계란 알레르기 환아에서 인플루엔자 백신 접종의 안정성에 대한 연구
The safety of influenza vaccination in children with egg allergy
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Purpose: Although influenza vaccine contains some residual egg protein (ovalbumin), recent studies have been reported that the influenza vaccine is even safe for patients with egg allergy. The object of this study was to assess the safety of influenza vaccination and estimate the risk factors of allergic reactions to influenza vaccination in children with egg allergy. Methods: The medical records of 108 children were reviewed retrospectively, those were diagnosed as egg allergy at Department of Pediatrics in Severance Children’s Hospital between January 2006 and December 2011. All of them were vaccinated with very low ovalbumin concentration (≤0.12 μg/mL). Patients were vaccinated in graded doses by the international guideline. Subjects without allergic reactions to influenza vaccine among egg allergy patients were recruited as control subjects. Results: Only 12 subjects of patients had adverse reactions to influenza vaccination. There were no significant relationships between adverse reactions to influenza vaccine and their own history of other allergy, history of breast feeding or graded vaccination. The egg allergy symptoms or egg-specific IgE levels were not associated with adverse reactions to influenza vaccination. Conclusion: These results show that patients with egg allergy may have adverse reactions with influenza vaccine, but severe adverse reactions are rare as general population. Therefore, the patients with egg allergy can be safe vaccinated with influenza vaccine, regardless of severity of allergic reaction after egg ingestion or methods of vaccination.
Abstract
Purpose: Although influenza vaccine contains some residual egg protein (ovalbumin), recent studies have been reported that the influenza vaccine is even safe for patients with egg allergy. The object of this study was to assess the safety of influenza vaccination and estimate the risk factors of allergic reactions to influenza vaccination in children with egg allergy. Methods: The medical records of 108 children were reviewed retrospectively, those were diagnosed as egg allergy at Department of Pediatrics in Severance Children’s Hospital between January 2006 and December 2011. All of them were vaccinated with very low ovalbumin concentration (≤0.12 μg/mL). Patients were vaccinated in graded doses by the international guideline. Subjects without allergic reactions to influenza vaccine among egg allergy patients were recruited as control subjects. Results: Only 12 subjects of patients had adverse reactions to influenza vaccination. There were no significant relationships between adverse reactions to influenza vaccine and their own history of other allergy, history of breast feeding or graded vaccination. The egg allergy symptoms or egg-specific IgE levels were not associated with adverse reactions to influenza vaccination. Conclusion: These results show that patients with egg allergy may have adverse reactions with influenza vaccine, but severe adverse reactions are rare as general population. Therefore, the patients with egg allergy can be safe vaccinated with influenza vaccine, regardless of severity of allergic reaction after egg ingestion or methods of vaccination.
참고문헌 (23)
- World Health Organization Writing Group, "Non-pharmaceutical interventions for pandemic influenza, international measures", Emerg Infect Dis, 12, pp.81~87 (2006)
- Zeiger RS, "Current issues with influenza vaccination in egg allergy", J Allergy Clin Immunol, 110, pp.834~840 (2002)
- Fiore AE, "Prevention and control of influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010", MMWR Recomm Rep, 59(RR-8), pp.1~62 (2010)
- Gonzalez M, "Safety and immunogenicity of a paediatric presentation of an influenza vaccine", Arch Dis Child, 83, pp.488~491 (2000)
- Kelso JM, "Adverse reactions to vaccines practice parameter 2012 update", J Allergy Clin Immunol, 130, pp.25~43 (2012)
- 노의정, "국내 유통되는 인플루엔자 백신에서 ELISA에 의한 계란 단백의 정량적 비교", Allergy Asthma & Respiratory Diseases, 19(4), pp.345~353 (2009), 대한 소아알레르기 호흡기학회
- Savage JH, "The natural history of egg allergy", J Allergy Clin Immunol, 120, pp.1413~1417 (2007)
- Caubet JC, "Current understanding of egg allergy", Pediatr Clin North Am, 58, pp.427~443 (2011)
- 안영민, "계란 알레르기가 있는 환아들에서 알레르기 질환의 동반유무와 예후에 영향을 미치는 인자들에 대한 연구", Allergy Asthma & Respiratory Diseases, 14(1), pp.87~96 (2004), 대한 소아알레르기 호흡기학회
- Koplin JJ, "Environmental and demographic risk factors for egg allergy in a population-based study of infants", Allergy, 67, pp.1415~1422 (2012)
- Upton JE, "No systemic reactions to influenza vaccination in egg-sensitized tertiary-care pediatric patients", Allergy Asthma Clin Immunol, 8, pp.2~ (2012)
- James JM, "Safe administration of influenza vaccine to patients with egg allergy", J Pediatr, 133, pp.624~628 (1998)
- Webb L, "Singledose influenza vaccination of patients with egg allergy in a multicenter study", J Allergy Clin Immunol, 128, pp.218~219 (2011)
- Erlewyn-Lajeunesse M, "Influenza immunization in egg allergy: an update for the 2011-2012 season", Clin Exp Allergy, 41, pp.1367~1370 (2011)
- Sampson HA, "Update on food allergy", J Allergy Clin Immunol, 113, pp.805~819 (2004)
- Berger WE, "Allergic rhinitis in children: diagnosis and management strategies", Paediatr Drugs, 6, pp.233~250 (2004)
- Ly NP, "Recurrent wheeze in early childhood and asthma among children at risk for atopy", Pediatrics, 117, pp.1132~1138 (2006)
- Castro-Rodríguez JA, "A clinical index to define risk of asthma in young children with recurrent wheezing", Am J Respir Crit Care Med, 162(4 Pt 1), pp.1403~1406 (2000)
- Greenhawt MJ, "The safety of the H1N1 influenza A vaccine in egg allergic individuals", Ann Allergy Asthma Immunol, 105, pp.387~393 (2010)
- Hui CP, "Use of influenza vaccines in children with an egg allergy", Paediatr Child Health, 16, pp.491~492 (2011)
- Philppe A. Eigenmann, "Egg Allergy; Immunological and Clinical Aspects", Allergy Asthma & Respiratory Diseases, 14(2), pp.111~118 (2004), 대한 소아알레르기 호흡기학회
- Sampson HA, "Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease", Food Allergy and Anaphylaxis Network symposium, 2006, pp.117, 391~397
- Des Roches A, "Egg-allergic patients can be safely vaccinated against influenza", J Allergy Clin Immunol, 130, pp.1213~1216 (2012)