만성 폐쇄성 폐질환에서 우울증이 호흡기 증상과 삶의 질에 미치는 영향
Effect of Depression on Pulmonary Symptoms and Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objectives Depression is a common comorbid condition in patients with chronic obstructive pulmonary disease (COPD) and has a higher prevalence than the general population. On the other hand, studies on the incidence of depression and quality of life in COPD patients often depend on a simple self-report questionnaire rather than a psychiatrist’s clinical assessment. Starting with accurately diagnosing depression, the purpose of this study was to evaluate the factors related to depression as well as how depression influences the quality of life. Methods The study included 30 patients diagnosed with COPD. All the patients were interviewed for a diagnosis of depression by a psychiatrist. They were divided into two groups: with and without depression. For dyspnea, the modified Medical Research Council (mMRC) scale was used to evaluate how it affected daily life. Short-Form Health Survey 36 and COPD assessment test (CAT) were used to assess the quality of life. Results The degree of COPD and respiratory symptoms were related, but the severity of COPD did not influence the quality of life. In the presence of depression, mMRC and CAT were higher, whereas PCS and MCS were lower than in those without depression. Patients with depression suffered more from dyspnea and had a lower quality of life. Conclusion This study suggests that the degree of COPD was not related to depression. With depression, however, it led to the aggravation of dyspnea and a deteriorated quality of life. Combined treatment is essential to improving the patients’ general well-being.
Abstract
Objectives Depression is a common comorbid condition in patients with chronic obstructive pulmonary disease (COPD) and has a higher prevalence than the general population. On the other hand, studies on the incidence of depression and quality of life in COPD patients often depend on a simple self-report questionnaire rather than a psychiatrist’s clinical assessment. Starting with accurately diagnosing depression, the purpose of this study was to evaluate the factors related to depression as well as how depression influences the quality of life. Methods The study included 30 patients diagnosed with COPD. All the patients were interviewed for a diagnosis of depression by a psychiatrist. They were divided into two groups: with and without depression. For dyspnea, the modified Medical Research Council (mMRC) scale was used to evaluate how it affected daily life. Short-Form Health Survey 36 and COPD assessment test (CAT) were used to assess the quality of life. Results The degree of COPD and respiratory symptoms were related, but the severity of COPD did not influence the quality of life. In the presence of depression, mMRC and CAT were higher, whereas PCS and MCS were lower than in those without depression. Patients with depression suffered more from dyspnea and had a lower quality of life. Conclusion This study suggests that the degree of COPD was not related to depression. With depression, however, it led to the aggravation of dyspnea and a deteriorated quality of life. Combined treatment is essential to improving the patients’ general well-being.
참고문헌 (41)
- "Goldcopd.org"[URL]
- Lopez AD, "Chronic obstructive pulmonary disease : current burden and future projections", Eur Respir J, 27, pp.397~412 (2006)
- Mathers CD, "Projections of global mortality and burden of disease from 2002 to 2030", PLoS Med, 3, pp.2011~2030 (2006)
- Murray CJ, "Alternative projections of mortality and disability by cause 1990-2020 : Global Burden of Disease Study", Lancet, 349, pp.1498~1504 (1997)
- Buist AS, "International variation in the prevalence of COPD(the BOLD Study) : a population-based prevalence study", Lancet, 370, pp.741~750 (2007)
- Chun CM, "Prevalence of chronic obstructive pulmonary disease among adults over 40 years old in Korea, 2009-2013", Public Health Weekly Report, PHWR, 8, pp.334~337 (2015)
- "kostat.go.kr"[URL]
- Hillas G, "Managing comorbidities in COPD", Int J Chron Obstruct Pulmon Dis, 10, pp.95~109 (2015)
- Hynninen KM, "Psychological characteristics of patients with chronic obstructive pulmonary disease : a review", J Psychosom Res, 59, pp.429~443 (2005)
- Atlantis E, "Bidirectional associations between clinically relevant depression or anxiety and COPD : a systematic review and meta-analysis", Chest, 144, pp.766~777 (2013)
- Solano JP, "A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease", J Pain Symptom Manage, 31, pp.58~69 (2006)
- Pumar MI, "Anxiety and depression-Important psychological comorbidities of COPD", J Thorac Dis, 6, pp.1615~1631 (2014)
- DiMatteo MR, "Depression is a risk factor for noncompliance with medical treatment : meta-analysis of the effects of anxiety and depression on patient adherence", Arch Intern Med, 160, pp.2101~2107 (2000)
- Ormel J, "Functioning, well-being, and health perception in late middleaged and older people: comparing the effects of depressive", J Am Geriatr Soc, 46, pp.39~48 (1998)
- Jang SM, "Depression is a major determinant of both disease-specific and generic health-related quality of life in people with severe COPD", Chron Respir Dis, 16, pp.1~8 (2019)
- 류연주, "만성폐쇄성폐질환 환자에서 우울과 불안심리 평가", Tuberculosis and Respiratory Diseases, 62(1), pp.11~18 (2007), 대한결핵및호흡기학회
- 진현정, "폐쇄성폐질환에서 우울증상의 빈도 및 위험 인자", Tuberculosis and Respiratory Diseases, 65(3), pp.191~197 (2008), 대한결핵및호흡기학회
- Yohannes AM, "Depression and anxiety in chronic heart failure and chronic obstructive pulmonary disease : prevalence, relevance, clinical implications and management principles", Int J Geriatr Psychiatry, 25, pp.1209~1221 (2010)
- Matte DL, "Prevalence of depression in COPD : a systematic review and meta-analysis of controlled studies", Respir Med, 117, pp.154~161 (2016)
- Bestall JC, "Usefulness of the Medical Research Council(MRC)dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease", Thorax, 54, pp.581~586 (1999)
- American Psychiatry Association, "Diagnostic and statistical manual of mental disorders-DSM-IV" (1995), Hana Medical Science Publish
- 이중서, "한국판 Hamilton 우울증 평가 척도의 신뢰도, 타당도 연구", 신경정신의학, 44(4), pp.456~465 (2005), 대한신경정신의학회
- Koh SB, "Reliability and validity on measurement instrument for health status assessment in occupational workers", Korean Journal of Preventive Medicine, 30, pp.251~266 (1997)
- Ware JE, "User’s manual for the SF-36v2 health", Quality Metric Incorporated, ~ (2007)
- Jones PW, "Development and first validation of the COPD Assessment Test", Eur Respir J, 34, pp.648~654 (2009)
- 황용일, "A Validation Study for the Korean Version of Chronic Obstructive Pulmonary Disease Assessment Test (CAT)", Tuberculosis and Respiratory Diseases, 74(6), pp.256~263 (2013), 대한결핵및호흡기학회
- Hansen MS, "Mental disorders among internal medical inpatients : prevalence, detection, and treatment status", J Psychosom Res, 50, pp.199~204 (2001)
- Kunik ME, "Surprisingly high prevalence of anxiety and depression in chronic breathing disorders", Chest, 127, pp.1205~1211 (2005)
- Yohannes AM, "Long-term course of depression trajectories in patients with COPD : a 3-year follow-up analysis of the evaluation of COPD longitudinally to identify predictive surrogate endpoints cohort", Chest, 149, pp.916~926 (2016)
- Cao Z, "Frequent hospital readmissions for acute exacerbation of COPD and their associated factors", Respirology, 11, pp.188~195 (2006)
- Yohannes AM, "Predictors of 1-year mortality in patients discharged from hospital following acute exacerbation of chronic obstructive pulmonary disease", Age Ageing, 34, pp.491~496 (2005)
- Vestbo J, "Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease : GOLD executive summary", Am J Respir Crit Care Med, 187, pp.347~365 (2013)
- Hanania NA, "Determinants of depression in the ECLIPSE chronic obstructive pulmonary disease cohort", Am J Respir Crit Care Med, 183, pp.604~611 (2011)
- Di Marco F, "Anxiety and depression in COPD patients : the roles of gender and disease severity", Respir Med, 100, pp.1767~1774 (2006)
- Isoaho R, "Chronic obstructive pulmonary disease and symptoms related to depression in elderly persons", Psychol Rep, 76, pp.287~297 (1995)
- Regvat J, "Anxiety and depression during hospital treatment of exacerbation of chronic obstructive pulmonary disease", J Int Med Res, 39, pp.1028~1038 (2011)
- Lasser K, "Smoking and mental illness : a population-based prevalence study", JAMA, 284, pp.2606~2610 (2000)
- Glassman AH, "Smoking, smoking cessation, and major depression", JAMA, 264, pp.1546~1549 (1990)
- Wiesbeck GA, "Tobacco smoking and depression--results from the WHO", ISBRA study, 2008, pp.57, 26~31
- 류연주, "Prevalence of Depression and Anxiety in Outpatients with Chronic Airway Lung Disease", The Korean Journal of Internal Medicine, 25(1), pp.51~57 (2010), 대한내과학회
- Doyle T, "Association of anxiety and depression with pulmonary-specific symptoms in chronic obstructive pulmonary disease", Int J Psychiatry Med, 45, pp.189~202 (2013)