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마이코플라스마 폐렴 소아 환자에서 조기 진단을 위한 항마이코플라스마 항체(IgM)의 의의: 2015년 단일기관연구

Early diagnostic value of the antimycoplasma antibody (IgM) in Mycoplasma pneumoniae pneumonia: A single-center study in 2015

이성규|김민섭|강동희|이광연|안연화|고효정
대한 소아알레르기 호흡기학회 (The Korean Academy Of Pediatric Allergy And Respiratory Disease)|2019.07|Allergy Asthma & Respiratory Disease (알레르기 천식 호흡기질환)|제7권 제3호|pp. 129-136

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참고문헌

키워드

ChildIgMPolymerase chain reactionPneumoniaMycoplasma pneumoniae
주제분류소아과학

초록

Purpose: Recently, the incidence of refractory Mycoplasma pneumoniae (MP) pneumonia has increased in Korea. Given that its early diagnosis is helpful in selection of the treatment, this study aimed at investigating the value of the antimycoplasma antibody (IgM) for early diagnosis of MP pneumonia. Methods: A total of 315 children admitted with MP pneumonia from September 2015 to May 2016 were investigated with the IgM and polymerase chain reaction (PCR) for the diagnosis of MP pneumonia. Specifically, patients were grouped into nonrefractory respiratory MP and refractory MP groups according to their response to macrolide therapy. Results: In the 44 PCR-negative seroconversed children, seroconversed IgM was more frequent in the refractory MP group compared with the nonrefractory respiratory MP group with statistical significance (P<0.001). In the 264 IgM-positive children, the time of antibody reaction was more delayed in the refractory MP group compared to the nonrefractory respiratory MP group with statistical significance (P<0.001). Conclusion: This study showed that there was a higher incidence of seroconversed IgM and delayed antibody reaction in the refractory MP group. In children with suspect MP pneumonia, follow-up studies of antibody are necessary, even through initial antibody and PCR showed negative findings. In addition, this result may suggest that the diagnosis of refractory MP pneunomia will be helpful in establishing the strategy of the treatment.

Abstract

Purpose: Recently, the incidence of refractory Mycoplasma pneumoniae (MP) pneumonia has increased in Korea. Given that its early diagnosis is helpful in selection of the treatment, this study aimed at investigating the value of the antimycoplasma antibody (IgM) for early diagnosis of MP pneumonia. Methods: A total of 315 children admitted with MP pneumonia from September 2015 to May 2016 were investigated with the IgM and polymerase chain reaction (PCR) for the diagnosis of MP pneumonia. Specifically, patients were grouped into nonrefractory respiratory MP and refractory MP groups according to their response to macrolide therapy. Results: In the 44 PCR-negative seroconversed children, seroconversed IgM was more frequent in the refractory MP group compared with the nonrefractory respiratory MP group with statistical significance (P<0.001). In the 264 IgM-positive children, the time of antibody reaction was more delayed in the refractory MP group compared to the nonrefractory respiratory MP group with statistical significance (P<0.001). Conclusion: This study showed that there was a higher incidence of seroconversed IgM and delayed antibody reaction in the refractory MP group. In children with suspect MP pneumonia, follow-up studies of antibody are necessary, even through initial antibody and PCR showed negative findings. In addition, this result may suggest that the diagnosis of refractory MP pneunomia will be helpful in establishing the strategy of the treatment.

참고문헌 (31)

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관련 논문AI추천

Polymerase chain reaction 양성 소아 마이코플라스마 폐렴에서 혈청 IgM enzyme-linked immunosorbent assays의 진단적 가치김경훈, 김진택, 김현희, 김환수, 양은애, 윤종서, 이윤태, 이혜진, 전윤홍대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2018 · 제6권 제5호소아에서 마이코플라즈마 폐렴의 예기적 진단김원덕, 박수진, 이창언영남대학교 의과대학 · Journal of Yeungnam Medical Science2012 · 제29권 제2호Indirect Particle Agglutination Antibody Testing for Early Diagnosis of Mycoplasma pneumoniae pneumonia in Children고정희, 김진수, 오성희대한소아감염학회 · Pediatric Infection and Vaccine2013 · 제20권 제2호Mycoplasma pneumoniae 감염의 진단을 위한 효소 면역 측정 특이 항체 검사의 단기 추적 검사의 유용성강정우, 김병국, 김성원, 서봉옥, 이은영대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2008 · 제18권 제4호증가하는 마크로라이드에 반응하지 않는 마이코플라스마 폐렴의 관련 인자와 임상 양상의 변화김효빈, 박진성, 유인경, 정지현, 탕지륭대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2018 · 제6권 제2호마이코플라즈마 폐렴에서 중합 효소 연쇄반응과 효소면역측정법의 진단적 유용성장욱, 김경원, 김규언, 김은수, 류정우, 박미연, 손명현, 송태원, 신윤호, 이경은, 이병철대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2006 · 제16권 제1호

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