면역글로불린 E 매개 계란 알레르기 환자에 대한 경구 면역치료 3예
Three cases of oral immunotherapy for IgE-mediated egg allergy
0
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Food allergy is an immune-mediated adverse reaction that occurs mainly by food ingestion. Some children with food allergies manifest fatal symptoms like anaphylaxis. Oral immunotherapy (OIT) may offer an effective therapeutic modality for persistent and severe forms of food allergies. We report our experience with OIT in 3 patients with IgE-mediated hen’s egg allergy. Our treatment strategy consists of 1–3 days of initial escalation, 47 to 65 weeks of build-up phase, and 1 year of maintenance phase. Lactobacillus plantarum CJLP133, 1×1010 colony-forming unit/day was taken during OIT. As a result, 1 patient achieved successful desensitization, and 1 patient reached maintenance therapy, but did not obtain desensitization. In addition, 1 patient withdrew from treatment due to anxiety symptoms. Despite the limited number of patients, we experienced and herein presented 3 cases of OIT in egg allergy. More trials of OIT need to be performed as a treatment option in Korean children with food allergies.
Abstract
Food allergy is an immune-mediated adverse reaction that occurs mainly by food ingestion. Some children with food allergies manifest fatal symptoms like anaphylaxis. Oral immunotherapy (OIT) may offer an effective therapeutic modality for persistent and severe forms of food allergies. We report our experience with OIT in 3 patients with IgE-mediated hen’s egg allergy. Our treatment strategy consists of 1–3 days of initial escalation, 47 to 65 weeks of build-up phase, and 1 year of maintenance phase. Lactobacillus plantarum CJLP133, 1×1010 colony-forming unit/day was taken during OIT. As a result, 1 patient achieved successful desensitization, and 1 patient reached maintenance therapy, but did not obtain desensitization. In addition, 1 patient withdrew from treatment due to anxiety symptoms. Despite the limited number of patients, we experienced and herein presented 3 cases of OIT in egg allergy. More trials of OIT need to be performed as a treatment option in Korean children with food allergies.
참고문헌 (20)
- Jones SM, "Food allergy", N Engl J Med, 377, pp.1168~1176 (2017)
- 민택기, "국내 소아 식품알레르기의 역학", Allergy Asthma & Respiratory Disease, 6(1), pp.4~13 (2018), 대한 소아알레르기 호흡기학회[DOI]
- Blom WM, "Accidental food allergy reactions : products and undeclared ingredients", J Allergy Clin Immunol, 142, pp.865~875 (2018)
- Tsuang A, "Childcare and School management issues in food allergy", Curr Allergy Asthma Rep, 16, pp.83~ (2016)
- Pavic I, "Growth of children with food allergy", Horm Res Paediatr, 88, pp.91~100 (2017)
- Yanagida N, "Clinical aspects of oral immunotherapy for the treatment of allergies", Semin Immunol, 30, pp.45~51 (2017)
- 이수영, "즉시형 식품알레르기 치료를 위한 경구면역치료", Allergy Asthma & Respiratory Disease, 2(4), pp.229~235 (2014), 대한 소아알레르기 호흡기학회
- Lee JH, "Increased cow's milk protein-specific IgG4 levels after oral desensitization in 7-to 12-month-old infants", Ann Allergy Asthma Immunol, 111, pp.523~528 (2013)
- Vickery BP, "Individualized IgE-based dosing of egg oral immunotherapy and the development of tolerance", Ann Allergy Asthma Immunol, 105, pp.444~450 (2010)
- Burks AW, "Oral immunotherapy for treatment of egg allergy in children", N Engl J Med, 367, pp.233~243 (2012)
- 박미란, "Prevalence of Immediate-Type Food Allergy in Early Childhood in Seoul", Allergy, Asthma & Immunology Research, 6(2), pp.131~136 (2014), 대한천식알레르기학회
- Freeland DMH, "Oral immunotherapy for food allergy", Semin Immunol, 30, pp.36~44 (2017)
- Carlson G, "Pollen food allergy syndrome(PFAS) : a review of current available literature", Ann Allergy Asthma Immunol, 123, pp.359~365 (2019)
- Tordesillas L, "Skin exposure promotes a Th2-dependent sensitization to peanut allergens", J Clin Invest, 124, pp.4965~4975 (2014)
- Kulis MD, "Immune mechanisms of oral immunotherapy", J Allergy Clin Immunol, 141, pp.491~498 (2018)
- 신미용, "계란 알레르기의 최신 지견", Allergy Asthma & Respiratory Disease, 3(1), pp.15~21 (2015), 대한 소아알레르기 호흡기학회
- Escudero C, "Early sustained unresponsiveness after short-course egg oral immunotherapy : a randomized controlled study in egg-allergic children", Clin Exp Allergy, 45, pp.1833~1843 (2015)
- Epstein-Rigbi N, "Quality of life of food-allergic patients before, during, and after oral immunotherapy", J Allergy Clin Immunol Pract, 7, pp.429~436.e2 (2019)
- Pajno GB, "EAACI Guidelines on allergen immunotherapy : IgE-mediated food allergy", Allergy, 73, pp.799~815 (2018)
- Boyano-Martinez T, "Prediction of tolerance on the basis of quantification of egg white-specific IgE antibodies in children with egg allergy", J Allergy Clin Immunol, 110, pp.304~309 (2002)