", Pediatr Emerg Care, 27, pp.256~260 (2011)
- Weinberg GA, "Parainfluenza virus infection of young children: estimates of the population-based burden of hospitalization", J Pediatr, 154, pp.694~699 (2009)
- Rihkanen H, "Respiratory viruses in laryngeal croup of young children", J Pediatr, 152, pp.661~665 (2008)
- Wall SR, "The viral aetiology of croup and recurrent croup", Arch Dis Child, 94, pp.359~360 (2009)
- 김은진, "후두기관지폐렴으로 진단된 소아 환자들의 임상 양상과 원인: 크룹 환아와의 비교", Allergy Asthma & Respiratory Disease, 5(5), pp.274~279 (2017), 대한 소아알레르기 호흡기학회[DOI]
- 전인수, "바이러스성 크루프로 입원하는 소아 환자의 역학적특성과 임상적 중증도 평가", Pediatric Infection and Vaccine, 25(1), pp.8~16 (2018), 대한소아감염학회[DOI]
- 김금향, "하기도 감염으로 입원한 소아에서 12종 바이러스의 검출 및 임상 양상", Clinical and Experimental Pediatrics, 51(8), pp.834~841 (2008), 대한소아청소년과학회
- Sung JY, "Role of human coronavirus NL63 in hospitalized children with croup", Pediatr Infect Dis J, 29, pp.822~826 (2010)
- van der Hoek L, "Croup is associated with the novel coronavirus NL63", PLoS Med, 2, pp.e240~ (2005)
- van der Hoek L, "Identification of a new human coronavirus", Nat Med, 10, pp.368~373 (2004)
- Chiu SS, "Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong, China", Clin Infect Dis, 40, pp.1721~1729 (2005)
- Han TH, "Human Coronavirus-NL63 infections in Korean children, 2004-2006", J Clin Virol, 38, pp.27~31 (2007)
- Wu PS, "Clinical manifestations of human coronavirus NL63 infection in children in Taiwan", Eur J Pediatr, 167, pp.75~80 (2008)
- Zeng ZQ, "Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China", Eur J Clin Microbiol Infect Dis, 37, pp.363~369 (2018)
- Regamey N, "Viral etiology of acute respiratory infections with cough in infancy: a community-based birth cohort study", Pediatr Infect Dis J, 27, pp.100~105 (2008)
- Camara AA, "Risk factors for wheezing in a subtropical environment: role of respiratory viruses and allergen sensitization", J Allergy Clin Immunol, 113, pp.551~557 (2004)
- Manning A, "Epidemiological profile and clinical associations of human bocavirus and other human parvoviruses", J Infect Dis, 194, pp.1283~1290 (2006)
- Gagliardi TB, "Human bocavirus respiratory infections in children", Epidemiol Infect, 137, pp.1032~1036 (2009)
- Jartti T, "Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children", J Med Virol, 72, pp.695~699 (2004)
- von Linstow ML, "Clinical and epidemiologic characteristics of human bocavirus in Danish infants: results from a prospective birth cohort study", Pediatr Infect Dis J, 27, pp.897~902 (2008)
- Williams JV, "Population-based incidence of human metapneumovirus infection among hospitalized children", J Infect Dis, 201, pp.1890~1898 (2010)
- Everard ML, "Acute bronchiolitis and croup", Pediatr Clin North Am, 56, pp.119~133 (2009)
- Chapman RS, "The epidemiology of tracheobronchitis in pediatric practice", Am J Epidemiol, 114, pp.786~797 (1981)
- Waites KB, "The role of Mycoplasma in upper respiratory infections", Curr Infect Dis Rep, 11, pp.198~206 (2009)
- Tyler A, "Variation in Inpatient Croup Management and Outcomes", Pediatrics, 139(4), pp.e20163582~ (2017)
- Syrmis MW, "A sensitive, specific, and cost-effective multiplex reverse transcriptase-PCR assay for the detection of seven common respiratory viruses in respiratory samples", J Mol Diagn, 6, pp.125~131 (2004)