Syndecan-4 cytoplasmic domain could disturb the multilamellar vesicle
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초록
Syndecan-4 cytoplasmic domain was tested to confirm the interactions with the bilayer membrane using 31P solid-state NMR measurements. Syndecan-4 was known as a coreceptor with integrins in the cell adhesion. The syndecan-4 V region is not understood of its functional roles and tested its ability of the interaction with multilamellar vesicles. The 31P powder pattern was dramatically changed and showed isotropic peak which imply the bilayer membrane changed its topology to the micelle-like structure. Especially, phosphatidylcholine membrane was affected this effect more than phosphatidylethanolamine membrane. Keywords: solid-state NMR, powder pattern, membrane topology, protein-membrane interactions, Syndecan, signal transduction
Abstract
Syndecan-4 cytoplasmic domain was tested to confirm the interactions with the bilayer membrane using 31P solid-state NMR measurements. Syndecan-4 was known as a coreceptor with integrins in the cell adhesion. The syndecan-4 V region is not understood of its functional roles and tested its ability of the interaction with multilamellar vesicles. The 31P powder pattern was dramatically changed and showed isotropic peak which imply the bilayer membrane changed its topology to the micelle-like structure. Especially, phosphatidylcholine membrane was affected this effect more than phosphatidylethanolamine membrane. Keywords: solid-state NMR, powder pattern, membrane topology, protein-membrane interactions, Syndecan, signal transduction
참고문헌 (13)
- M. Bernfield, , Annu. Rev. Biochem, 68, pp.729~777 (1999)
- M. D. Bass, , Biochem. J., 368, pp.1~15 (2002)
- S. Miyamoto, , J. Cell. Biol., 131, pp.791~805 (1995)
- E. A. Clark, , Science, 268, pp.233~239 (1995)
- M. R. Morgan, , Nat. Rev. Mol. Cell. Biol, 8, pp.957~969 (2007)
- D. Lee, , J. Biol. Chem., 273, pp.13022~13029 (1998)
- B. K. Koo, , J. Mol. Biol., 355, pp.651~663 (2006)
- K. Matsuzaki, , Biochim. Biophys. Acta., 1462, pp.1~10 (1999)
- Oc Hee Han, "Possible Misinterpretation in Surface Adsorption Studies by CP-MAS NMR", Journal of the Korean Magnetic Resonance Society, 12(1), pp.60~64 (2008), 한국자기공명학회
- N. Fa, , Chem. Phys. Lipids, 144, pp.108~116 (2006)
- R. B. Merrifield, , J. Am. Chem. Soc, 85, pp.2149~2154 (1963)
- Siwon Kim, "Interactions of membrane and PMAP-23 studied by 31P solid-sate NMR spectroscopy", Journal of the Korean Magnetic Resonance Society, 11(2), pp.110~114 (2007), 한국자기공명학회
- 박태준, "Structural Studies of Hydrotalcite Compounds Calcined withDifferent Temperatures by 27Al Solid-state NMR Spectroscopy", Journal of the Korean Magnetic Resonance Society, 11(1), pp.42~47 (2007), 한국자기공명학회