조절 T 세포에 대한 최신 지견
Current Concepts in Regulatory T cell
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During the last few years, the concept of regulatory T (Treg) cells has received general attention by the scientific community. The activity of Tregs may be critical in the immune outcome to allergen and hence the development of allergic versus nonallergic responses. Two main groups of Treg cell, such as natural Treg cells and inducible Treg cells (Tr1 cells and Th3 cells) have been defined. The search of better Treg cell markers have been continued, and Foxp3, CD25, CD127, folate receptor 4, HLA-DR and CCR 6 could be used. Recent research reveals the cellular and molecular basis of Treg development and function. In allergic diseases, such as asthma, atopic dermatitis and food allergy, many evidences those Treg cells contribute to the control of disease have been showed. This review focuses on current concepts in Treg cell including development, characteristics, cell markers, and cellular and molecular research of Treg cells and Treg cells in allergic diseases. This may be important for advancing our understanding of allergic disease and possible therapeutic applications for the treatment of disease those are associated with a dysfunction in T cell regulation.
Abstract
During the last few years, the concept of regulatory T (Treg) cells has received general attention by the scientific community. The activity of Tregs may be critical in the immune outcome to allergen and hence the development of allergic versus nonallergic responses. Two main groups of Treg cell, such as natural Treg cells and inducible Treg cells (Tr1 cells and Th3 cells) have been defined. The search of better Treg cell markers have been continued, and Foxp3, CD25, CD127, folate receptor 4, HLA-DR and CCR 6 could be used. Recent research reveals the cellular and molecular basis of Treg development and function. In allergic diseases, such as asthma, atopic dermatitis and food allergy, many evidences those Treg cells contribute to the control of disease have been showed. This review focuses on current concepts in Treg cell including development, characteristics, cell markers, and cellular and molecular research of Treg cells and Treg cells in allergic diseases. This may be important for advancing our understanding of allergic disease and possible therapeutic applications for the treatment of disease those are associated with a dysfunction in T cell regulation.
참고문헌 (37)
- Romagnani S, "Immunologic influences on allergy and the TH1", TH2 balance, 2004, pp.113, 395~400
- McGeady SJ, "Depression of cell-mediated immunity in atopic eczema", J Allergy Clin Immunol, 56, pp.393~406
- Sakaguchi S, "Regulatory T cells and immune tolerance", Cell, 133, pp.775~787 (2008)
- Ochs HD, "Foxp3 acts as a rheostat of the immune response", Immunol Rev, 20, pp.156~164 (2005)
- Woodfolk JA, "T-cell responses to allergens", J Allergy Clin Immunol, 119, pp.280~294 (2007)
- Taylor A, "T regulatory cells and allergy", Microbes and Infection, 7, pp.1049~1055 (2005)
- Shevach EM, "The life style of naturally occurring CD4＋CD25＋Foxp3＋ regulatory T cells", Immunol Rev, 212, pp.60~73 (2006)
- Haribhai D, "Regulatory T cells dynamically control the primary immune response to foreign antigen", J Immunol, 178, pp.2961~2972 (2007)
- Reefer AJ, "Analysis of CD25hiCD4＋ "regulatory" T-cell subtypes in atopic dermatitis reveals a novel Th2-like population", J Allergy Clin Immunol, 121, pp.415~422 (2008)
- Koonpaew S, "LAT-mediated signaling in CD4＋CD25＋ regulatory T cell development", J Exp Med, 203, pp.119~129 (2006)
- Sakaguchi S, "Naturally arising Foxp3-expressing CD25＋CD4＋ regulatory T cells in immunological tolerance to self and non-self", Nat Immunol, 6, pp.345~352 (2005)
- Watanabe N, "Hassalls corpuscles instruct dendritic cells to induce CD4＋CD25＋ regulatory T cells in human thymus", Nature, 436, pp.1181~1185 (2005)
- Bettelli E, "Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cell", Nature, 441, pp.235~238 (2006)
- Laurence A, "Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation", Immunity, 26, pp.371~381 (2007)
- Sun CM, "Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 Treg cells via retinoic acid", J Exp Med, 204, pp.1775~1785 (2007)
- Smith M, "Children with egg allergy have evidence of reduced neonatal CD4＋CD25＋CD127lo", - regulatory T cell function, 2008, pp.212, 1460~1466
- Song TW, "Analysis of circulating CD25hi CD4＋T cells in atopic dermatitis reveals age-related changes in early life", J Allergy Clin Immunol, 121, pp.283~284 (2008)
- Akdis M, "T regulatory cells in allergy:Novel concepts in the pathogenesis, prevention, and treatment of allergic diseases", J Allergy Clin Immunol, 116, pp.961~968 (2005)
- Vignali DAA, "How regulatory T cells work", Nature Rev Immunol, 8, pp.523~532 (2008)
- Fontenot JD, "Regulatory T cell lineage specification by the forkhead transcription factor Foxp3", Immunity, 22, pp.329~341 (2005)
- Morgan ME, "Expression of Foxp3 mRNA is not confined to CD4＋CD25＋ T regulatory cells in humans", Hum Immunol, 66, pp.13~20 (2005)
- Wang J, "Transient expression of Foxp3 in human activated nonregulatory CD4＋ T cells", Eur J Immunol, 37, pp.129~138 (2007)
- Liu W, "CD127 expression inversely correlates with Foxp3 and suppressive function of human CD4＋ Treg cells", J Exp Med, 203, pp.1701~1711 (2006)
- Kleinwietfeld M, "CCR6 expression defines regulatory effector", memory-like cells within the CD25＋CD4＋ T- cell subset, 2005, pp.105, 2877~2886
- Baecher-Allan C, "MHC class II expression identifies functionally distinct human regulatory T cells", J Immunol, 176, pp.4622~4631 (2006)
- Yamaguchi T, "Control of immune responses by antigen- specific regulatory T cells expressing the folate receptor", Immunity, 27, pp.145~159 (2007)
- Hirahara K, "The majority of human peripheral blood CD4＋CD25highFoxp3＋ regulatory T cells bear functional skin-homing receptors", J Immunol, 177, pp.4488~4894 (2006)
- Hoshino M, "Expression of growth factors and remodelling of the airway wall in bronchial asthma", Thorax, 53, pp.21~27 (1998)
- Peek EJ, "Interleukin-10- secreting "regulatory" T cells induced by glucocorticoids and beta2-agonists", Am J Respir Cell Mol Biol, 33, pp.105~111 (2005)
- Karagiannidis C, "Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma", J Allergy Clin Immunol, 114, pp.1425~1433 (2004)
- Joetham A, "Naturally occurring lung CD4＋CD25＋ T cell regulation of airway allergic responses depends on IL-10 induction of TGF-β", J Immunol, 178, pp.1433~1442 (2007)
- Ling EM, "Relation of CD4＋CD25＋ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease", Lancet, 363, pp.608~615 (2004)
- Cardona ID, "Staphylococcal enterotoxin B inhibits regulatory T cells by inducing glugocorticoid -inducing TNF receptor-related protein ligand on monocytes", J Allergy Clin Immunol, 117, pp.688~695 (2006)
- Caproni M, "The effects of tacrolimus ointment on regulatory T lymphocytes in atopic dermatitis", J Clin Immunol, 26, pp.370~375 (2006)
- Akdis M, "Immune responses in healthy and allergic individuals characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells", J Exp Med, 199, pp.1567~1575 (2004)
- Francis JN, "Induction of IL-10＋CD4＋CD25＋ T cells by grass pollen immunotherapy", J Allergy Clin Immunol, 111, pp.1255~1261 (2003)
- Akdis CA, "Role of interleukin-10 in specific immunotherapy", J Clin Invest, 102, pp.98~106 (1998)