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항정신병약물 치료에 부분적인 반응을 보인 조현병 환자에 대한 아미설프라이드 병용요법의 효과와 안전성에 관한 연구

Efficacy and Safety of Augmentation Treatment With Amisulpride for Schizophrenic Patients Partially Responsive to Antipsychotics

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주제분류정신과학

초록

Objectives The response of schizophrenia or schizoaffective disorder patients to antipsychotics remains insufficient. Therefore, augmentation with additional antipsychotics is common in clinical practice. This study examined the efficacy and safety of amisulpride augmentation in schizophrenia patients partially responsive to antipsychotics. Methods Twenty-nine schizophrenia or schizoaffective disorder patients without treatment response to antipsychotics monotherapy were included in this study. Psychotic symptoms were evaluated using Brief Psychiatry Rating Scale (BPRS), Clinical Global Impression-Severity (CGI-S), and Clinical Global Impression-Improvement (CGI-I). The side effects were evaluated using Barnes Akathisia Rating Scale (BARS) and Simpson-Angus Scale (SAS) at baseline, 4 weeks, 8 weeks, and 12 weeks after the amisulpride augmentation. Results Among the 29 patients, 28 completed the study. At week 12, the mean BPRS score (p

Abstract

Objectives The response of schizophrenia or schizoaffective disorder patients to antipsychotics remains insufficient. Therefore, augmentation with additional antipsychotics is common in clinical practice. This study examined the efficacy and safety of amisulpride augmentation in schizophrenia patients partially responsive to antipsychotics. Methods Twenty-nine schizophrenia or schizoaffective disorder patients without treatment response to antipsychotics monotherapy were included in this study. Psychotic symptoms were evaluated using Brief Psychiatry Rating Scale (BPRS), Clinical Global Impression-Severity (CGI-S), and Clinical Global Impression-Improvement (CGI-I). The side effects were evaluated using Barnes Akathisia Rating Scale (BARS) and Simpson-Angus Scale (SAS) at baseline, 4 weeks, 8 weeks, and 12 weeks after the amisulpride augmentation. Results Among the 29 patients, 28 completed the study. At week 12, the mean BPRS score (p

참고문헌 (45)

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관련 논문AI추천

Clinical Usefulness of Amisulpride Add-on Therapy in Schizophrenia Patients without Treatment Response to Second-generation Antipsychotics조서은, 조성진, Chi Un Pae, Kyoung-Sae Na, Seung-Gul Kang대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2021 · 제19권 제1호Amisulpride Augmentation in Schizophrenia Patients with Poor Response to Olanzapine: A 4-week, Randomized, Rater-Blind, Controlled, Pilot Study박원명, Bo-Hyun Yoon, Sheng Min Wang, Sung-Yong Park, Won-Seok Choi, Young Sup Woo대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2022 · 제20권 제3호Amisulpride Switching in Schizophrenic Patients Who Showed Suboptimal Effect and/or Tolerability to Current Antipsychotics in a Naturalistic Setting: An Explorative Study곽경필, 김용민, 김정진, 박원명, 배치운, 왕성민, 윤호경대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2016 · 제14권 제4호Blonanserin Augmentation of Atypical Antipsychotics in Patients with Schizophrenia-Who Benefits from Blonanserin Augmentation?: An Open-Label, Prospective, Multicenter Study박영민, 박원명, 박주언, 우영섭, 정종현, Do-Hoon Kim, Duk-In Jon, Inki Sohn, Tae Yeon Hwang대한신경정신의학회 · PSYCHIATRY INVESTIGATION2016 · 제13권 제4호Amisulpride를 투여한 급성기 정신분열병 환자에서 주관적 삶의 질소교옥, 이종훈, 최태영대한생물치료정신의학회 · 생물치료정신의학2010 · 제16권 제1호The Tolerability of Mirtazapine Augmentation in Schizophrenic Patients Treated with Risperidone: A Preliminary Randomized Placebo-controlled Trial김보라, 이상혁, 최아영, Jieun Lee, Kang Soo Lee, Keung-Hyang Kim, Keunyoung Yook, Sungjae Lee, Sung Joon Cho, Tae Kyou Choi대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2011 · 제9권 제2호

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